Category: 112-63-0

Fernandes, Keysson V.; Cavalcanti, Elisa D. C.; Cipolatti, Eliane P.; Aguieiras, Erika C. G.; Pinto, Martina C. C.; Tavares, Fernanda A.; da Silva, Priscila R.; Fernandez-Lafuente, Roberto; Arana-Pena, Sara; Pinto, Jose Carlos; Assuncao, Charles L. B.; da Silva, Jose Andre C.; Freire, Denise M. G. published the artcile< Enzymatic synthesis of biolubricants from by-product of soybean oil processing catalyzed by different biocatalysts of Candida rugosa lipase>, COA of Formula: C19H34O2, the main research area is lipase synthesis biolubricant soybean oil distillate.

The present work studied the synthesis of biolubricants from byproducts of soybean oil processing using the lipase from Candida rugosa (CRL) both in free and immobilized forms, as biocatalysts. Soybean fatty acid distillate (SFAD) was used for first time as source of free fatty acids (FFA) to produce biolubricants via their enzymic esterification with neopentyl glycol (NPG) and trimethylolpropane (TMP) alcs. in a solvent-free medium. The immobilization of CRL was performed via interfacial activation using a com. hydrophobic support (Accurel) and a home-made core-shell matrix of poly(Me methacrylate) (PMMA). Conversions of about 80% were obtained using lyophilized CRL after 30 or 180 min using NPG and TMP, resp. When CRL-PMMA/PMMA was used to catalyze the synthesis of NPG esters, 90% conversion was achieved after only 6 h, while CRL-Accurel were more active using TMP. The biocatalysts maintained the reaction conversion during eight batches of 24 h. The lubricant properties of the products were also characterized, showing that it can be an environmentally friendly alternative for petrol lubricants.

Catalysis Today published new progress about Enzymic esterification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Pengyun; Ma, Songqi; Wang, Binbo; Xu, Xiwei; Feng, Hongzhi; Yu, Zhen; Yu, Tao; Liu, Yanlin; Zhu, Jin published the artcile< Degradable benzyl cyclic acetal epoxy monomers with low viscosity: Synthesis, structure-property relationships, application in recyclable carbon fiber composite>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is benzyl cyclic acetal epoxy carbon fiber composite degradable thermoset; thermal optical mech property vacuum assisted resin transfer molding.

Degradable thermosets can address the recycle issue of conventional thermosets and downstream materials like carbon fiber composites. Significant advances have been achieved on their recyclability even on high performance, but their processability was neglected. Herein, for the first time, from the processing point of view, degradable epoxy monomers with low viscosity were designed. Et or Me group was incorporated into the benzyl cyclic acetal structure to obtain three acetal epoxy monomers by the acetalization between p-hydroxybenzaldehyde analogs and triols to achieve diols, followed by reacting with epichlorohydrin. Two benzyl cyclic acetal epoxy monomers with Et group are liquid The viscosity and structure-property relationship of epoxy monomers were systematically investigated from experiments to simulate computation. The cured epoxies possessed favorable thermal properties, mech. properties and controllable degradability. Furthermore, the epoxy monomer with suitable viscosity was used to prepare carbon fiber composites with excellent performance via vacuum assisted resin transfer molding (VARTM) process. Meanwhile, the non-destructive recovery of carbon fiber was realized by taking advantage of the degradability of the acetal epoxy matrix.

Composites Science and Technology published new progress about Biodegradability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koukaki, Marina; Vlanti, Anna; Goudela, Sophia; Pantazopoulou, Areti; Gioule, Harris; Tournaviti, Stella; Diallinas, George published the artcile< The Nucleobase-ascorbate Transporter (NAT) Signature Motif in UapA Defines the Function of the Purine Translocation Pathway>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nucleobase ascorbate transporter NAT motif UapA purine translocation Aspergillus; Aspergillus gene uapA urate xanthine transporter sequence.

UapA, a member of the NAT/NCS2 family, is a high affinity, high capacity, uric acid-xanthine/H+ symporter of Aspergillus nidulans. We have previously presented evidence showing that a highly conserved signature motif ([Q/E/P]408-N-X-G-X-X-X-X-T-[R/K/G])417 is involved in UapA function. Here, we present a systematic mutational anal. of conserved residues in or close to the signature motif of UapA. We show that even the most conservative substitutions of residues Q408, N409 and G411 modify the kinetics and specificity of UapA, without affecting targeting in the plasma membrane. Q408 substitutions show that this residue determines both substrate binding and transport catalysis, possibly via interactions with position N9 of the imidazole ring of purines. Residue N409 is an irreplaceable residue necessary for transport catalysis, but is not involved in substrate binding. Residue G411 determines, indirectly, both the kinetics (Km, V) and specificity of UapA, probably due to its particular property to confer local flexibility in the binding site of UapA. In silico predictions and a search in structural databases strongly suggest that the first part of the NAT signature motif of UapA (Q408NNG411) should form a loop, the structure of which is mostly affected by mutations in G411. Finally, substitutions of residues T416 and R417, despite being much better tolerated, can also affect the kinetics or the specificity of UapA. Our results show that the NAT signature motif defines the function of the UapA purine translocation pathway and strongly suggest that this might occur by determining the interactions of UapA with the imidazole part of purines.

Journal of Molecular Biology published new progress about Aspergillus nidulans. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fu, Fang; Lu, Wei; Zheng, Yue; Chen, Kai; Sun, Chen; Cong, Lina; Liu, Yulong; Xie, Haiming; Sun, Liqun published the artcile< Regulating lithium deposition via bifunctional regular-random cross-linking network solid polymer electrolyte for Li metal batteries>, Reference of 112-63-0, the main research area is cross linking network solid polymer lithium metal battery electrolyte.

The low coulombic efficiency and poor cycle performance deriving from uncontrolled growth of dendrites have caused a serious obstacle to the practical application of lithium metal. Herein we propose a bifunctional regular-random dual crosslinking network solid polymer electrolyte (RRa-SPE) for dendrite-free all-solid-state lithium metal batteries. Under the synergistic effect of regular polymerization skeleton and random crosslinking network, the RRa-SPE effectively regulates the lithium deposition and facilitates the generation of a highly homogeneous and robust solid-electrolyte interphase (SEI) layer on lithium metal. Besides, this RRa-SPE shows benign ionic conductivity of 4.36 x 10-4 S cm-1 (at 30°C), high lithium ion transference number of 0.76 and enhanced mech. strength. The Li/RRa-SPE/Li sym. cell maintains low and stable voltage polarization (0.15 V) after circulating for 1200 h at 0.5 mA cm-2. Improved LiFePO4/RRa-SPE/Li cell exhibits excellent rate capability and prominent cycle performance with a capacity retention of 99.6% after 240 cycles at 0.5 C at 30°C.

Journal of Power Sources published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Yue; Li, Kun; Gao, Wei; Liu, Xiaoyu; Yuan, Haolin; Tang, Liangfu; Fan, Zhijin published the artcile< Tandem Synthesis of 1,2,3-Thiadiazoles with 3,4-Dichloroisothiazoles and Hydrazines under External Oxidant- and Sulfur-free Conditions>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is thiadiazole preparation; dichloroisothiazole ketone hydrazine tandem nucleophilic addition intramol rearrangement.

1,2,3-Thiadiazoles are among the most important heterocyclic motifs with wide applications in natural products and medicinal chem. Herein, authors disclosed a tandem reaction for the synthesis of structurally diverse 1,2,3-thiadiazoles from 3,4-dichloroisothiazol-5-ketones and hydrazines. This method is characterized by free of external oxidants or sulfur requirements, mild reaction conditions, broad substrate scope and easy purification

Organic Letters published new progress about Hydrazines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lei, Tao; Wei, Si-Meng; Feng, Ke; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu published the artcile< Borylation of Diazonium Salts by Highly Emissive and Crystalline Carbon Dots in Water>, Quality Control of 112-63-0, the main research area is diazonium salt borylation crystalline carbon dot water green catalyst; boronic ester preparation photocatalyst mechanism; borylation; carbon dots; emission; photochemistry; photoredox chemistry.

Efficient borylation reaction of diazonium salts in water is realized for the first time by using easily prepared, highly emissive and crystalline carbon dots. Electron-donating and electron-withdrawing groups on diazonium salts were well tolerated with moderate to good conversion efficiency. Compared with widely used metal complexes, organic dyes and quantum dots, the approach presented herein uses carbon dots, which are nontoxic and possess good biol. and medicinal compatibility and high reactivity. Therefore, this approach presents a new prospective use for carbon dots in green chem.

ChemSusChem published new progress about Absorption spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Morgan, H.; Taylor, D. M.; D’Silva, C. published the artcile< Surface plasmon resonance studies of chemisorbed biotin-streptavidin multilayers>, Formula: C19H34O2, the main research area is surface plasmon resonance spectroscopy protein; immobilization biotin bisbiotin streptavidin gold.

Surface plasmon resonance spectroscopy has been used to confirm that a monolayer of biotin may be immobilized by chemisorption onto evaporated gold films and subsequently used to bind a monolayer of streptavidin. As expected, the strong affinity of the protein for the biotin ligand ensures that the binding of the protein layer is highly specific. No non-specific binding occurs to the biotinylated gold surface: the protein layer is resistant to washing in 1M NaCl. It is suggested that multilayer structures may be assembled by chemisorption of successive protein monolayers using a bifunctional bisbiotin ligand for connecting individual layers.

Thin Solid Films published new progress about Chemisorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hapuarachchige, Sudath; Montano, Gilbert; Ramesh, Chinnasamy; Rodriguez, Delany; Henson, Lauren H.; Williams, Casey C.; Kadavakkollu, Samuel; Johnson, Dennis L.; Shuster, Charles B.; Arterburn, Jeffrey B. published the artcile< Design and Synthesis of a New Class of Membrane-Permeable Triazaborolopyridinium Fluorescent Probes>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is synthesis membrane permeable triazaborolopyridinium fluorescent probe.

A new class of fluorescent triazaborolopyridinium compounds was synthesized from hydrazones of 2-hydrazinylpyridine (HPY) and evaluated as potential dyes for live-cell imaging applications. The HPY dyes are small, their absorption/emission properties are tunable through variation of pyridyl or hydrazone substituents, and they offer favorable photophys. characteristics featuring large Stokes shifts and general insensitivity to solvent or pH. The stability, neutral charge, cell membrane permeability, and favorable relative influences on the water solubility of HPY conjugates are complementary to existing fluorescent dyes and offer advantages for the development of receptor-targeted small-mol. probes. This potential was assessed through the development of a new class of cysteine-derived HPY-conjugate imaging agents for the kinesin spindle protein (KSP) that is expressed in the cytoplasm during mitosis and is a promising chemotherapeutic target. Conjugates possessing the neutral HPY or charged Alexa Fluor dyes that function as potent, selective allosteric inhibitors of the KSP motor were compared using biochem. and cell-based phenotypic assays and live-cell imaging. These results demonstrate the effectiveness of the HPY dye moiety as a component of probes for an intracellular protein target and highlight the importance of dye structure in determining the pathway of cell entry and the overall performance of small-mol. conjugates as imaging agents.

Journal of the American Chemical Society published new progress about Allosterism. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sake, Cara L.; Metcalf, Alexander J.; Meagher, Michelle; Di Paola, Jorge; Neeves, Keith B.; Boyle, Nanette R. published the artcile< Isotopically nonstationary 13C metabolic flux analysis in resting and activated human platelets>, Related Products of 112-63-0, the main research area is isotopically nonstationary metabolic flux platelet thrombin; Blood platelets; Metabolic flux analysis; Metabolomics; Thrombin.

Platelet metabolism is linked to platelet hyper- and hypoactivity in numerous human diseases. Developing a detailed understanding of the link between metabolic shifts and platelet activation state is integral to improving human health. Here, we show the first application of isotopically nonstationary 13C metabolic flux anal. to quant. measure carbon fluxes in both resting and thrombin activated platelets. Metabolic flux anal. results show that resting platelets primarily metabolize glucose to lactate via glycolysis, while acetate is oxidized to fuel the tricarboxylic acid cycle. Upon activation with thrombin, a potent platelet agonist, platelets increase their uptake of glucose 3-fold. This results in an absolute increase in flux throughout central metabolism, but when compared to resting platelets they redistribute carbon dramatically. Activated platelets decrease relative flux to the oxidative pentose phosphate pathway and TCA cycle from glucose and increase relative flux to lactate. These results provide the first report of reaction-level carbon fluxes in platelets and allow us to distinguish metabolic fluxes with much higher resolution than previous studies.

Metabolic Engineering published new progress about Analysis (isotopically nonstationary 13C metabolic flux). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Spicer, Julie A.; Miller, Christian K.; O’Connor, Patrick D.; Jose, Jiney; Huttunen, Kristiina M.; Jaiswal, Jagdish K.; Denny, William A.; Akhlaghi, Hedieh; Browne, Kylie A.; Trapani, Joseph A. published the artcile< Substituted arylsulphonamides as inhibitors of perforin-mediated lysis>, Quality Control of 112-63-0, the main research area is arylsulfonamide perforin mediated lysis inhibitor structure activity Immunosuppressive; Arylsulphonamide; Bioisostere; Immunosuppressant; Perforin; Perforin inhibitor.

The structure-activity relationships for a series of arylsulfonamide-based inhibitors of the pore-forming protein perforin have been explored. Perforin is a key component of the human immune response, however, inappropriate activity has also been implicated in certain auto-immune and therapy-induced conditions such as allograft rejection and graft vs. host disease. Since perforin is expressed exclusively by cells of the immune system, inhibition of this protein would be a highly selective strategy for the immunosuppressive treatment of these disorders. Compounds from this series were demonstrated to be potent inhibitors of the lytic action of both isolated recombinant perforin and perforin secreted by natural killer cells in vitro. Several potent and soluble examples were assessed for in vivo pharmacokinetic properties and found to be suitable for progression to an in vivo model of transplant rejection.

European Journal of Medicinal Chemistry published new progress about Arenesulfonamides Role: PAC (Pharmacological Activity), PKT (Pharmacokinetics), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics