Category: 112-63-0

Huenerhoff, Ernst published the artcile< Pyridinium perbromide, a mild brominating agent for carbon-carbon double bonds>, Computed Properties of 112-63-0, the main research area is bromination olefin pyridinium perbromide.

Compounds containing double bonds, i.e. cyclohexene, styrene, and vitamin C, were treated with pyridinium perbromide (I), prepared from pyridine reaction with HBr and Br to give the corresponding Br addition compounds

Praxis der Naturwissenschaften, Chemie published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Yan-Hua; Li, Wei; Liu, Dan-Dan; Bai, Meng-Xuan; Song, Hong-Rui; Xu, Yong-Nan; Lee, SangKook; Zhou, Zhi-Peng; Wang, Jian; Ding, Huai-Wei published the artcile< Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3Kα inhibitors>, Quality Control of 112-63-0, the main research area is imidazo pyridine quinazolinone preparation PI3K alpha inhibitor anticancer agent; Anticancer agents; Imidazo[1,2-a]pyridine; PIK3CA gene; Phosphatidylinositol 3-kinase; Quinazolin-4(3H)-one.

Phosphatidylinositol 3-kinase (PI3K) is a pivotal regulator of intracellular signaling pathways and considered as a promising target in the development of a therapeutic treatment of cancer. Among the different PI3K subtypes, the PIK3CA gene encoding PI3K p110α is frequently mutated and overexpressed in majority of human cancers. Therefore, the inhibition of PI3Kα has been considered to be an efficient approach for the treatment of cancer. In this study, two series compounds containing hydrophilic group in imidazo[1,2-a]pyridine and quinazolin-4(3H)-one were synthesized and their antiproliferative activities against five cancer cell lines, including HCT-116, SK-HEP-1, MDA-MB-231, SNU638 and A549, were evaluated. Compound I with most potent antiproliferative activity was selected for further biol. evaluation. PI3K kinase assay showed that I has selectivity for PI3Kα distinguished from other isoforms. The western blot assay indicated that I is more effective than HS-173, an imidazopyridine-based PI3Ka inhibitor, in reducing the levels of phospho-Akt. All these results suggested that I is a potent PI3Kα inhibitor and could be considered as a potential candidate for the development of anticancer agents.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alvarez-Lorenzo, Carmen; Hiratani, Haruyuki; Tanaka, Kazunori; Stancil, Kimani; Grosberg, Alexander Yu.; Tanaka, Toyoichi published the artcile< Simultaneous Multiple-Point Adsorption of Aluminum Ions and Charged Molecules by a Polyampholyte Thermosensitive Gel: Controlling Frustrations in a Heteropolymer Gel>, Formula: C19H34O2, the main research area is multiple point adsorption polyampholyte hydrogel swelling; aluminum ion adsorption polyampholyte gel.

Data on concurrent multiple point adsorption of two oppositely charged species of “”target mols.”” (aluminum ions and 1,3,6,8-pyrenetetrasulfonic sodium salt (Py-4)) by a polyampholyte gel of N-isopropylacrylamide (NIPA, 6 M) with methacrylic acid (MAA, 80 mM) and methacrylamidopropyl trimethylammonium chloride (MAPTAC, 80 mM) is reported. The goal of this study is to test the mutual frustrations created by adsorption of one species on the adsorption of the other. Understanding these frustrations is an important step toward elucidating the memory of conformations in heteropolymer systems. It was found that in the absence of aluminum, the adsorption of Py-4 was suppressed by gel collapse, presumably because of an increase in MAA/MAPTAC ionic pairs that prevents the formation of potential adsorbing centers. Adding a moderate amount of aluminum significantly enhances adsorption of Py-4 by the collapsed gel, indicating that aluminum ions compete for bonds with MAA and help release vacant MAPTAC centers. Finally, with further increase of aluminum, the Py-4 multiple point adsorption is again suppressed, pointing out the frustrations created by aluminum-mediated effective cross-links. The cooperativity of the adsorption process is also analyzed.

Langmuir published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Williams, Davdi R.; Li, Jie published the artcile< Total synthesis of myxovirescin A1>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is myxovirescin A1 total synthesis.

Stereocontrolled synthesis of myxovirescin A1, a 28-membered macrolactam lactone, is accomplished via a highly convergent route. Ring closure to the macrocycle is realized by macro-lactamization of azido acid I using the Mukaiyama procedure.

Tetrahedron Letters published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kuo, W. N.; Ganesan, U.; Robinson, A.; Flanders, J. published the artcile< Modulation of bacterial protease by peptides, phospholipids, and nucleotides>, COA of Formula: C19H34O2, the main research area is proteinase modulation peptide phospholipid nucleotide bacteria.

Various agents are tested for their effects on bacterial protease (type IX). The activity was measured by the production of folin-pos. amino acids and peptides from proteolysis. Phosphatidylethanolamine, aprotinin, and tRNA effectively stimulated the protease, whereas λ phage DNA (HindIII digest), dGTP, dCTP, GTP, TTP, dTTP, and plasmid PS62-PL DNA significantly inhibited the protease. In addition, L-α-phosphatidic acid, L-α-phosphatidylglycerol (dioleoyl), pepstatin A, palmitic acid, cardiolipin, phosphatidylserine, and MS2 RNA exerted moderate inhibition. Similar regulation of proteolysis was also confirmed by the anal. of peptide bands in SDS-PAGE.

Biochemical Archives published new progress about Bacteria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Juyeon; Byun, Jaewon; Han, Jeehoon published the artcile< Process integration and economics of gamma-valerolactone using a cellulose-derived ethyl levulinate intermediate and ethanol solvent>, Category: esters-buliding-blocks, the main research area is ethyl levulinate gamma valerolactone preparation.

This study combines two catalytic conversion strategies, cellulose to Et levulinate and subsequently to gamma-valerolactone, into an integrated process. The effect of integrating the cellulose-to-Et levulinate and Et levulinate-to-gamma-valerolactone processes on a com. scale is investigated to improve energy efficiency and economics by performing a process simulation study. The conversion strategies show a low energy efficiency of 6.8% using excess ethanol solvent to achieve high yields of Et levulinate and gamma-valerolactone; however, in the integrated process, 0.4% of the ethanol and 30.8% of the cellulose-to-Et levulinate heat requirements are supplied by the Et levulinate-to-gamma-valerolactone process. The min. selling price for the integrated process is estimated to be $5.63/kg gamma-valerolactone, which makes it an economically feasible option for gamma-valerolactone production Finally, we conducted a sensitivity anal. of key parameters (cellulose price, steam price, and ethanol price) highly depending on the min. selling price of gamma-valerolactone.

Energy (Oxford, United Kingdom) published new progress about Heat exchangers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Banaras, Saira; Javaid, Arshad; Khan, Iqra Haider published the artcile< Bioassays guided fractionation of Ageratum conyzoides extract for the identification of natural antifungal compounds against Macrophomina phaseolina>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is octadecanal heptadecanol chloroform extract Ageratum antifungal agent Macrophomina.

Macrophomina phaseolina (Tassi) Goid. is a soil-borne fungal pathogen causing diseases in more than 500 plant species. The present study aimed to identify possible antifungal constituents in different parts of billygoat-weed (Ageratum conyzoides L.) through bioassays guided fractionation for the control of M. phaseolina. Extracts of different parts of the weed were made in methanol and antifungal bioassays were conducted using 1, 2, 3, 4 and 5% concentrations of the extract Stem extract caused the highest inhibition in fungal biomass (20-83%) followed by leaf extract (16-67%). Methanolic stem extract was partitioned using four organic solvents namely n-hexane, chloroform, Et acetate and n-butanol. Bioassays carried out with different concentrations (3.125, 6.25, 12.5, 25, 50, 100 and 200 mg mL-1) of the sub-fractions of stem extract revealed the highest antifungal potential of chloroform sub-fraction with 56-93% reduction in the fungal biomass followed by n-butanol, Et acetate and n-hexane sub-fractions causing 24-76%, 7-75% and 5-70% reduction in fungal biomass over control, resp. Chloroform sub-fraction with the highest antifungal potential was analyzed by GC-MS. Out of 10 compounds identified in this sub-fraction, 2H-1-benzopyran, 7-dimethoxy-2,2-dimethyl- (27.58%) was the most abundant followed by hexadecanoic acid, Me ester (18.85%); 11-octadecenoic acid, Me ester (15.28%) and 1,2-benzenedicarboxylic acid, mono(2-ethylhexyl) ester (10.88%), which could be responsible for antifungal activity.

International Journal of Agriculture and Biology published new progress about Ageratum conyzoides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Jinsong; Chen, Ying; Yang, Chao; Liu, Ting; Wang, Mingping; Xu, Haojie; Zhang, Ling; Zheng, Canhui; Song, Yunlong; Zhu, Ju published the artcile< Structure-based optimization leads to the discovery of NSC765844, a highly potent, less toxic and orally efficacious dual PI3K/mTOR inhibitor>, SDS of cas: 112-63-0, the main research area is dual PI3K mTOR inhibitor preparation cancer NSC 765844; Anticancer; Dual inhibitors; Mammalian target of rapamycin (mTOR); Phosphoinositide 3-kinase (PI3K).

The phosphoinositide 3-kinase (PI3K) family is one of the most frequently activated enzymes in a wide range of human cancers; thus, inhibition of PI3K represents a promising strategy for cancer therapy. Herein, a series of benzylamine substituted arylsulfonamides were designed and synthesized as dual PI3K/mTOR inhibitors using a strategy integrating focused library design and virtual screening, resulting in the discovery of 13b (NSC765844). The compound 13b exhibits highly potent enzyme inhibition with IC50s of 1.3, 1.8, 1.5, 3.8 and 3.8 nM for PI3Kα, β, γ, δ, and mTOR, resp. 13b was further evaluated in NCI by an in vitro cytotoxic screening program. Broad-spectrum antitumor activities with mean GI50 value of 18.6 nM against approx. 60 human tumor cell lines were found. 13b displayed favorable physicochem. properties and superior pharmacokinetic profiles for animal studies. It significantly inhibited tumor growth when administered orally in an A549 non-small-cell lung carcinoma xenograft and BEL7404 human hepatocellular carcinoma xenograft models. On the basis of its excellent in vivo efficacy and superior pharmacokinetic profiles, 13b has been selected for further preclin. investigation as a promising anticancer drug candidate.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Hui-Li; Xie, Ming-Sheng; Qu, Gui-Rong; Guo, Hai-Ming published the artcile< Organocatalytic Enantioselective Allylic Etherification of Morita-Baylis-Hillman Carbonates and Silanols>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is organocatalytic enantioselective allylic etherification MBH carbonate silanol; siloxy alkenylcarbonate preparation; crystal structure siloxyalkenylcarbonate; mol structure siloxyalkenylcarbonate.

The organocatalytic asym. allylic etherification reaction of Morita-Baylis-Hillman carbonates and silanols is reported for the 1st time. With modified cinchona alkaloid (DHQD)2PYR as the catalyst, aromatic, heterocyclic, or aliphatic Morita-Baylis-Hillman carbonates (25 examples) worked well with triphenylsilanol, affording the corresponding products in moderate to good yields (up to 98%), high regioselectivities (>20:1), and good enantioselectivities (up to 92%). When dimethylphenylsilanol was used as the nucleophile, the product was obtained in 60% yield and 87% ee.

Journal of Organic Chemistry published new progress about Carbonates Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Rui; Wang, Sihui; Liu, Qing; Xie, Kaili; Xu, Yongsong; Shi, Jinli; Wang, Zhimin; Gong, Muxin published the artcile< Liquiritin enhancing intestinal absorption of paeoniflorin in in situ single-pass intestinal perfusion and in vitro Caco-2 cell monolayer absorption models>, Application In Synthesis of 112-63-0, the main research area is colorectal adenocarcinoma paeoniflorin liquiritin intestinal absorption pharmacokinetics.

In this study, we aimed to determine the interaction of paeoniflorin and liquiritin during intestinal absorption. Interaction between paeoniflorin and liquiritin (100 μM) was studied using in situ single-pass intestinal perfusion (SPIP) model use the whole small intestine and in vitro Caco-2 cell monolayer bidirectional transport model. In situ SPIP research demonstrated that liquiritin significantly increased the Ka, Papp, absorption rate, and cumulative amount of paeoniflorin up to 7.97, 8.98, 7.07, and 10.71 folds, resp., even higher than that of verapamil, a specific P-gp inhibitor, and control. Furthermore, 18 β-glycyrrhetinic acid (18 β-GA) markedly increased the Ka, Papp, absorption rate, and cumulative amount of paeoniflorin up to 3.30, 3.27, 3.42, and 4.04 folds, resp. Bidirectional transport studies indicated that liquiritin and paeoniflorin could prompt the absorption of each other by increasing the Papp (AP-BL) of paeoniflorin and liquiritin from (3.83 ± 0.51) x 10-7 to (5.60 ± 0.51) x 10-7 cm/s and (3.86 ± 0.34) x 10-7 to (8.26 ± 0.51) x 10-7 cm/s, resp. The 18 β-GA significantly prompted the Papp (AP-BL) of paeoniflorin to (5.54 ± 0.92) x 10-7 cm/s. Liquiritin and paeoniflorin increased the absorption of each other. This could provide essential reference to predict the oral bioavailability, the pharmacokinetics, and the clin. application of coadministration of liquiritin-and paeoniflorin-containing SGT and other herbal formulas.

Pharmacognosy Magazine published new progress about Colorectal adenocarcinoma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics