Category: 112-63-0

Wang, Rubing; Chen, Chengsheng; Zhang, Xiaojie; Zhang, Changde; Zhong, Qiu; Chen, Guanglin; Zhang, Qiang; Zheng, Shilong; Wang, Guangdi; Chen, Qiao-Hong published the artcile< Structure-Activity Relationship and Pharmacokinetic Studies of 1,5-Diheteroarylpenta-1,4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents>, HPLC of Formula: 112-63-0, the main research area is pentadienone curcumin structure pharmacokinetics antitumor neoplasm.

Forty-three 1,5-diheteroaryl-1,4-pentadien-3-ones were designed as potential curcumin mimics, structurally featuring a central five-carbon dienone linker and two identical nitrogen-containing aromatic rings. They were synthesized using a Horner-Wadsworth-Emmons reaction as the critical step and evaluated for their cytotoxicity and antiproliferative activities toward both androgen-insensitive and androgen-sensitive prostate cancer cell lines and an aggressive cervical cancer cell line. Most of the synthesized compounds showed distinctly better in vitro potency than curcumin in the four cancer cell lines. The structure-activity data acquired from the study validated (1E,4E)-1,5-diheteroaryl-1,4-pentadien-3-ones as an excellent scaffold for in-depth development for clin. treatment of prostate and cervical cancers. 1-Alkyl-1H-imidazol-2-yl, ortho pyridyl, 1-alkyl-1H-benzo[d]imidazole-2-yl, 4-bromo-1-methyl-1H-pyrazol-3-yl, thiazol-2-yl, and 2-methyl-4-(trifluoromethyl)thiazol-5-yl were identified as optimal heteroaromatic rings for the promising in vitro potency. (1E,4E)-1,5-Bis(2-methyl-4-(trifluoromethyl)thiazol-5-yl)penta-1,4-dien-3-one, featuring thiazole rings and trifluoromethyl groups, was established as the optimal lead compound because of its good in vitro potency and attractive in vivo pharmacokinetic profiles.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Srivastava, Neha; Alhazmi, Alaa; Mohammad, Akbar; Haque, Shafiul; Srivastava, Manish; Pal, Dan Bahadur; Singh, Rajeev; Mishra, P. K.; Vo, Dai Viet N.; Yoon, Taeho; Gupta, Vijai Kumar published the artcile< Biohydrogen production via integrated sequential fermentation using magnetite nanoparticles treated crude enzyme to hydrolyze sugarcane bagasse>, Application In Synthesis of 112-63-0, the main research area is biohydrogen integrated sequential fermentation magnetite nanoparticle sugarcane bagasse.

This study presents a potential approach to enhance integrated sequential biohydrogen production from waste biomass using magnetite nanoparticle (Fe3O4 NPs) which is synthesized through waste seeds of Syzygium cumini. Consequences of 0.5% Fe3O4 NPs have been investigated on the thermal and pH stability of fungal crude cellulase. It is noticed that Fe3O4 NPs treated enzyme and control exhibits 100% activity in the temperature range of 45-60鎺矯 and 45-55鎺矯, resp. Moreover, Fe3O4 NPs treated enzyme showed extended thermal stability in the temperature range of 50-60鎺矯 up to 12 h. Beside this, Fe3O4 NPs treated enzyme possesses 100% stability in the pH range of 5.0-7.0 whereas control exhibited only at pH 6.0. Enzymic hydrolysis via Fe3O4 NPs treated enzyme has been employed which produces é–?8.0 g/L reducing sugars from sugarcane bagasse. Subsequently, sugar hydrolyzate has been utilized as substrate in the sequential integrated fermentation that produces é–?427.0 mL/L cumulative hydrogen after 408 h. This approach may have potential for the pilot scale production of biohydrogen from waste biomass at low-cost in an eco-friendly manner.

International Journal of Hydrogen Energy published new progress about Bagasse. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Su, Boqing; Tian, Jingyuan; Liu, Mengshi; Wang, Kanghui; Yang, Wanling; Ning, Jinrong; Li, Yongmei; Zheng, Guodong published the artcile< Analysis of the chemical components of pomelo peels (Citrus grandis [L.] Osbeck) from different cultivars by using supercritical CO2 fluid extraction and ultra-high-performance liquid chromatography-tandem mass spectrometry>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Citrus pomelo peel chem supercritical extraction UPLC MS; UHPLC-MS/MS; cultivar; pomelo peel; supercritical fluid extraction.

Five pomelo cultivars (i.e., Citrus grandis cv. Shatianyou, Citrus grandis cv. Guanximiyou, Citrus grandis cv. Yuhuanyou, Citrus grandis cv. Duweiwendanyou and Citrus grandis cv. Liangpingyou) from different origins in China were selected to analyze their components by using supercritical CO2 fluid extraction coupled with ultra-high-performance liquid chromatog.-tandem mass spectrometry. A total of 45 compounds were identified in the supercritical CO2 fluid extracts of the pomelo peels from the five cultivars. These compounds included eight flavonoids, 18 coumarins, four organic acids, three aldehydes, and 12 other compounds, which were identified using the obtained MS data and by comparison with com. standards, orbitrap Chinese Traditional Medicine Library, and previous literature. Twenty-five of the identified compounds were detected for the first time in the pomelo peel extracts Results suggested that the pomelo peels of C. grandis cv. Shatianyou contained the most natural chem. compositions The pooled result may offer scientific evidence for further development and utilization of pomelo peels and a route for screening appropriate varieties for various demands.

Journal of Separation Science published new progress about Citrus grandis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mohd. Hussin, Fathin Najihah Nor; Attan, Nursyafreena; Abdul Wahab, Roswanira published the artcile< Taguchi design-assisted immobilization of Candida rugosa lipase onto a ternary alginate/nanocellulose/montmorillonite composite: Physicochemical characterization, thermal stability and reusability studies>, Formula: C19H34O2, the main research area is Candida rugosa lipase immobilization nanocellulose; Alginate; Candida rugosa lipase; Enzyme immobilization; Montmorillonite; Nanocellulose; Taguchi optimization.

Biomass from oil palm frond leaves (OPFL) is an excellent reservoir of lignocellulosic material which full potential remains untapped. This study aimed to statistically optimize the covalent immobilization of Candida rugosa lipase (CRL) onto a ternary support comprised of OPFL derived nanocellulose (NC) and montmorillonite (MMT) in alginate (ALG) (CRL-ALG/NC/MMT). The coarser topol. and the presence of characteristic spherical globules in the field emission scanning electron micrographs and at. force micrographs, resp., supported the existence of CRL on ALG/NC/MMT. In addition, amide peaks at 3478 and 1640 cm-1 in the fourier transform IR spectra affirmed that CRL was covalently bonded to ALG/NC/MMT. The optimized Taguchi Design-assisted immobilization of CRL onto ALG/NC/MMT (7 h of immobilization, 35鎺矯, pH 5, 7 mg/mL protein loading) gave a production yield of 92.89% of Et levulinate (EL), as proven by gas chromatog.-mass spectrometric ([M] +m/z 144, C7H12O3), FTIR and NMR (CAS-539-88-8) data. A higher optimal reaction temperature (50鎺矯) and the reusability of CRL-ALG/NC/MMT for up to 9 esterification cycles substantiated the appreciable structural rigidification of the biocatalyst by ALG/NC/MMT, which improved the catalytic activity and thermal stability of the lipase.

Enzyme and Microbial Technology published new progress about Diutina rugosa. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Kuan-Liang; Kuo, Pei-Yu; Han, Jin-Lin; Hsieh, Kuo-Huang published the artcile< Influence of bioadditives made from sugarcane bagasse on interpenetrating polymer networks>, Category: esters-buliding-blocks, the main research area is sugarcane bagasse bioadditive interpenetrating polymer network dynamic mech analysis.

To achieve a sustainable bioeconomy, various bioderived additives have been developed to produce biocomposites, but only a handful of research on biocomposites focuses on the effect of bioderived additives on interpenetrating polymer networks (IPNs). This study is aimed at understanding the interaction between bioadditives and interpenetrating polymer networks and is the first study to build the relationship between bioadditive ratio and damping factor based on dynamic mech. anal. The IPNs were prepolymerized in bulk by isocyanate and poly(oxypropylene) polyol (PPG) with two different mol. weights (PPG 700 and PPG 1000), and then, they were grafted with bisphenol A diglycidyl ether epoxy. The bioadditives were prepared from agricultural waste, sugarcane bagasse, and the effect of the coupling agent 3- glycidoxypropyltrimethoxysilane on a bioadditive surface was also discussed in this study. The results show that modified bioadditives have significant enhancement on tensile strength and tensile modulus of polyurethane-grafted epoxy resin interpenetrating polymer networks (PU(PPG)-EP graft-IPNs). However, the enhancement is not from a strong covalent bond between matrix and additives, i.e., due to the well-dispersed bioadditives which provide stiff segments. The static and dynamic mech. performance, water absorption ratio, and morphol. of the (PU(PPG)-EP graft-IPNs) elastomers were also thoroughly discussed in this study.

International Journal of Polymer Science published new progress about Absorption (water). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Deletsu, Selase D.; Maina, Edward K.; Quaye, Osbourne; Ampofo, William K.; Awandare, Gordon A.; Bonney, Evelyn Y. published the artcile< High resistance to reverse transcriptase inhibitors among persons infected with human immunodeficiency virus type 1 subtype circulating recombinant form 02_AG in Ghana and on antiretroviral therapy>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is lamivudine zidovudine tenofovir antiretroviral agent human immunodeficiency virus type1.

This study sought to determine the dominant circulating human immunodeficiency virus type 1 (HIV-1) subtype and associated drug resistance mutations in Ghana.This cross-sectional study was conducted with archived samples collected from patients who received care at 2 hospitals in Ghana from 2014 to 2016. Blood samples were earlier processed into plasma and peripheral blood mononuclear cells and stored at -80鎺矯. RNA (RNA) was extracted from the archived plasma. Two HIV-1 genes; protease and reverse transcriptase, were amplified, sequenced using gene-specific primers and analyzed for subtype and drug resistance mutations using the Stanford HIV Database.Of 16 patient samples successfully sequenced, we identified the predominance of HIV-1 subtype CRF02_AG (11/16, 68%). Subtypes G (2/16, 13%), dual CRF02_AG/G (2/16, 13%), and CRF01_AE (1/16, 6%) were also observed Major nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations, M184I/V, D67N, T215F, and K70R/E were found. Non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance mutations, K103N, Y181C, V90I, F227L, and V106A were also prevalent. Addnl., and at a lower level, protease inhibitor (PI)-resistance mutations, M46I, I54V, V82A, L90M, and I471V, were also present in the sequences from antiretroviral therapy (ART)-experienced individuals. Two NRTI-associated drug resistance mutations (DRMs) (D67N and T69N) were present in sequences from 1 ART-naive individual.HIV-1 subtype CRF02_AG was most frequently detected in this study thus confirming earlier reports of dominance of this subtype in the West-African sub-region and Ghana in particular. The detection of these drug resistance mutations in individuals on first-line regimen composed of NRTI and NNRTI is an indication of prolonged drug exposure without viral load monitoring. Routine viral load monitoring is necessary for early detection of virol. failure and drug resistance testing will inform appropriate choice of regimens for such patients.

Medicine (Philadelphia, PA, United States) published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bogdanovskaya, Vera; Korchagin, Oleg published the artcile< Testing a Lithium-Oxygen (Air) Battery: Catalytic Properties of Positive Electrode Materials>, Formula: C19H34O2, the main research area is lithium oxygen air battery pos electrode catalytic property.

Although research in the field of lithium-oxygen (air) batteries (LOB) is rapidly developing, few comprehensive studies on the dependence of the catalytic properties of pos. electrode materials on LOB test conditions are present. In this paper, the influence of the c.d., the type of oxidizer (pure oxygen or air), and a solvent in the electrolyte (DMSO or tetraglyme) on the electrocatalytic properties of PtM/CNT systems (M = Ru, Co, Cr) used as a pos. electrode is investigated. It is shown that at a c.d. of 500 mA/g, more pronounced catalytic effects are observed during the LOB operation than that at 200 mA/g. The obtained results may be explained by the reduced adverse impact of surface passivation with lithium peroxide in the presence of catalysts compared to a similar effect when using unmodified carbon nanotubes (CNT). It is established that the influence of the c.d. on the catalytic properties continues upon the transition from oxygen to air as an oxidizer. When studying the effect of electrolytes on the catalytic properties of materials subjected to long-term LOB cycling, it is shown that the catalytic effects are most prominent when charged in a tetraglyme medium. Although using a catalyst has practically no effect on the number of cycles for both electrolytes, LOB having tetraglyme exceeds the cyclability of LOB having DMSO.

Batteries (Basel, Switzerland) published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohiaeri, Ejike E.; Odera, Stone R.; Onukwuli, Okechukwu D. published the artcile< The synthesis and optimization of a trimethylolpropane based biolubricant from alard oil base stock>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is optimization trimethylolpropane biolubricant lard oil base stock.

A lard oil based biolubricant was synthesized through a two stage transesterification reaction. Raw lard oil was synthesized with methanol using potassium hydroxide as catalyst to produce a Me ester for the first stage transesterification while the second stage involved the synthesis of the Me ester and trimethylolpropane with sodium methoxide as catalyst to produce the lard oil based TMP ester. The optimization of the lard oil based TMP ester was carried out using a central composite design (CCD) of response surface methodol. The optimal conditions for the various independent variables were reaction temperature of 130 鎺矯, mole ratio of 1:4, catalyst weight of 1.5%weight/weight and reaction time of 180mins for a corresponding lard oil based TMP ester yield of 93%. Anal. of variance (ANOVA) of the response showed a quadratic regression model with interacting independent variables. Regression coefficient (R2) of 0.972 and a standard deviation of 0.631 implies that 97.2% of the changes in the response can be explained by the regression model. The lubricating properties of the lard oil biolubricant are as follows: pour point of -10鎺矯, flash point of 229鎺矯, viscosity index of 2.32, sp. gr. of 0.92g/mL and kinematic viscosity of 40.51 and 10.22cSt at 40 鎺矯 and 100 鎺矯 resp. This study showed that the properties of the lard oil based TMP ester meets the ISO VG32 grade requirement and has its potential as a base oil for gear oil in automobiles.

Pharmaceutical and Chemical Journal published new progress about Composites (central design). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brito, Gilmar A.; Jung, Woo-Ok; Yoo, Minjin; Krische, Michael J. published the artcile< Enantioselective Iridium-Catalyzed Allylation of Acetylenic Ketones via 2-Propanol-Mediated Reductive Coupling of Allyl Acetate: C14-C23 of Pladienolide D>, SDS of cas: 112-63-0, the main research area is acetylenic ketone allylation enantioselective iridium catalyzed; pladienolide D fragment preparation enantioselective allylation; enantioselectivity; iridium; ketone allylation; transfer hydrogenation; é”?allyl.

Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14-C23 fragment (I) of pladienolide D in half the steps previously required.

Angewandte Chemie, International Edition published new progress about Alkynyl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghallab, Dina S.; Shawky, Eman; Ibrahim, Reham S.; Mohyeldin, Mohamed M. published the artcile< Comprehensive metabolomics unveil the discriminatory metabolites of some Mediterranean Sea marine algae in relation to their cytotoxic activities>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Ulva Pterocladia Sargassum Spirulina metabolomics metabolites anticancer.

Marine algae have served as a treasure trove of structurally variable and biol. active metabolites. The present study emphasizes on UPLC-MS metabolites fingerprinting for the first systematic broad scale metabolites characterization of three different phyla of marine seaweeds; Ulva fasciata, Pterocladia capillacea and Sargassum hornschuchii along with Spirulina platensis harvested from the Mediterranean Sea. A total of 85 metabolites belonging to various classes including mostly fatty acids and their derivatives, terpenoids, amino acids and dipeptides with considerable amounts of polyphenolic compounds OPLS-DA model offered a better overview of phylum-based discrimination rapidly uncovering the compositional heterogeneity in metabolite profiles of algae extracts An OPLS model was constructed using the cytotoxic activities against PC3 and MDA-MB-231 tumor cells to succinctly screen cytotoxic discriminatory metabolites among the tested algae species. The coefficient plot revealed that unsaturated fatty acids as stearidonic acid and linolenic acid, terpenoids namely as rosmanol, campestanol, dipeptides primarily glutamylglycine, glycyltyrosine along with polyphenolic compounds being abundantly present in S. platensis and U. fasciata samples with relatively marked cytotoxic potential might be the significant contributors synergistically meditating their anti-proliferative activity against PC3 and MDA-MB-231 tumor cells. Such results serve as baseline for understanding the chem. of these species and performing strict correlation between metabolite and activity where a lack of information in this regard is observed

Scientific Reports published new progress about Amino acids Role: BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), PUR (Purification or Recovery), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics