Category: 112-63-0

Kawashiri, Takehiro; Miyagi, Anna; Shimizu, Shiori; Shigematsu, Nao; Kobayashi, Daisuke; Shimazoe, Takao published the artcile< Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro>, Product Details of C19H34O2, the main research area is neurodegeneration dimethyl fumarate chemotherapy; Chemotherapy agents; Dimethyl fumarate; Neurotoxicity; Nuclear factor-erythroid-2-related factor 2 (Nrf2); Oxaliplatin.

Chemotherapy agents such as oxaliplatin, cisplatin, paclitaxel, and bortezomib frequently cause severe peripheral neuropathy and there is currently no effective strategy to prevent this. Di-Me fumarate (DMF) is a new oral drug for the treatment of multiple sclerosis, and has neuroprotective effects via up-regulation of the nuclear factor-erythroid-2-related factor 2 (Nrf2)-dependent antioxidant response. In this study, we investigated the effect of DMF on chemotherapy agent-induced neurodegenerations in cultured cells. We found that DMF and its metabolite monomethyl fumarate (MMF) attenuated oxaliplatin-, cisplatin-, and bortezomib- (but not paclitaxel-) induced inhibition of neurite outgrowth, but had no effect on cell death as a result of these agents in cultured PC12 cells and primary cultured rat dorsal root ganglion (DRG) neurons. Furthermore, Nrf2 DNA binding activity was increased by DMF and MMF in PC12 cells. These findings suggest that DMF, which activates Nrf2 pathway, has a potential protective action against chemotherapy-induced neurotoxicity, particularly neurite impairments.

Journal of Pharmacological Sciences (Amsterdam, Netherlands) published new progress about Atrophy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Minaei, Soraya Emamgholizadeh; Khoei, Samideh; Khoee, Sepideh; Mahdavi, Seied Rabi published the artcile< Sensitization of glioblastoma cancer cells to radiotherapy and magnetic hyperthermia by targeted temozolomide-loaded magnetite tri-block copolymer nanoparticles as a nanotheranostic agent>, Quality Control of 112-63-0, the main research area is glioblastoma cancer radiotherapy magnetic hyperthermia nanotheranostics temozolomide; magnetite triblock copolymer nanoparticles; Combination treatment; Hyperthermia; Nanoparticle; Radio-sensitizer; Radiotherapy; Thermo-sensitizer.

Recently, the development of new strategies in the treatment and diagnosis of cancer cells such as thermo-radiation-sensitizer and theranostic agents have received a great deal of attention. In this work, folic acid-conjugated temozolomide-loaded SPION@PEG-PBA-PEG nanoparticles (TMZ-MNP-FA NPs) were proposed for use as magnetic resonance imaging (MRI) contrast agents and to enhance the cytotoxic effects of hyperthermia and radiotherapy. Nanoparticles were synthesized by the Nano-precipitation method and their characteristics were determined by dynamic light scattering (DLS), SEM (SEM) and X-ray powder diffraction (XRD). To evaluate the thermo-radio-sensitization effects of NPs, C6 cells were treated with nanoparticles for 24 h and then exposed to 6-MV X-ray radiation. After radiotherapy, the cells were subjected to an alternating magnetic field (AMF) hyperthermia. The therapeutic potential was assessed using clonogenic assay, ROS generation measurement, flow cytometry assay, and qRT-PCR anal. Also, the diagnostic properties of the nanoparticles were assessed by MRI. MRI scanning indicated that nanoparticles accumulated in C6 cells could be tracked by T2-weighted MR imaging. Colony formation assay proved that TMZ-MNP-FA NPs enhanced the anti-proliferation effects of AMF by 1.94-fold compared to AMF alone (P < 0.0001). Moreover, these NPs improved the radiation effects with a dose enhancement factor of 1.65. All results showed that the combination of carrier-based chemotherapy with hyperthermia and radiotherapy caused a higher anticancer efficacy than single- or two-modality treatments. The nanoparticles advanced in this study can be proposed as the promising theranostic and thermo-radio-sensitizer platform for the diagnosis and tri-modal synergistic cancer therapy. Life Sciences published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wemken, Gregor; Spies, Benedikt Christopher; Pieralli, Stefano; Adali, Ufuk; Beuer, Florian; Wesemann, Christian published the artcile< Do hydrothermal aging and microwave sterilization affect the trueness of milled, additive manufactured and injection molded denture bases>, Computed Properties of 112-63-0, the main research area is denture base additive manufacturing hydrothermal cycling microwave sterilization; Accuracy; Additive manufacturing; CAD-CAM; Complete denture; Polymers.

To assess trueness of IM, MIL, and stereolithog. printed denture bases after manufacturing, hydrothermal cycling, and microwave sterilization. 16 Edentulous maxillary plaster models were poured using silicone mold and digitized by means of desktop scanner. For group IM, 16 denture bases were injection molded. MIL and SLA, denture bases were virtually designed and manufactured referring to digitized data. A total of 48 samples were scanned 1) after manufacturing, 2) after hydrothermal cycling three as well as 4) six cycles of microwave sterilization for 6 min each at 640 W. The 3D surface deviation of the total intaglio surface, the palate, the alveolar ridge, and the border seal region was evaluated on basis of RMSE and pos. and neg. mean deviations with inspection software. In comparison, IM showed increased, mainly pos., deviations at border seal. SLA presented highest total RMSE with increased neg. deviations, likewise at the border seal. In contrast to SLA, no differences between IM and MIL were measured after hydrothermal cycling. Following microwave sterilization, the trueness of SLA was higher compared to IM and MIL with no differences between MIL and IM. Distortion of IM and MIL was measured after the 3rd cycle with no further changes observed Subtractive manufacturing of denture bases results in the highest trueness, followed by IM and SLA. IM and SLA, hydrothermal cycling did not affect MIL. SLA printed denture bases remained dimensionally stable after microwave sterilization.

Journal of the Mechanical Behavior of Biomedical Materials published new progress about Additive manufacturing. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wong, Man Shing; Li, Zhong Hui; Tao, Ye; D’Iorio, Marie published the artcile< Synthesis and Functional Properties of Donor-Acceptor π-Conjugated Oligomers>, Product Details of C19H34O2, the main research area is function property donor acceptor pi conjugation oligomer synthesis.

Novel donor-acceptor oligophenylenevinylenes (OPVs) bearing an electron-donating 2-(2-butoxyethoxy)ethoxy group at one end and various electron-withdrawing groups including alkylsulfonyl, cyano, and nitro functionalities at the other end have been synthesized for investigation of structure-functional property relationships. Depending on the nature of the electron-withdrawing group, the newly synthesized donor-acceptor OPVs can exhibit an efficient light-emitting property or a large photovoltaic effect. The asym. disubstituted OPV bearing 2-(2-butoxy-ethoxy)ethoxy-hexylsulfonyl functionalities possesses superior mol. properties for light-emitting applications than the sym. 2-(2-butoxyethoxy)ethoxy-disubstituted counterparts. In addition, our first observation and investigation on the photovoltaic response in polyalkyleneoxy-nitro disubstituted OPV series is reported. The spectral response of the photovoltaic device corresponds to the absorption characteristics of the oligomer. Most importantly, the photocurrent response increases with an extension of the conjugated length of the oligomer.

Chemistry of Materials published new progress about Conjugation (bond) (pi). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Iriarte, Igor; Vera, Silvia; Badiola, Eider; Mielgo, Antonia; Oiarbide, Mikel; Garcia, Jesus M.; Odriozola, Jose M.; Palomo, Claudio published the artcile< Asymmetric Assembly of All-Carbon Tertiary/Quaternary Nonadjacent Stereocenters through Organocatalytic Conjugate Addition of α-Cyanoacetates to a Methacrylate Equivalent>, Reference of 112-63-0, the main research area is organocatalytic conjugate addition cyanoacetate methacrylate equivalent; Brønsted bases; Michael reactions; asymmetric organocatalysis; quaternary stereocenters; stereoselective protonation.

An efficient, highly diastereo- and enantioselective assembly of acyclic carbonyl fragments possessing nonadjacent all-carbon tertiary/quaternary stereoarrays is reported based on a Bronsted base catalyzed Michael addition/α-protonation sequence involving α-cyanoacetates and 2,4-dimethyl-4-hydroxypenten-3-one as novel methacrylate equivalent

Chemistry – A European Journal published new progress about Carbonyl compounds (organic) Role: SPN (Synthetic Preparation), PREP (Preparation) (acyclic). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Park, Kyung-Ho; Cho, Sung Yun; Kim, Sung Soo; Yum, Eul Kgun; Yu, Chan-Mo; Hwang, Ki-Jun published the artcile< Novel migration of aryl group in 3-trifluoromethylpyrazolyl aryl ether>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is pyrazolyl aryl ether rearrangement.

In title compounds I (R = aryl), the aryl group migrated from O to N in the presence of base.

Bulletin of the Korean Chemical Society published new progress about Rearrangement. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xiaosong; Yu, Xiaojun; Xu, Haoran; Wei, Kang; Wang, Shanxi; Wang, Yingguang; Han, Junfei published the artcile< Serum-derived extracellular vesicles facilitate temozolomide resistance in glioblastoma through a HOTAIR-dependent mechanism>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Abstract: Extracellular vesicle (EV)-mediated transfer of long non-coding RNAs (lncRNAs) has been reported to regulate chemoresistance in various cancers. We herein investigate the therapeutic potential of bioinformatically identified HOTAIR transferred by serum-derived EVs (serum-EVs) in temozolomide (TMZ) resistance of glioblastoma (GBM) and the downstream mechanisms. EVs were isolated from the serum of GBM patients. Expression of HOTAIR was examined in the clin. tissue samples and serum-EVs of GBM patients. The downstream miRNAs of HOTAIR and its target genes were predicted in silico. The effects of the HOTAIR transmitted by serum-EVs in malignant phenotypes, tumor growth, and TMZ resistance were assessed in vitro and in vivo. HOTAIR expression was upregulated in clin. tissues, cells, and serum-EVs of GBM. Co-culture data showed that GBM-serum-EVs facilitated GBM cell proliferative and invasive phenotypes and TMZ resistance by elevating HOTAIR. In GBM cells, HOTAIR competitively bound to miR-526b-3p and weakened miR-526b-3p′s binding ability to EVA1, thus increasing the expression of EVA1. Furthermore, HOTAIR carried by serum-EVs promoted tumor growth and TMZ resistance in vivo by suppressing miR-526b-3p-mediated EVA1 inhibition. GBM-serum-EV-enclosed HOTAIR may augment GBM progression and chemoresistance through miR-526b-3p downregulation and EVA1 upregulation. These results provide a strategy to reduce TMZ resistance in GBM treatment.

Cell Death & Disease published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sugiyama, H.; Yokokawa, F.; Aoyama, T.; Shioiri, T. published the artcile< Synthetic studies of N-reverse prenylated indole. An efficient synthesis of antifungal indole alkaloids and N-reverse prenylated tryptophan>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is reverse prenylated indole preparation; antifungal alkaloid reverse prenylated tryptophan.

The efficient method for the synthesis of N-1,1-dimethyl-2-propenyl (reverse prenyl) indole was developed by the N-propargylation of the indoline, partial hydrogenation of the terminal alkyne, and oxidation to the indole using chem. manganese dioxide (CMD). This method was used for the synthesis of the antifungal indole alkaloids I, II, and N-reverse prenylated tryptophan.

Tetrahedron Letters published new progress about Fungicides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A. published the artcile< Amine derivatives of pyrrolo[3,2-d]pyrimidines>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is pyrrolopyrimidinamine derivative preparation structure pharmacol.

A series of 28 derivatives (I; R1 = Me, Cl, amino; R2 = Cl, amino; R3 = H, Ph; R4 = H, aminomethyl) was prepared by reactions of the chloro derivatives of pyrrolo[3,2-d]pyrimidines with an appropriate amine. Toxicity and antitumor, antibacterial, and antifungal activities of I were tested in mice, rats, and in vitro in cultures of Staphylococcus aureus, Escherichia coli, Microsporum canis, and Candida albicans. Most I had some antitumor activity against implanted sarcomas, melanomas, and carcinomas. No I was active against E. coli, M. canis, or C. albicans. Toxicity of I varied with LD50 = 50->500 mg/kg.

Khimiko-Farmatsevticheskii Zhurnal published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bokhonov, B. B.; Burleva, L. P.; Frank, W. C.; Miller, J. R.; Mizen, M. B.; Sahyun, M. R. V.; Whitcomb, D. R.; Winslow, J. M.; Zou, C. published the artcile< Morphological regularities in the formation of silver halides during in situ halidization of silver stearate>, COA of Formula: C19H34O2, the main research area is silver stearate silver halide interface photog; photothermog silver stearate silver halide interface.

The results of an investigation of the sites of silver halide formation on the surface of silver carboxylate crystals, modeled by silver stearate and prepared by the standard in situ process used for thermally developed photog. materials, are reported. For the first time the structure of a silver halide/silver carboxylate interface has been clearly observed Silver bromide is found to form on the edges of the silver stearate crystal during the initial stages of the reaction. The influence of the nature of the halide source on the silver halide shape and location on the silver carboxylate crystal and the presence of defects in the silver halide crystals are discussed.

Journal of Imaging Science and Technology published new progress about Crystallization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics