Category: 112-63-0

Asaula, Vitalii M.; Buryanov, Volodymyr V.; Solod, Bohdan Y.; Tryus, Daryna M.; Pariiska, Olena O.; Kotenko, Igor E.; Volovenko, Yulian M.; Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V.; Kolotilov, Sergey V. published the artcile< Catalytic Hydrogenation of Substituted Quinolines on Co-Graphene Composites>, Related Products of 112-63-0, the main research area is quinoline preparation catalytic hydrogenation cobalt graphene composite.

A set of 20 composites was prepared by pyrolysis of Co2+ complexes with 1,10-phenanthroline, melamine and 1,2-diaminobenzene. These composites were tested as the catalysts for the hydrogenation of quinolines. As shown by powder X-ray diffraction and TEM, the composites contained Co particles of several dozen nm sizes. The composition (elements content), Raman spectra X-ray photoelectron spectra parameters of the composites were analyzed. It was found that there was no distinct factor that controlled the yield of 1,2,3,4-tetrahydroquinolines in the investigated process. The yields of the resp. products were in the range 90-100%. The three most active composites were selected for scale-up and hydrogenation of a series of substituted quinolines. Up to 97% yield of 1,2,3,4-tetrahydroquinoline was obtained on a 50 g scale. Five representative substituted quinolines were synthesized on a 10-20 g scale using the Co-containing composites as the catalysts.

European Journal of Organic Chemistry published new progress about Hydrogenation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mao, Meng; Chu, Qinjun; Lou, Yongli; Lv, Peipei; Wang, Lin-Jian published the artcile< RNA N1-methyladenosine regulator-mediated methylation modification patterns and heterogeneous signatures in glioma>, Computed Properties of 112-63-0, the main research area is glioma methylation RNA N1methyladenosine; TMZ-resistance; glioma; heterogeneity; m1A; stemness; tumor microenvironment.

N1-methyladenosine (m1 A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1 A modification-related patterns based on m1 A regulators in the TCGA (The Cancer Genome Atlas) and CGGA (Chinese Glioma Genome Atlas) cohorts. The differences in survival prognosis between different clusters were striking. In addition, stemness, genomic heterogeneity, tumor microenvironment (TME), and immune cell infiltration were also significantly different between the poor and best prognostic clusters. To reveal the underlying mechanism, differentially expressed genes (DEGs) between the poor and best prognostic clusters were identified, and then were integrated for weighted correlation network anal. (WGCNA). After Univariate Cox-LASSO-Multivariate Cox analyses, DEGs PLEK2 and ABCC3 were screened as the risk-hub genes and were selected to construct an m1 A-related signature. Moreover, ABCC3 exacerbated glioma proliferation and was associated with temozolomide (TMZ) resistance. Overall, our study provided new insights into the function and potential therapeutic role of m1 A in glioma.

Frontiers in Immunology published new progress about CD4 antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Yumei; Wang, Tieshan; Zhao, Xiaoshan; Wang, Ji; Wang, Qi published the artcile< Plasma metabolites and gut microbiota are associated with T cell Imbalance in BALB/c model of eosinophilic asthma>, Application of C19H34O2, the main research area is metabolite immunity eosinophilic allergy asthma; Tcell imbalance; drug treatment; eosinophilic asthma; gut microbiota; plasma metabolites.

The pathogenesis of allergic asthma is complex, it is usually caused by immune system imbalance. Th1, Th2, regulatory T cells (Treg) and T helper 17 (Th17) cells have an important role in the pathogenesis of eosinophilic asthma. Yet, the exact role of Th1, Th2, Treg and Th17 cells in eosinophilic asthmatic disease is not fully understood. This study used an untargeted plasma metabolomics combine 16S rDNA technol. to identify new biomarkers of plasma metabolites and gut microbiota in ovalbumin-induced eosinophilic allergic asthma in BALB/c mice to further explore the biomarkers in regulating the immune balance or the immune response. We discovered that malate, L-dihydroorotate were associated with Th1/Th2 and Treg/Th17 cells balance, imidazoleacetic acid was associated with Th1/Th2 cell balance, 1,5-anhydro-d-sorbitol was associated with Treg/Th17 cell balance. The results also found that genus Candidatus Arthromitus of gut microbiota were associated with Th1/2, Treg/Th17 balance, genus Ruminiclostridium 6, they were all associated with Th1/2 and Treg/Th17 cell balance, while the gut microbiota were not associated with penh value which reflect airway hyperresponsiveness (AHR) in the eosinophilic asthma mice model. Interestingly, the plasma metabolite biomarkers of malate, L-dihydroorotate are associated with genus Ruminiclostridium 6, they were all associated with Th1/2 and Treg/Th17 cell balance, while imidazoleacetic acid is associated with genus Ruminiclostridium 6 which is associated with Th1/2 balance. Among the differential plasma metabolites, 1,5-anhydro-d-sorbitol is associated with genus Ruminiclostridium6 and genus Candidatus Arthromitus. Among them, malate participate in the T cell activation, T cell differentiation and activation may be a new research direction in eosinophilic allergic asthma. We firstly study the gut microbiota and plasma metabolites markers of immune balance in eosinophilic asthma in mice model, laying a foundation for drug treatment in eosinophilic allergic asthma.

Frontiers in Pharmacology published new progress about Allergic asthma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cui, Pei H.; Rawling, Tristan; Bourget, Kirsi; Kim, Terry; Duke, Colin C.; Doddareddy, Munikumar R.; Hibbs, David E.; Zhou, Fanfan; Tattam, Bruce N.; Petrovic, Nenad; Murray, Michael published the artcile< Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antitumor antimetastatic monounsaturated fatty acid preparation breast cancer; structure activity antitumor monounsaturated fatty acid preparation breast cancer.

Cyclooxygenase-2 (COX-2) is overexpressed in many human cancers and converts the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid to prostaglandin E2 (PGE2), which drives tumorigenesis; in contrast, n-3 PUFA inhibit tumorigenesis. We tested the hypothesis that these antitumor actions of n-3 PUFA may involve the n-3 olefinic bond. n-3 Monounsaturated fatty acids (MUFAs) of chain length C16-C22 were synthesized and evaluated in MDA-MB-468 breast cancer cells that stably overexpressed COX-2 (MDA-COX-2 cells). Longer chain (C19-C22) n-3 MUFAs inhibited proliferation, activated apoptosis, decreased PGE2 formation, and decreased cell invasion; C16-C18 analogs were less active. Mol. modeling showed that interactions of Arg120, Tyr355, and several hydrophobic amino acid residues in the COX-2 active site with C19-C22 MUFA analogs were favored. Thus, longer-chain n-3 MUFAs may be prototypes of novel anticancer agents that decrease the formation of PGE2 in tumor cells that contain high levels of COX-2.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Li; Zhu, Huayu; Song, Xingliang; Sun, Aide published the artcile< Analysis of chemical components in essential oil of the Negundo Chastetree fruit of supercritical CO2 fluid extraction by gas chromatography/mass spectrometry>, Related Products of 112-63-0, the main research area is Negundo carbon dioxide GC MS essential oil.

The chem. compositions in essential oil of the Negundo Chastetree Fruit of supercritical CO2 fluid extraction were analyzed. The chem. compositions of the volatile oil of the Negundo Chastetree Fruit extracted by supercritical CO2 fluid were analyzed by capillary gas chromatog.-mass spectrometry (GC-MS) method, and the relative component percentage of each component was determined by GC area normalization method. Ninety-one peaks were separated by capillary GC-MS and of the 60 peaks corresponding compounds were identified, which account for about 96% of the total area. The main chem. compositions were as follows: decanol (71.22%), 2,5,5,8a-tetramethyloctahydro-2H-chromene (4.96%), β-caryophyllene (2.29%), cyclohexene (1.86%), osthole (1.77%), 4-hydroxy-4-methyl-2-pentanone (1.61%) and 9-(3-butenyl) anthracene (1.11%), etc. This study could be served as a scientific basis for the further exploitation and utilization of the Negundo Chastetree Fruit.

Zhongguo Yaofang published new progress about Negundo. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Chunsheng; Zhong, Chongli published the artcile< Chirality factors and their application to QSAR studies of chiral molecules>, Category: esters-buliding-blocks, the main research area is chirality factor QSAR.

Two series of chirality factors that can distinguish enantiomers and diastereomers were developed in this work and the corresponding chiral topol. indexes were proposed. The obtained chiral topol. indexes can be used to perform QSAR studies for chiral mols. The biol. activities of fourteen 3-(3-hydroxyphenyl)- piperidines (seven pairs of enantiomers), the high-pressure thin-layer chromatog. retention indexes of eight hydroxy acids and ten amino acids (nine pairs of enantiomers), the ED50 of 23 ecdysteroids (19 pairs of diastereomers), and the corticosteroid-binding globulins affinities of 31 steroids were used to evaluate the chirality factors and the corresponding chiral topol. indexes. The QSAR models developed give satisfactory predictive accuracy. Compared with the existing methods, the chirality factor method proposed in this work has the advantage of being applicable to the existing topol. indexes directly. This makes good use of the existing topol. indexes, and thus brings convenience to the QSAR studies for chiral mols. Another advantage of the new method is that it can also correctly describe the characteristics of meso compounds

QSAR & Combinatorial Science published new progress about Chirality. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tian, Lu; Zhang, Luxin; Liu, Yuting; He, Yunfei; Zhu, Yujie; Sun, Ruijun; Yi, Simin; Xiang, Junping published the artcile< Clean production of ethyl levulinate from kitchen waste>, Product Details of C19H34O2, the main research area is kitchen waste ethyl levulinate heterogeneous catalyst physicochem property.

A clean and highly efficient catalytic system for the synthesis of Et levulinate (EL) from kitchen waste was developed. A heterogeneous catalyst (Sn/ZrP-SO3H) was prepared and the Bronsted and Lewis acid sites on the surface of the catalyst were evaluated by pyridine FT-IR. Other physicochem. properties were also characterized using XRD, SEM, FT-IR, XPS, BET, NH3-TPD. The yield of EL obtained was 49.27%, when glucose was used as the starting material and subjected to 170°C for 10 h in the presence of the solid acid catalyst, Sn/ZrP-SO3H. The prepared catalyst was also combined with several metal triflates; (Al(OTf)3, Fe(OTf)3, Sm(OTf)3) to form a catalytic system for the efficient preparation of EL from kitchen waste. Sn/ZrP-SO3H/Al(OTf)3 had superior activity compare to other catalyst combinations. In single factor experiments, the yield of EL reached 52.52% after heating at 170°C for 4 h. In addition, four-factor and three-level experiments were performed using response surface methodol. (RSM) to analyze the interaction between each factor. The optimal reaction conditions predicted by the model (163°C, 7.63 h, 20 mg Al(OTf)3, 40 mg Sn/ZrP-SO3H and 79.98 mg of kitchen waste) estimated a maximal yield for EL of 51.24%. The exptl. yield of EL however was 52.03% which confirms the reliability of the model. This work provides a cleaner production technol. for the synthesis of the high value-added chem. EL, and a sustainable route for the utilization of kitchen waste.

Journal of Cleaner Production published new progress about Polymer surface morphology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Calter, Michael A.; Phillips, Ryan M.; Flaschenriem, Christine published the artcile< Catalytic, Asymmetric, ""Interrupted"" Feist-Benary Reactions>, Formula: C19H34O2, the main research area is hydroxydihydrofuran preparation catalytic asym interrupted Feist Benary.

Pyrimidine derivatives of the cinchona alkaloids function as excellent asym. catalysts for the interrupted Feist-Benary reaction. This reaction produces highly substituted hydroxydihydrofurans from simple starting materials under mild conditions. The asym. reaction gives high enantioselectivities with unsubstituted bromoketones and high enantio- and diastereoselectivities with substituted substrates. Mechanistic experiments suggest that the hydrobromide salt of the alkaloid derivative is the active catalyst for the reaction.

Journal of the American Chemical Society published new progress about Condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gangane, Purushottam Shridhar; Pachpute, Tejas; Mahapatra, Debarshi Kar; Mahajan, Nilesh Manoharrao published the artcile< HPMC polymers and xanthan gum assisted development and characterization of stavudine extended release floating tablets>, HPLC of Formula: 112-63-0, the main research area is xanthan gum assisted development extended release floating tablet.

Stavudine has a low half-life of 0.8-1.5 h and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order to enhance and preserve the stable drug level of stavudine for round the clock, gastroretentive systems (floating low-d. formulations that cause buoyancy on the gastric fluid in the stomach) may prove to be advantageous for releasing the drug content from the matrix tablet reservoirs for several hours. The current research endeavors towards formulating the stavudine floating tablet formulations (F1-F9) employing rate modifying polymers such as HPMC K15M, xanthan gum and HPMC K100M using multiple punch tablet compression machine containing 9 mm diameter, round flat-faced punches to form 80 mg tablet with a batch size of 100. The drug-polymer compatibility was investigated through Fourier-Transformed IR Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The stavudine floating tablet formulations were successfully fabricated. The pre-compression characteristics (tapped d., bulk d., Hausner’s ratio, Carr’s index and angle of repose) as well as postcompression characteristics (appearance, hardness, dimension, drug content, friability, swelling index, weight variation, in vitro drug release, in vitro buoyancy, accelerated stability and drug release kinetics for 90 days) of the formulations were comprehensively studied. This research study on stavudine will definitely open several new milestones for anti-retroviral pharmacotherapeutics in the upcoming future perspectives by enhancing the half-life of the drug employing the floating extended-release attributes.

Indian Journal of Pharmaceutical Education and Research published new progress about Artificial gastric juice. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selvakumar, N.; Azhagan, A. Malar; Srinivas, D.; Krishna, G. Gopi published the artcile< A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: a short synthesis of (±)-coerulescine and (±)-horsfiline>, Category: esters-buliding-blocks, the main research area is coerulescine synthesis; horsfiline synthesis; arylpropenoic acid ester nitro preparation; propenoic acid ester arylnitro preparation.

A short synthesis of 2-arylpropenoic acid esters that possess nitro groups in their Ph ring using common and less expensive reagents is described. The usefulness of this methodol. is substantiated by the efficient total syntheses of (±)-coerulescine (I) and (±)-horsfiline from the 2-arylpropenoic acid esters obtained.

Tetrahedron Letters published new progress about Nitro group. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics