Category: 110-42-9

Mhlongo, Msizi I. published the artcileProfiling of Volatile Organic Compounds from Four Plant Growth-Promoting Rhizobacteria by SPME-GC-MS: A Metabolomics Study, Safety of Methyl decanoate, the main research area is PGPR volatile organic compound metabolomics profiling SPME GCMS; metabolomics profiling; multivariate data analysis (MVDA); plant growth promoting rhizobacteria (PGPR); solid-phase micro-extraction gas chromatography mass spectrometry (SPME–GC–MS); volatile organic compounds (VOCs).

The rhizosphere microbiome is a major determinant of plant health. Plant-beneficial or plant growth-promoting rhizobacteria (PGPR) influence plant growth, plant development and adaptive responses, such as induced resistance/priming. These new eco-friendly choices have highlighted volatile organic compounds (biogenic VOCs) as a potentially inexpensive, effective and efficient substitute for the use of agrochems. Secreted bacterial VOCs are low mol. weight lipophilic compounds with a low b.p. and high vapor pressures. As such, they can act as short- or long-distance signals in the rhizosphere, affecting competing microorganisms and impacting plant health. In this study, secreted VOCs from four PGPR strains (Pseudomonas koreensis (N19), Ps. fluorescens (N04), Lysinibacillus sphaericus (T19) and Paenibacillus alvei (T22)) were profiled by solid-phase micro-extraction gas chromatog. mass spectrometry (SPME-GC-MS) combined with a multivariate data anal. Metabolomic profiling with chemometric analyses revealed novel data on the composition of the secreted VOC blends of the four PGPR strains. Of the 121 annotated metabolites, most are known as bioactives which are able to affect metabolism in plant hosts. These VOCs belong to the following classes: alcs., aldehydes, ketones, alkanes, alkenes, acids, amines, salicylic acid derivatives, pyrazines, furans, sulfides and terpenoids. The results further demonstrated the presence of species-specific and strain-specific VOCs, characterized by either the absence or presence of specific VOCs in the different strains. These mols. could be further investigated as biomarkers for the classification of an organism as a PGPR and selection for agricultural use.

Metabolites published new progress about Alcohols Role: ANT (Analyte), PUR (Purification or Recovery), ANST (Analytical Study), PREP (Preparation). 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Safety of Methyl decanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alexpandi, Rajaiah published the artcileAnti-QS mediated anti-infection efficacy of probiotic culture-supernatant against Vibrio campbellii infection and the identification of active compounds through in vitro and in silico analyses, Recommanded Product: Methyl decanoate, the main research area is Vibrio campbellii infection probiotic culture supernatant active compound QS.

The main intent of the present study was to identify the novel anti-quorum sensing (anti-QS) compounds from probiotic product (Rhodomax) and assess their anti-infection effect of against Vibrio campbellii infection using tomato clownfish (Amphiprion frenatus). In this study, rhodomax probiotic-product was investigated for its active compounds’ prediction through in silico anal. Initially, anti-QS activity of probiotic-supernatant was authenticated by decrease in bioluminescence production of V. campbellii. As expected, the probiotic-supernatant effectively inhibited the biofilm formation, swimming motility, and hydrophobicity of V. campbellii at 20μg/mL concentration During in vivo trail with tomato clownfish, probiotic-supernatant (20 ppm) treatment showed a significant increase in the survival rates to the level of 88% against V. campbellii infection. Further, the reduced colonization of V. campbellii inside the probiotic-supernatant treated animals correlates the anti-infection activity. The histopathol. differences in tissue levels such as the gill, intestine, and kidney of infected and probiotic-supernatant treated animals were also support the in-vivo trial, which strongly revealed the disease protection of rhodomax-supernatant against V. campbellii infection. Notably, the docking anal. revealed that the anti-QS mediated anti-infection activity of rhodomax-supernatant against V. campbellii infection is accomplished by the presence of active metabolites such as,4-Dihydro-7-methoxy-2,2-dimethyl-2H-1-benzopyran-3,4-diol and Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-3-(1-methylethyl). Hence, we suggest that these two active metabolites could be the novel alternative agents to control V. campbellii-associated infections in aquaculture.

Biocatalysis and Agricultural Biotechnology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Recommanded Product: Methyl decanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Batista, Ellencristina Silva published the artcileOmega-3 mechanism of action in inflammation and endoplasmic reticulum stress in mononuclear cells from overweight non-alcoholic fatty liver disease participants: study protocol for the “”Brazilian Omega Study”” (BROS)-a randomized controlled trial, Recommanded Product: Methyl decanoate, the main research area is omega action mechanism inflammation endoplasmic reticulum stress; mononuclear cell overweight non alc fatty liver disease human; Endoplasmic reticulum stress; GPR120; Inflammation; NAFLD; Omega-3; Overweight.

The low-grade inflammation is pivotal in obesity and its comorbidities; however, the inflammatory proteins are out of target for traditional drug therapy. Omega-3 (ω3) fatty acids can modulate the downstream signaling of Toll-like receptor (TLR) and tumor necrosis factor-α receptor (TNFα) through GPR120, a G-protein-coupled receptor, a mechanism not yet elucidated in humans. This work aims to investigate if the ω3 supplementation, at a feasible level below the previously recommended level in the literature, is enough to disrupt the inflammation and endoplasmic reticulum stress (ER-stress), and also if in acute treatment (3 h) ω3 can activate the GPR120 in peripheral blood mononuclear cells (PBMC) and leukocytes from overweight non-alc. fatty liver disease (NAFLD) participants. The R270H variant of the Ffar4 (GPR120 gene) will also be explored about mol. responses and blood lipid profiles. A triple-blind, prospective clin. trial will be conducted in overweight men and women, aged 19-75 years, randomized into placebo or supplemented (2.2 g of ω3 [EPA+DHA]) groups for 28 days. For sample calculation, it was considered the variation of TNFα protein and a 40% dropout rate, obtaining 22 individuals in each group. Volunteers will be recruited among patients with NAFLD diagnosis. Anthropometric parameters, food intake, phys. activity, total serum lipids, complete fatty acid blood profile, and glycemia will be evaluated pre- and post-supplementation. In the PBMC and neutrophils, the protein content and gene expression of markers related to inflammation (TNFα, MCP1, IL1α, IL6, IL10, JNK, and TAK1), ER-stress (ATF1, ATF6, IRE1, XBP1, CHOP, eIF2α, eIF4, HSP), and ω3 pathway (GPR120, β-arrestin2, Tab1/2, and TAK1) will be evaluated using Western blot and RT-qPCR. Participants will be genotyped for the R270H (rs116454156) variant using the TaqMan assay. It is hypothesized that attenuation of inflammation and ER-stress signaling pathways in overweight and NAFLD participants will be achieved through ω3 supplementation through binding to the GPR120 receptor.

Trials published new progress about Activating transcription factor 6α Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Recommanded Product: Methyl decanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hamdan, Dalia I. published the artcileEchinops taeckholmiana Amin: Optimization of a Tissue Culture Protocol, Biological Evaluation, and Chemical Profiling Using GC and LC-MS, Category: esters-buliding-blocks, the main research area is Echinops tissue culture metabolite.

There have been no reports published on the rare Echinops taeckholmiana growing wildly in Egypt. So, this study aimed to preserve it through method optimization of in vitro seed germination, besides callus formation from induced seedlings. Chem. profiling using gas chromatog.-mass spectrometry (GC-MS) anal. of the n-hexane fraction afforded 29 identified components, mainly fatty acids esters, sesquiterpenes, triterpenes, one thiophene, and bis(2-ethylhexyl) phthalate. Ultra-performance liquid chromatog.-electron spray ionization/tandem mass spectrometry (UPLC-ESI/MS-MS) anal. of total alc. root and induced calli extracts resulted in 68 metabolites. Taraxeryl acetate, β-sitosterol, stigmasterol-3β-D-glucoside, and 1,1,1-kestopentaose were identified from the defatted root extract, which inhibited α-amylase (IC50 54.6 μg/mL) and α-glucosidase (60.4 μg/mL) enzymes compared with acarbose (IC50 values of 30.57 and 34.71 μg/mL, resp.). Moreover, it showed moderate activity against HepG2 (IC50 31.1 ± 1.4 μg/mL) and no activity against M-NFS-60 cell lines compared to cisplatin (IC50 3.25 ± 1.4 and 8.37 ± 0.25, resp.).

ACS Omega published new progress about Cytotoxic agents. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haarmann, Niklas published the artcileMeasurement and Prediction of Excess Properties of Binary Mixtures Methyl Decanoate + an Even-Numbered n-Alkane (C6-C16) at 298.15 K, HPLC of Formula: 110-42-9, the main research area is excess property binary mixture methyl decanoate alkane prediction measurement.

The molar excess volumes vE of the three binary mixtures Me decanoate + n-alkane (n-dodecane, n-tetradecane, and n-hexadecane) were measured at temperature T = 298.15 K and atm. pressure using a vibrating tube densitometer. Furthermore, the molar excess enthalpies hE of the six binary mixtures Me decanoate + n-alkane (n-hexane, n-octane, n-decane, n-dodecane, n-tetradecane, and n-hexadecane) were measured at the same ambient conditions using a Calvet microcalorimeter. Both excess properties showed an increase with the increasing chain length of the n-alkane. Two equations of state, i.e., a heterosegmental approach of Perturbed Chain Statistical Associating Fluid Theory (PC-SAFT) and SAFT-γ Mie, were applied to predict the excess properties of the resp. binary mixtures Very satisfying agreement between the exptl. data and modeling results was obtained for both equations of state.

Journal of Chemical & Engineering Data published new progress about Binary mixtures, liquid. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, HPLC of Formula: 110-42-9.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Yao published the artcileEffects of spontaneous fermentation on the microorganisms diversity and volatile compounds during ‘Marselan’ from grape to wine, Application of Methyl decanoate, the main research area is spontaneous fermentation volatile compound marselan grape wine.

‘Marselan is a promising wine grapevine with unique qualities, studies on its introduction and characteristics have never stopped. However, little is known about the fermentation process of ‘Marselan wine. In this study, we compared industrial-scale spontaneous (SMF) and inoculated (IMF) fermentation processes on the succession of microbial community and the change in volatile compounds and predicted their correlations. SMF could ferment ‘Marselan to dry red wine with alc. content of 13.37% ± 0.76% (volume/volume) in 10 days and enhance the total concentration and odor activity values (OAVs) of volatile compounds Et caprylate, Et caprate, Et caproate and citronellol (OAVs > 1.0) were important volatile compounds in SMF and IMF wines. Compared with IMF, SMF was more outstanding in initial non-Saccharomyces diversity, including Hanseniaspora, Metschnikowia and Issatchenkia. In addition, Spearmans correlation (|ρ| > 0.7) and bidirectional orthogonal partial least squares (O2PLS, VIP > 1.0) anal. showed that some indigenous microorganisms in grape were closely related to the formation of volatile compounds, such as lactic acid bacteria, non-Saccharomyces and Saccharomyces cerevisiae. Overall, results showed that SMF could strengthen the flavor of ‘Marselan’ wine, and the possibility of consideration screening indigenous aroma-producing microorganisms as starter to improve the unique characteristics of ‘Marselan wine.

LWT–Food Science and Technology published new progress about Alcohols Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Application of Methyl decanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balthazar, Celso F. published the artcileEffect of probiotic Minas Frescal cheese on the volatile compounds profile and metabolic profile assessed by nuclear magnetic resonance spectroscopy and chemometric tools, HPLC of Formula: 110-42-9, the main research area is cheese probiotics volatile compound metabolic profile NMR spectroscopy chemometrics; Lacticaseibacillus casei 01; amino acid; chemometrics; fresh cheese; probiotic.

This study aimed to evaluate the effect of Lacticaseibacillus casei 01 as a probiotic culture on the production of volatile organic compounds and metabolic profile of Minas Frescal cheese. Lactose (α-lactose and β-lactose), fatty acids (unsaturated and saturated), citric acid, tryptophan, and benzoic acid were the main compounds Compared with the control cheese, probiotic cheese was characterized by the highest concentration of tryptophan and presented a higher number of volatile acids. The control cheese was characterized by the highest concentration of benzoic acid and fatty acids, resulting in a higher number of volatile alcs. and esters. No differences were observed for α-lactose, β-lactose, and citric acid contents. A clear separation of probiotic and control Minas Frescal cheese was obtained using 1H NMR spectra, demonstrating that the addition of probiotic culture altered the metabolic profile of Minas Frescal cheese. Overall, the findings suggested that the addition of probiotic culture promoted the proteolysis in the fresh cheeses, decreased the lipolysis, and altered the volatile compounds Furthermore, NMR spectroscopy coupled to chemometrics tools could be used to differentiate probiotic and conventional cheeses.

Journal of Dairy Science published new progress about Alcohols Role: ANT (Analyte), FFD (Food or Feed Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, HPLC of Formula: 110-42-9.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

dos Santos, Anai L. published the artcileAnalysis of the seasonal variation in chemical profile of Piper glabratum Kunth essential oils using GCxGC/qMS and their antioxidant and antifungal activities, Product Details of C11H22O2, the main research area is Piper essential oil antioxidant antifungal seasonal variation.

Piper glabratum is a plant native from South America, which has been little studied, despite its use in folk medicine. In this study, chem. composition, antioxidant and antifungal activities of essential oils (EOs) from leaves of P. glabratum were investigated. The influence of seasonality on its chem. composition was also evaluated. The chem. characterization was performed by twodimensional gas chromatog. coupled with quadrupole mass spectrometry (GC×GC/qMS). Altogether, 199 compounds were identified in the EOs and their composition varied during the seasonal cycle. The main compounds found were sesquiterpenes and their oxygenated analogs. EOs showed antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl-DPPH (from 28.1 to 33.4 μg mL-1) and β-carotene assays (from 57.4 to 66.4%), and inhibitory action against C. albicans. The oils provided expressive properties; however, the yield of EO from winter was not enough for activities assays, remarking the influence of the seasonality on the biol. activities of this plant.

Journal of the Brazilian Chemical Society published new progress about Fungicides. 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Product Details of C11H22O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Loupakis, Fotios published the artcileCK7 and consensus molecular subtypes as major prognosticators in V600EBRAF mutated metastatic colorectal cancer, HPLC of Formula: 110-42-9, the main research area is human metastatic colorectal cancer BRAF mutation CK prognosticator.

Background: V600EBRAF mutated metastatic colorectal cancer (mCRC) is a subtype (10%) with overall poor prognosis, but the clin. experience suggests a great heterogeneity in survival. It is still unexplored the real distribution of traditional and innovative biomarkers among V600EBRAF mutated mCRC and which is their role in the improvement of clin. prediction of survival outcomes. Methods: Data and tissue specimens from 155 V600EBRAF mutated mCRC patients treated at eight Italian Units of Oncol. were collected. Specimens were analyzed by means of immunohistochem. profiling performed on tissue microarrays. Primary endpoint was overall survival (OS). Results: CDX2 loss conferred worse OS (HR = 1.72, 95%CI 1.03-2.86, p = 0.036), as well as high CK7 expression (HR = 2.17, 95%CI 1.10-4.29, p = 0.026). According to Consensus Mol. Subtypes (CMS), CMS1 patients had better OS compared to CMS2-3/CMS4 (HR = 0.37, 95%CI 0.19-0.71, p = 0.003). Samples showing less TILs had worse OS (HR = 1.72, 95%CI 1.16-2.56, p = 0.007). Progression-free survival analyses led to similar results. At multivariate anal., CK7 and CMS subgrouping retained their significant correlation with OS. Conclusion: The present study provides new evidence on how several well-established biomarkers perform in a homogenousV600EBRAF mutated mCRC population, with important and independent information added to standard clin. prognosticators. These data could be useful to inform further translational research, for patients’ stratification in clin. trials and in routine clin. practice to better estimate patients’ prognosis.

British Journal of Cancer published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (CDX2). 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, HPLC of Formula: 110-42-9.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gou, Min published the artcileComprehensive investigation on free and glycosidically bound volatile compounds in Ziziphus jujube cv. Huizao, Product Details of C11H22O2, the main research area is Ziziphus jujube glycosidically bound volatile compound.

Both free and glycosidically bound volatile compounds of Ziziphus jujube cv. Huizao were comprehensively investigated in this study. There were 43 and 17 volatile compounds identified in free and bound fraction of ′′Huizao′′, resp. Green, sweet, floral, fruity, cream, sour/rancid and nut notes could describe the aroma profiles through quant. descriptive anal. In terms of free volatiles, 22 compounds with odor activity values ≥ 1 and 21 compounds with detection frequency ≥ 2. 3-Hydroxy-2-butanone, butane-2,3-dione, Me decanoate, Et decanoate, Me dodecanoate, 5-propyloxolan-2-one, 5-butyloxolan-2-one, 2-ethyl-3,5-dimethyl-pyrazine, (E)-but-2-enoic acid, hexanoic acid, hexanal, 6-methyl-5-hepten-2-one, 3-oxobutan-2-yl acetate, 5-ethyloxolan-2-one, and 3-methyl-butanoic acid were identified as key aroma-active compounds in ′′Huizao′′ via recombination and omission tests. Moreover, key aroma-active compounds of 3-hydroxy-2-butanone, 5-ethyloxolan-2-one, (E)-but-2-enoic acid, hexanoic acid and 3-methyl-butanoic acid were also detected in bound fraction, aroma intensity of ′′Huizao′′ could be effectively enhanced by enzymic hydrolysis.

Journal of Food Composition and Analysis published new progress about Alcohols Role: ANT (Analyte), FFD (Food or Feed Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 110-42-9 belongs to class esters-buliding-blocks, name is Methyl decanoate, and the molecular formula is C11H22O2, Product Details of C11H22O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics