Category: 110-38-3

Related Products of 110-38-3,Some common heterocyclic compound, 110-38-3, name is Ethyl caprate, molecular formula is C12H24O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 16 (PREPARATION OF DECANOL) A dry Schlenk tube under argon was charged with 51 mg (0.15 mmol) of dysprosium (III) isopropoxide. Triethoxysilane (1.4 mL, 7.5 mmol) and ethyl decanoate (696 muL, 3 mmol) were added and the reaction mixture was heated to 60 C. After 29 hours, GLC analysis of an aliquot taken from the reaction mixture showed 23% conversion. The reaction mixture was then heated to 70 C. After an additional 3 days, THF (8 mL) and aqueous NaOH (1 N, 15 mL) were added, and the mixture was stirred vigorously for 3 hours. The reaction was worked up as in Example 13. Purification by flash chromatography (ether:hexane=3:7) afforded 224 mg (47% yield) of decanol (>95% pure by 1 H-NMR analysis) and 40 mg of recovered starting material (84% pure, 5.5% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl caprate, its application will become more common.

Reference:
Patent; Massachusetts Institute of Technology; US5220020; (1993); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 110-38-3,Some common heterocyclic compound, 110-38-3, name is Ethyl caprate, molecular formula is C12H24O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 16 (PREPARATION OF DECANOL) A dry Schlenk tube under argon was charged with 51 mg (0.15 mmol) of dysprosium (III) isopropoxide. Triethoxysilane (1.4 mL, 7.5 mmol) and ethyl decanoate (696 muL, 3 mmol) were added and the reaction mixture was heated to 60 C. After 29 hours, GLC analysis of an aliquot taken from the reaction mixture showed 23% conversion. The reaction mixture was then heated to 70 C. After an additional 3 days, THF (8 mL) and aqueous NaOH (1 N, 15 mL) were added, and the mixture was stirred vigorously for 3 hours. The reaction was worked up as in Example 13. Purification by flash chromatography (ether:hexane=3:7) afforded 224 mg (47% yield) of decanol (>95% pure by 1 H-NMR analysis) and 40 mg of recovered starting material (84% pure, 5.5% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl caprate, its application will become more common.

Reference:
Patent; Massachusetts Institute of Technology; US5220020; (1993); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 110-38-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 110-38-3, name is Ethyl caprate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In a glove box in a nitrogen atmosphere, 3.33 mg of ruthenium complex 1c (0.005 mmol) Add to a 125-mL Parr autoclave, After adding 11.2 mg of potassium t-butoxide (0.1 mmol), Then take 2mL of tetrahydrofuran and add it to the kettle for a while. Finally, methyl benzoate (1.3615 g, 10 mmol) was added. After the autoclave is sealed, it is taken out of the glove box. Charge hydrogen to 50 atm. The mixture in the reaction kettle was heated and stirred in an oil bath at 120 C for 10 hours, The reactor was cooled to room temperature in a water bath and the remaining gas was slowly drained from the fume hood. Tridecane (50 muL) was added to the mixture as an internal standard, and the yield of methyl benzoate was determined by gas chromatography to be 99%.

The chemical industry reduces the impact on the environment during synthesis Ethyl caprate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Ding Kuiling; Qiu Jia; Yan Tao; Zhang Lei; Wang Zheng; (49 pag.)CN109553641; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics