Category: 103-26-4

Chary Devulapally, Yogananda published the artcileRhodium(III)-Catalyzed Dehydrogenative Annulation of 2-Arylindazoles with Cyclic Enones, SDS of cas: 103-26-4, the publication is European Journal of Organic Chemistry (2021), 2021(21), 3083-3090, database is CAplus.

An oxidative annulation of 2-arylindazoles with cyclic enones has was developed using Rh(III)/Cu(OAc)₂ catalytic system for the first time to produce 3,4-dihydroindazolo[2,3-f]phenanthridin-1(2H)-one derivatives in good yields with high selectivity. When AgSbF₆ was used instead of Cu(OAc)₂, the corresponding uncyclized products, 3-(2-(2H-indazol-2-yl)phenyl)cyclohexan-1-one scaffolds were formed exclusively. The reaction proceeds through a sequential conjugate addition of ortho-C-H bond of aryl group followed by an oxidative annulation of indazole ring to generate fused polycyclic scaffolds.

European Journal of Organic Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, SDS of cas: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Guosong published the artcileRegioselective Radical Borylation of α,β-Unsaturated Esters and Related Compounds by Visible Light Irradiation with an Organic Photocatalyst, Related Products of esters-buliding-blocks, the publication is Organic Letters (2021), 23(11), 4353-4357, database is CAplus and MEDLINE.

Radical hydroboration reactions have only recently been reported and are still rare. Here the authors describe a photoredox radical hydroboration of α,β-unsaturated esters, amides, ketones, and nitriles with NHC-boranes that uses only an organocatalyst and visible light. The conditions are mild, the substrate scope is broad, and the α/β regioselectivity is high. The reaction requires only the organocatalyst; there is no costly metal, and there are no other additives (base, cocatalyst, initiator).

Organic Letters published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhou, Hua-Jian published the artcileHydropyridylation of α,β-Unsaturated Esters through Electroreduction of 4-Cyanopyridine, Application of Methyl 3-phenyl-2-propenoate, the publication is Journal of Organic Chemistry (2022), 87(8), 5328-5338, database is CAplus and MEDLINE.

A mild and highly efficient method for the hydropyridylation of α,β-unsaturated esters has been developed. This protocol provides the products smoothly with a wide substrate scope in an undivided cell under ambient conditions. Moreover, studies showed that the scope could be extended to other unsaturated compounds, including enones and aldehydes.

Journal of Organic Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C23H20BN, Application of Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kurabayashi, Hideaki published the artcileThe Mizoroki-Heck reaction in mesoionic 1-butyl-3-methyltetrazolium-5-olate, Category: esters-buliding-blocks, the publication is Tetrahedron (2021), 132450, database is CAplus.

The 1-butyl-3-methyltetrazolium-5-olate, a mesoionic compound, exists as a liquid at room temperature and can be used as a polar solvent for the Mizoroki-Heck reaction, wherein it has been proven to be a superior solvent to other solvents. The reaction of iodobenzene with Et acrylate in the presence of palladium acetate in mesoionic liquid 1-butyl-3-methyltetrazolium-5-olate at 40°C for 24 h gave Et cinnamate in 78% yield in the absence of ligands, while the use of other solvents, such as [bmim][BF₄], [bmim][PF₆], and DMF gave lower yields (43%, 37%, and 17%, resp.) under the same conditions. Heck-type coupling reactions of electron-deficient or electron-rich aryl iodides RC₆H₄I (R = H, 2-Me, 3-NO₂, 4-OMe, etc.) and bromobenzene with olefins such as Et acrylate, styrene, acrylonitrile, etc. (15 examples, 7%-97%) were performed in 1-butyl-3-methyltetrazolium-5-olate. When a phosphine ligand was added to the reaction mixture, aryl bromides could be used, and the mesoionic liquid containing the catalysts could be reused at least five times.

Tetrahedron published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Xiang-Gui published the artcileCobalt-catalyzed Divergent Markovnikov and Anti-Markovnikov Hydroamination, Synthetic Route of 103-26-4, the publication is Organic Letters (2022), 24(1), 22-26, database is CAplus and MEDLINE.

Catalytic hydroamination of the readily available alkenes is among the most straightforward means to construct diverse alkyl amines. To this end, the facile access to both regioselectivity, i.e., Markovnikov or anti-Markovnikov hydroamination, with min. reaction-parameter alternation, remains challenging. Herein, authors report a cobalt-catalyzed highly selective and divergent Markovnikov and anti-Markovnikov hydroamination of alkenes, in which the switch of regioselectivity is achieved simply by the variation of the addition sequence of 9-BBN.

Organic Letters published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C12H9N3O4, Synthetic Route of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kawamata, Yu published the artcileChemoselective Electrosynthesis Using Rapid Alternating Polarity, HPLC of Formula: 103-26-4, the publication is Journal of the American Chemical Society (2021), 143(40), 16580-16588, database is CAplus and MEDLINE.

Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochem. offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using d.c. (DC). In contrast, applying a.c. (AC) has been known to change reaction outcomes considerably on an anal. scale but has rarely been strategically exploited for use in complex preparative organic synthesis. Here we show how a square waveform employed to deliver elec. current-rapid alternating polarity (rAP)-enables control over reaction outcomes in the chemoselective reduction of carbonyl compounds, one of the most widely used reaction manifolds. The reactivity observed cannot be recapitulated using DC electrolysis or chem. reagents. The synthetic value brought by this new method for controlling chemoselectivity is vividly demonstrated in the context of classical reactivity problems such as chiral auxiliary removal and cutting-edge medicinal chem. topics such as the synthesis of PROTACs.

Journal of the American Chemical Society published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rosnizam, Arif Naim published the artcilePalladium(II) complexes bearing N,O-bidentate Schiff base ligands: Experimental, in-silico, antibacterial, and catalytic properties, Category: esters-buliding-blocks, the publication is Journal of Molecular Structure (2022), 132821, database is CAplus.

Two N,O-bidentate ligands (1, 2), and their Pd(II) complexes, (1a, 2a) were synthesized and characterized via elemental anal., IR, ¹H and ¹³C NMR, magnetic moment and UV-Visible spectroscopy. Single crystal x-ray diffraction revealed that 1a crystallized as a monoclinic system in P2(1)/c space group, where two ligand 1 moieties coordinate to one palladium(II) center through imine N and phenolic O donor atoms in a bis-bidentate manner, manifesting in a square planar geometry. The exptl. spectral data of 1 and 1a were in good agreement with the calculated ones obtained in gas phase and polarizable continuum model (PCM) at the B3LYP/LANL2DZ level of theory. The exptl. spectroscopic and Z-matrix data were also well reproduced with high correlation coefficients The intercontact between 1a complex units was determined through Hirshfeld surface anal. and electrostatic potentials (ESP) maps, showing that the most predominant interactions were H^…H (53.4%), C^…H (25.3%) and O^…H (12.6%). 1 And 1a were screened in-vitro to evaluate their antibacterial activity against two Gram-pos. (S. aureus, S. haemolyticus) and two Gram-neg. (P. aeruginosa, S. sonnei) bacteria. The antibacterial results revealed that 1a exhibited slight activity against Gram-neg. bacteria, while the free ligand displayed no activity. The catalytic efficiency of 1a and 2a was evaluated in Mizoroki-Heck reaction of iodobenzene and Me acrylate, and Suzuki-Miyaura reaction of iodobenzene and phenylboronic acid. Both catalysts resulted in good conversion percentages with 1a showing a more superior performance.

Journal of Molecular Structure published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Haifei published the artcileAg(I)/CAAA-Amidphos Complex Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Acrylates for the Formal Synthesis of (+)-Ibophyllidine, HPLC of Formula: 103-26-4, the publication is Synlett (2021), 32(14), 1437-1446, database is CAplus.

In this work, the authors introduced a multifunctional Ag(I)/CAAA-amidphos complex catalyzed asym. 1,3-dipolar cycloaddition of acrylates with α-imino esters, affording a series of 2,4,5-trisubstituted endo-pyrrolidines, e.g., I, in good yields (up to 97%) with high enantioselectivities (up to 98% ee). Meanwhile, the catalytic system was also applied in the three-component one-pot reaction of α-imino esters formed in situ under the action of N,N’-diisopropylcarbodiimide. In addition, the gram-scale reaction was realized for the formal synthesis of (+)-ibophyllidine (II) in eight steps.

Synlett published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C6H3ClIN3, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Askey, Hannah E. published the artcilePhotocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is Journal of the American Chemical Society (2021), 143(39), 15936-15945, database is CAplus and MEDLINE.

A solution to these problems using organophotoredox catalysis, enabling a direct, modular and sustainable preparation of α-(di)substituted γ-arylamines, including challenging electron-neutral and moderately electron-rich aryl groups was reported. A broad range of functionalities were tolerated, and the reactions was run on multigram scale in continuous flow. The method was applied to a concise, protecting-group-free synthesis of the blockbuster drug Fingolimod, as well as a phosphonate mimic of its in-vivo active form (by iterative α-C-H functionalization of ethanolamine). The reaction was sequenced with an intramol. N-arylation to provided a general and modular access to valuable (spirocyclic) 1,2,3,4-tetrahydroquinolines and 1,2,3,4-tetrahydronaphthyridines. Mechanistic and kinetic studies supportes an irreversible hydrogen atom transfer activation of the alkylamine by the azidyl radical and some contribution from a radical chain. The reaction was photon-limited and exhibits a zero-order dependence on amine, azide, and photocatalyst, with a first-order dependence on styrene.

Journal of the American Chemical Society published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Garnes-Portoles, Francisco published the artcileRegioirregular and catalytic Mizoroki-Heck reactions, Related Products of esters-buliding-blocks, the publication is Nature Catalysis (2021), 4(4), 293-303, database is CAplus.

Here, the ligand-free, few-atom palladium clusters in solution catalyze the α-selective intramol. Mizoroki-Heck coupling of iodoaryl cinnamates, and mechanistic studies support the formation of a sterically encumbered cinnamate-palladium cluster intermediate was showed. Following this rationale, the α-selective intermol. coupling of aryl iodides with styrenes was also achieved with palladium clusters encapsulated within fine-tuned and sterically restricted zeolite cavities to produce 1,1-bisarylethylenes, which are further engaged with aryl halides by a metal-free photoredox-catalyzed coupling. These ligand-free methodologies significantly expand the chem. space of the Mizoroki-Heck coupling.

Nature Catalysis published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics