Category: 103-25-3

An article Engaging alpha-Fluorocarboxylic Acids Directly in Decarboxylative C-C Bond Formation WOS:000526395000048 published article about POSITRON-EMISSION-TOMOGRAPHY; CARBOXYLIC-ACIDS; MERGING PHOTOREDOX; H BONDS; FLUORINE; NICKEL; DEOXYFLUORINATION; CARBOFLUORINATION; CATALYSIS; DERIVATIVES in [Wang, Hongyu; Liu, Chen-Fei; Ho, Yee Ann; Koh, Ming Joo] Natl Univ Singapore, Dept Chem, Singapore 117549, Singapore; [Song, Zhihui; Yuan, Mingbin; Gutierrez, Osvaldo] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA in 2020.0, Cited 86.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3. Product Details of 103-25-3

Fluorine-containing organic molecules, particularly those that bear (sp(3))C-F bonds, are rapidly gaining prominence in modern chemical synthesis. Although extensive studies have been devoted to the preparation of secondary and tertiary fluorides, crucial shortcomings remain: for example, lengthy substrate synthesis, contrived installation of difficult-to-remove directing/activating units, excessive waste generation and/or limited functional group compatibility. Here, we show that readily accessible alpha-onofluoro carboxylic acids, which are conventionally difficult substrates for cross-coupling, undergo direct decarboxylative crosscoupling with sp(2-) and sp(3-)hybridized organohalides to afford a wide assortment of fluorinated products. Reactions are typically promoted by a combination of 1 mol % of an Ir-based photocatalyst and 2-15 mol % of a bipyridine-Ni complex, delivering products in up to 86% yield under blue LED light irradiation. Concise synthesis of key therapeutic candidates underscores utility, complementarity, and distinct advantages compared with existing methods. DFT calculations are used to rationalize the distinct reactivity of alpha-fluoro carboxylic acid substrates (vs nonfluorinated parent acids) under decarboxylation conditions.

About Methyl 3-phenylpropionate, If you have any questions, you can contact Wang, HY; Liu, CF; Song, ZH; Yuan, MB; Ho, YA; Gutierrez, O; Koh, MJ or concate me.. Product Details of 103-25-3

Reference:
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An article Aldehydes as potential acylating reagents for oxidative esterification by inorganic ligand-supported iron catalysis WOS:000480643800027 published article about AEROBIC OXIDATION; BUILDING-BLOCKS; ALCOHOLS; ESTERS; TRANSFORMATION; CONVERSION; COMPLEXES; HEME in [Yu, Han; Wei, Yongge] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Minist Educ, Beijing 100084, Peoples R China; [Yu, Han; Wang, Jingjing; Wu, Zhikang; Zhao, Qixin; Dan, Demin; Han, Sheng] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China; [Tang, Jiangjiang] Northwest A&F Univ, Coll Sci, Shaanxi Engn Ctr Bioresource Chem & Sustainable U, Yangling 712100, Shaanxi, Peoples R China; [Wei, Yongge] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China in 2019.0, Cited 48.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3. Formula: C10H12O2

The oxidative esterification of various aldehydes with alcohols could be achieved by a heterogeneous iron(iii) catalyst supported on a ring-like POM inorganic ligand under mild conditions, affording the corresponding esters, including several drug molecules and natural products, in high yields. ESI-MS and control experiments demonstrated that POM-Fe-V(O) was the active catalytic species and the plausible mechanism was presented. More importantly, the 6th run of the iron catalyst recycles shows only a slight decrease in the yield.

About Methyl 3-phenylpropionate, If you have any questions, you can contact Yu, H; Wang, JJ; Wu, ZK; Zhao, QX; Dan, DM; Han, S; Tang, JJ; Wei, YG or concate me.. Formula: C10H12O2

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
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In 2020.0 EUR J ORG CHEM published article about OXIDATIVE COUPLING REACTION; FACILE SYNTHESIS; C-H; COPPER; AMINOOXYGENATION; DIAMINATION; ANALOGS; KETONES; ACTIVATION; ANNULATION in [Liu, Zhen; Shi, Min] East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Meilong Rd 130, Shanghai 200237, Peoples R China; [Liu, Zhen; Shi, Min] East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Meilong Rd 130, Shanghai 200237, Peoples R China; [Zhang, Yan-Shun; Wei, Yin; Shi, Min] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Chinese Acad Sci,Ctr Excellence Mol Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2020.0, Cited 41.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3. Safety of Methyl 3-phenylpropionate

Polysubstituted imidazolinones were synthesized in a facile metal-free cascade nucleophilic cyclization of easily available amidines and 2-substituted acrylates. This protocol is distinguished by simple, mild, and catalyst-free reaction conditions with a broad substrate scope, affording the desired products in moderate to good yields and providing an efficient strategy for synthesis of polysubstituted imidazolinone.

Safety of Methyl 3-phenylpropionate. About Methyl 3-phenylpropionate, If you have any questions, you can contact Liu, Z; Zhang, YS; Wei, Y; Shi, M or concate me.

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Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recently I am researching about CARBOXYLIC-ACIDS; REDUCTION; EFFICIENT; CARBONYL; HYDROSILYLATION; HYDROGENATION; HYDROBORATION; COMPLEXES; LIGAND; MILD, Saw an article supported by the SERB New DelhiDepartment of Science & Technology (India)Science Engineering Research Board (SERB), India [EMR/2016/002517]; Department of Atomic EnergyDepartment of Atomic Energy (DAE); NISER; CSIRCouncil of Scientific & Industrial Research (CSIR) – India. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Pattanaik, S; Chidambaram, G. The CAS is 103-25-3. Through research, I have a further understanding and discovery of Methyl 3-phenylpropionate. Quality Control of Methyl 3-phenylpropionate

Efficient and selective reduction of esters to aldehydes and alcohols is reported in which a simple cobalt pincer catalyst catalyses both transformations using diethylsilane as a reductant. Remarkably, the reaction selectivity is controlled by the stoichiometry of diethylsilane.

Quality Control of Methyl 3-phenylpropionate. About Methyl 3-phenylpropionate, If you have any questions, you can contact Pattanaik, S; Chidambaram, G or concate me.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
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Recently I am researching about COPPER-MEDIATED DIFLUOROMETHYLATION; ARYL BORONIC ACIDS; NUCLEOPHILIC DIFLUOROMETHYLATION; STEREOSELECTIVE-SYNTHESIS; PALLADIUM COMPLEXES; ALPHA-ARYLATION; ALKENES; FLUORINE; METHOXYCARBONYLATION; ALKOXYCARBONYLATION, Saw an article supported by the State of Mecklenburg-Vorpommern; Chinese Scholarship Council (CSC)China Scholarship Council. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Liu, JW; Yang, J; Ferretti, F; Jackstell, R; Beller, M. The CAS is 103-25-3. Through research, I have a further understanding and discovery of Methyl 3-phenylpropionate. SDS of cas: 103-25-3

The first catalyst for the alkoxycarbonylation of gem-difluoroalkenes is described. This novel catalytic transformation proceeds in the presence of Pd(acac)(2)/1,2-bis((di-tert-butylphosphan-yl)methyl)benzene (btbpx) (L4) and allows for an efficient and straightforward access to a range of difluoromethylated esters in high yields and regioselectivities. The synthetic utility of the protocol is showcased in the practical synthesis of a Cyclandelate analogue using this methodology as the key step.

SDS of cas: 103-25-3. About Methyl 3-phenylpropionate, If you have any questions, you can contact Liu, JW; Yang, J; Ferretti, F; Jackstell, R; Beller, M or concate me.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, C; Wu, WQ; Lu, H; Yu, TY; Xu, WH; Wei, H in [Jiang, Cheng; Wu, Wen-Qiang; Lu, Hong; Yu, Tian-Yang; Xu, Wen-Hua; Wei, Hao] Northwest Univ, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710127, Shaanxi, Peoples R China published Rhodium-Catalyzed Hiyama Coupling Reaction of Unstrained Ketones via C-C Bond Cleavage in 2019.0, Cited 41.0. Name: Methyl 3-phenylpropionate. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3.

A Rh-III-catalyzed Hiyama cross-coupling reaction has been successfully developed. Cleavage of the less polar C-C bond provides an efficient strategy to enable ketones to be as electrophilic reagents, and the corresponding substituted indoles with diverse functional groups are efficiently synthesized in good to high yields.

About Methyl 3-phenylpropionate, If you have any questions, you can contact Jiang, C; Wu, WQ; Lu, H; Yu, TY; Xu, WH; Wei, H or concate me.. Name: Methyl 3-phenylpropionate

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 103-25-3. In 2020.0 CHEM SCI published article about REGIOSELECTIVE SYNTHESIS; 4+2 CYCLOADDITION; SUBSTITUTED NAPHTHALENES; CATALYZED BENZANNULATION; O-ALKYNYLBENZALDEHYDES; RING TRANSFORMATION; DERIVATIVES; YNAMIDES; VERSATILE; ANNULATION in [Wu, An; Qian, Hui; Zhao, Wanxiang; Sun, Jianwei] Hong Kong Univ Sci & Technol HKUST, Dept Chem, Kowloon, Clear Water Bay, Hong Kong, Peoples R China; [Wu, An; Qian, Hui; Zhao, Wanxiang; Sun, Jianwei] HKUST Shenzhen Res Inst, 9 Yuexing 1st Rd,Hitech Pk, Shenzhen 518057, Peoples R China in 2020.0, Cited 62.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3.

Described here is a modular strategy for the rapid synthesis of beta-functionalized electron-rich naphthalenes, a family of valuable molecules lacking general access previously. Our approach employs an intermolecular benzannulation ofin situgenerated isobenzopyrylium ions with various electron-rich alkynes, which were not well utilized for this type of reaction before. These reactions not only feature a broad scope, complete regioselectivity, and mild conditions, but also exhibit unusual product divergence depending on the substrate substitution pattern. This divergence allows further expansion of the product diversity. Control experiments provided preliminary insights into the reaction mechanism.

Product Details of 103-25-3. About Methyl 3-phenylpropionate, If you have any questions, you can contact Wu, A; Qian, H; Zhao, WX; Sun, JW or concate me.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: C10H12O2. In 2020.0 MOL CATAL published article about PALLADIUM COMPLEXES; DIRECT CARBONYLATION; METHOXYCARBONYLATION; LIGANDS; HYDROESTERIFICATION; STYRENE; EFFICIENT; DIPHOSPHINES; MECHANISM; OLEFINS in [Liang, Wen-Yu; Liu, Lei; Zhou, Qing; Yang, Da; Lu, Yong; Liu, Ye] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China in 2020.0, Cited 33.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3.

The Pd-catalyzed alkoxycarbonylation of alkenes using water as a promoter has been scarcely reported before. Herein, water instead of Bronsted/Lewis acid was found to effectively improve the catalytic performance of Pd (MeCN)(2)Cl-2-Xantphos system for alkoxycarbonylation of alkenes. Under the optimal conditions, the best yield of 97% was obtained for the target products (methyl 3-phenylpropanoate and methyl 2-phenylpropanoate) with L/B of 4.3 and TON of 192. With the involvement of water, Pd(MeCN)(2)Cl-2-Xantphos system also exhibited the moderate to good generality to alkoxycarbonylation of different kinds of alkenes with alcohols. The in situ high pressure FT-IR analysis verified that water played an important role in promoting formation and stability of Pd-H active species which was responsible for the efficient alkoxycarbonylation of alkenes. In addition, the ligand effect of Xantphos on this reaction was discussed.

HPLC of Formula: C10H12O2. About Methyl 3-phenylpropionate, If you have any questions, you can contact Liang, WY; Liu, L; Zhou, Q; Yang, D; Lu, Y; Liu, Y or concate me.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

I found the field of Cardiovascular System & Cardiology very interesting. Saw the article Heart failure progression and mortality in atrial fibrillation patients with preserved or reduced left ventricular ejection fraction published in 2019.0. Recommanded Product: 103-25-3, Reprint Addresses Saksena, S (corresponding author), Electrophysiol Res Fdn, 161 Washington Valley Rd,Suite 201, Warren, NJ 07059 USA.; Saksena, S (corresponding author), Rutgers Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA.. The CAS is 103-25-3. Through research, I have a further understanding and discovery of Methyl 3-phenylpropionate

Background Atrial fibrillation (AF) worsens cardiovascular (CV) outcomes of heart failure (HF) and vice versa. The impact of rate or rhythm control strategies on HF progression and survival remains unclear. Methods We examined the risk of HF progression in AF patients (pts) with a prior HF event and minimal or no HF burden (NYHA class 0 or 1). They were stratified into HF with a preserved left ventricular ejection fraction (>= 40%, pEF) or reduced EF (< 40%, rEF). HF subgroups from the Rate and Rhythm arm were compared for the primary outcome of worsening HF or death (WHFD), total mortality, cardiovascular mortality, and cardiovascular hospitalizations. Results Four hundred ninety-two AF pts (HFpEF = 349, HFrEF = 143) were analyzed. Baseline characteristics were generally comparable in the Rate and Rhythm arms of the two subgroups. Over a median follow-up of 4 years, HF recurred and worsened in 66.6% and 41.2% of pts by >= 1 and >= 2 NYHA classes, respectively. HF progression by even 1 NYHA class increased the mortality risk in HFpEF (hazard ratio (HR) 2.06; 95% confidence intervals (CI) 1.25-3.4; p = 0.004) and HFrEF (HR 1.9; 95% CI 0.99-3.66; p = 0.054). Cardiovascular hospitalization (CVH) increased in HFpEF (HR 3.67; 95% CI 2.56, 5.25; p < 0.0001) and HFrEF (HR 2.8; 95% CI 1.53-5.14; p = 0.0009). HF progression by 2 or more NYHA classes or death was significantly worse in pts with HFrEF with the Rate control strategy compared with the Rhythm control (HR 1.62; 95% CI 1.03-2.53; p = 0.036) but similar in pts with HFpEF (HR 0.88; 95% CI 0.64-1.21; p = 0.440).The time to first AF recurrence was longer in the Rhythm arms of both HF subgroups as compared with Rate (Figure, p < 0.05). Conclusions (1) HF progression in AF pts with a prior HF event confers significant mortality and CVH risk in both HFrEF and HFpEF populations. (2) HF progression is more pronounced with a Rate control strategy in AF pts with HFrEF, but is comparable to Rhythm control in AF pts with HFpEF. (3) A Rhythm control strategy may be desirable to reduce HF progression in pts with HFrEF and AF. Prospective clinical trials appear warranted to examine HF progression by treatment strategy in HFpEF and HFrEF populations with AF. Recommanded Product: 103-25-3. About Methyl 3-phenylpropionate, If you have any questions, you can contact Slee, A; Saad, M; Saksena, S or concate me.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: Methyl 3-phenylpropionate. Wang, Z; Zhao, ZW; Li, Y; Zhong, YX; Zhang, QY; Liu, QB; Solan, GA; Ma, YP; Sun, WH in [Wang, Zheng; Zhao, Ziwei; Li, Yong; Liu, Qingbin] Hebei Normal Univ, Coll Chem & Mat Sci, Hebei Key Lab Organ Funct Mol, Shijiazhuang 050024, Hebei, Peoples R China; [Wang, Zheng; Zhang, Qiuyue; Solan, Gregory A.; Ma, Yanping; Sun, Wen-Hua] Chinese Acad Sci, Inst Chem, Key Lab Engn Plast, Beijing 100190, Peoples R China; [Wang, Zheng; Zhang, Qiuyue; Solan, Gregory A.; Ma, Yanping; Sun, Wen-Hua] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China; [Wang, Zheng] Agr Univ Hebei, Coll Sci, Baoding 071001, Peoples R China; [Zhong, Yanxia] Shijiazhuang Med Coll, Dept Nursing, Shijiazhuang 050000, Hebei, Peoples R China; [Solan, Gregory A.] Univ Leicester, Dept Chem, Univ Rd, Leicester LE1 7RH, Leics, England published Ruthenium-catalyzed hydrogenation of CO(2)as a route to methyl esters for use as biofuels or fine chemicals in 2020.0, Cited 83.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3.

A novel robust diphosphine-ruthenium(ii) complex has been developed that can efficiently catalyze both the hydrogenation of CO(2)to methanol and itsin situcondensation with carboxylic acids to form methyl esters; a TON of up to 3260 is achievable for the CO(2)to methanol step. Both aromatic and aliphatic carboxylic acids can be transformed to their corresponding methyl esters with high conversion and selectivity (17 aliphatic and 18 aromatic examples). On the basis of a series of experiments, a mechanism has been proposed to account for the various steps involved in the catalytic pathway. More importantly, this approach provides a promising route for using CO(2)as a C1 source for the production of biofuels, fine chemicals and methanol.

Recommanded Product: Methyl 3-phenylpropionate. About Methyl 3-phenylpropionate, If you have any questions, you can contact Wang, Z; Zhao, ZW; Li, Y; Zhong, YX; Zhang, QY; Liu, QB; Solan, GA; Ma, YP; Sun, WH or concate me.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics