Author: Jessica.F

Essential Oils from Different Myrtaceae Species from Brazilian Atlantic Forest Biome – Chemical Dereplication and Evaluation of Antitrypanosomal Activity was written by Silva Maiolini, Tatiane Cristina;Rosa, Welton;de Oliveira Miranda, Daniel;Costa-Silva, Thais A.;Tempone, Andre G.;Pires Bueno, Paula Carolina;Ferreira Dias, Danielle;Aparecida Chagas de Paula, Daniela;Sartorelli, Patricia;Lago, Joao Henrique G.;Gomes Soares, Marisi. And the article was included in Chemistry & Biodiversity in 2022.Recommanded Product: (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate This article mentions the following:

Chagas Disease (CD), caused by flagellate protozoan Trypanosoma cruzi, is a Neglected Tropical Diseases (NTD) that affect approx. seven million people worldwide with a restrict therapeutical arsenal. In the present study, the essential oils from 18 Myrtaceae species were extracted, chem. dereplicated, and evaluated in vitro against T. cruzi. From these, eight essential oils were considered promising (IC50<10 娓璯/mL and SI>10) against the protozoan: Eugenia florida, E. acutata, E. widgrenii, Calyptranthes brasilienses, C. widgreniana, Plinia cauliflora, Campomanesia xanthocarpa, and Psidium guajava. Multivariate data anal. pointed out (E)-caryophyllene, 浼?humulene, limonene, caryophyllene oxide, and 浼?copaene playing an important role in the anti-T. cruzi activity. The obtained results demonstrated the potential of essential oils of Myrtaceae species as valuable sources of bioactive compounds against T. cruzi. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Recommanded Product: (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of fermentation temperature on volatile compounds of Petit Verdot red wines from the Spanish region of La Mancha (central-southeastern Spain) was written by Izquierdo-Canas, P. M.;Gonzalez Vinas, M. A.;Mena-Morales, A.;Perez Navarro, J.;Garcia-Romero, E.;Marchante-Cuevas, L.;Gomez-Alonso, S.;Sanchez-Palomo, E.. And the article was included in European Food Research and Technology in 2020.Application of 695-06-7 This article mentions the following:

The aim of this work was to research the relationship between volatile composition of Petit Verdot red wines and the fermentation temperature Winemaking process was carried out at 17鎺矯, 21鎺矯, and 25鎺矯 temperatures Solid-phase extraction (SPE) and gas chromatog.-mass spectrometry (GC-MS) were used to analyze volatile compounds The odor activity values (OAVs) from the different compounds were classified into seven odorant series that describe the aroma profile (fruity, floral, green/fresh, sweet, spicy, fatty, and other odours). The value of each aromatic series was obtained by adding the OAVs of the volatile compounds to each series. The volatile composition was significantly affected by the temperature of the fermentation In general, the increase in the fermentation temperature of La Mancha Petit Verdot red wines from 17 to 25鎺矯 produced an increase in the concentration of volatile aroma compounds The highest aroma contributions to Petit Verdot wine were fruity, sweet and floral series, followed by fatty and spicy series, regardless of fermentation temperature The highest values of aromatic series were found in wines fermented at 21鎺矯. The results of this work show that changes in the fermentation temperature of wines can have a significant impact on their volatile compound profile. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Application of 695-06-7).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 695-06-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of Solvent on the Mechanical and Structural Properties of N-Alkyldiamide Organogels was written by Khacef, Leila;Legros, Philippe;Herve, Pascal;Ovarlez, Guillaume;Medina-Gonzalez, Yaocihuatl. And the article was included in Langmuir in 2021.Quality Control of Ethyl 2-hydroxybenzoate This article mentions the following:

Here, we study organogels prepared thanks to a new organogelator, the N-oleyldiamide mol., which shows a remarkable propensity to gelify a large scope of solvents, from aprotic to high protic solvents. The solvent plays a key role in the formation and stability of supramol. self-assemblies. However, the understanding and the control of its effects can be complex as many parameters are a priori involved. This study aims to understand the effect of solvent on the structures of organogels and on their final mech. properties. Five solvent classes have been selected ranking from low protic to high protic, according to the Hansen H-bond parameter 鏈猦. The solvent proticity appears to be one of the main parameters that affect the organogel internal structure and therefore the final rheol. properties. For a given organogelator fraction, the terminal elastic modulus measured by oscillatory rheol. is observed to increase significantly with the Hansen H-bond solvent parameter 鏈猦. Materials of different mech. properties are then shown to display various structures, which are investigated thanks to cryo-SEM. Besides, wide-angle X-ray scattering (WAXS) has been used to probe the gelator organization at the mol. scale with regard to the solvent nature, to understand the supramol. self-assembly of this promising mol. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Quality Control of Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Ethyl 2-hydroxybenzoate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Initial studies on the synthesis of the antitumor agent CC-1065. 3,4-Disubstituted pyrroles and 3,3′-bipyrroles was written by Magnus, Philip;Or, Yat Sun. And the article was included in Journal of the Chemical Society, Chemical Communications in 1983.Computed Properties of C8H11NO2 This article mentions the following:

Et sorbate with 4-MeC₆H₄SO₂CH₂NC (I) and NaH in Me₂SO-Et₂O at 20鎺?for 3 h gave 80% 3,4-disubstituted pyrrole II (R = H) (III). The sulfone II (R = SO₂Ph), prepared from III in 90% yield, was treated with I, HN(SiMe₃)₂, and NaH in THF at O鎺?for 10 min to give 85% 3,3′-bipyrrole IV (R¹ = H). II (R = SO₂Ph) with 4-MeC₆H₄SO₂CH(NC)CH₂CH:CH₂ gave the 3,3′-bipyrrole IV (R¹ = allyl). In the experiment, the researchers used many compounds, for example, Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7Computed Properties of C8H11NO2).

Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C8H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Assessment of phenolic and volatile compounds of commercial Sacha inchi oils and sensory evaluation was written by Ramos-Escudero, Fernando;Morales, Maria Teresa;Ramos Escudero, Monica;Munoz, Ana Maria;Cancino Chavez, Keidy;Asuero, Agustin G.. And the article was included in Food Research International in 2021.Name: 5-Ethyldihydrofuran-2(3H)-one This article mentions the following:

Sacha inchi is a super seed primarily grown in the Amazon rainforest of Peru. One of the main products obtained from seeds is oil. This product is rich in polyunsaturated fatty acids, tocopherols, and sterols. The objective of this work was to authenticity evaluate of the Sacha inchi oil by means of characterization of phenols, volatile compounds, and sensory profile. The phenolic and volatile compounds were analyzed using liquid chromatog.-electrospray ionization-time of flight/mass spectrometry (HPLC-ESI-TOF/MS) and headspace solid phase microextraction combined with gas chromatog. and mass spectrometry (HS-SPME/GC-MS), resp. A total of 16 phenolic compounds were detected in com. Sacha inchi oils, while 54 compounds have been found in the volatile fraction. These compounds mainly correspond to notes generated by alcs., aldehydes, acids, ketones, and terpenoids. Principal component anal. (PCA) showed that the first two PCs account for 71.13% of total variance. Statistical anal. was used to observe the relationships between phenolic and volatile compounds; therefore, consequently, it has been found that 16 volatile compounds may have a significant influence upon overall perceived flavor and odor of the com. Sacha inchi oils. According to the odor and flavor, the Sacha inchi oil is characterized by “green” odor notes, seed, dried fruit and rough. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Name: 5-Ethyldihydrofuran-2(3H)-one).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Name: 5-Ethyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold was written by Nguyen, T. Vu;Minrovic, Bradley M.;Melander, Roberta J.;Melander, Christian. And the article was included in ChemMedChem in 2019.Reference of 87694-53-9 This article mentions the following:

Tuberculosis (TB) remains a significant global health problem for which new therapeutic options are sorely needed. The ability of the causative agent, Mycobacterium tuberculosis, to reside within host macrophages and form biofilm-like communities contributes to the persistent and drug-tolerant nature of the disease. Compounds that can prevent or reverse the biofilm-like phenotype have the potential to serve alongside TB antibiotics to overcome this tolerance, and decrease treatment duration. Using Mycobacterium smegmatis as a surrogate organism, the authors report the identification of two new 2-aminoimidazole compounds that inhibit and disperse mycobacterial biofilms, work synergistically with isoniazid and rifampicin to eradicate preformed M. smegmatis biofilms in vitro, are nontoxic toward Galleria mellonella, and exhibit stability in mouse plasma. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Reference of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anodic oxidation potentials of substituted pyrroles: derivation and analysis of substituent partial potentials was written by Tabba, Hani D.;Smith, Kevin M.. And the article was included in Journal of Organic Chemistry in 1984.Application In Synthesis of Ethyl 4-methyl-1H-pyrrole-3-carboxylate This article mentions the following:

The anodic oxidation potentials of 117 pyrroles, determined by cyclic voltammetry, were used to estimate substituent partial potentials; the substituent constants accurately predicted the oxidation potentials of any common substituted pyrrole. Calculated and observed oxidation potentials differed when 2 strongly electron-withdrawing substituents (EWS) were located at C(2) and C(5) and when the pyrrole was unsubstituted at C(2) and had a strong EWS at C(5). LFER of the substituent partial potentials with 锜?sub>p and 锜?sub>m were not good; a good LFER of substituent partial potentials and the pK_a of 5-pyrrolecarboxylic acids was observed In the experiment, the researchers used many compounds, for example, Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7Application In Synthesis of Ethyl 4-methyl-1H-pyrrole-3-carboxylate).

Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Application In Synthesis of Ethyl 4-methyl-1H-pyrrole-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characterization of odor-active volatiles and odor contribution based on binary interaction effects in mango and vodka cocktail was written by Niu, Yunwei;Wang, Pinpin;Xiao, Qing;Xiao, Zuobing;Mao, Haifang;Zhang, Jun. And the article was included in Molecules in 2020.Quality Control of Methyl2-methylbutyrate This article mentions the following:

Thirty-six volatile compounds, composed of 18 esters, 10 terpenes, and 8 others, were detected by headspace-solid phase microextraction (HS-SPME) equipped with gas chromatog.-mass spectrometry (GC-MS) in mango and vodka cocktail. Moreover, these compounds were detected by olfactometry using aroma intensities. Comparing these compounds revealed that the aroma intensities (AIs) of limonene, 3-carene, myrcene, 灏?caryophyllene, and citronellyl propanoate were higher than others (AIs 閳?4). In this context, limonene was selected as the reference compound on the basis of the strongest component model. The aim of this study was to determine the perceptual interaction between limonene and 3-carene, myrcene, 灏?caryophyllene, citronellyl propanoate, resp., in a binary mixture In addition, feller’s addition model revealed that limonene presented an addition effect when combined with 3-carene, myrcene, 灏?caryophyllene, and citronellyl propanoate. It could be stated that these compounds played an important role in the aroma of mango and vodka cocktail. The results demonstrated that mol. structure and the ratio between compounds affected the synergistic effect, and compounds with similar structure and aroma were more prone to undergo addition and synergy. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Quality Control of Methyl2-methylbutyrate).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of Methyl2-methylbutyrate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts was written by Brnardic, Edward J.;Fraley, Mark E.;Garbaccio, Robert M.;Layton, Mark E.;Sanders, John M.;Culberson, Chris;Jacobson, Marlene A.;Magliaro, Brian C.;Hutson, Pete H.;O’Brien, Julie A.;Huszar, Sarah L.;Uslaner, Jason M.;Fillgrove, Kerry L.;Tang, Cuyue;Kuo, Yuhsin;Sur, Sylvie M.;Hartman, George D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Recommanded Product: 16413-26-6 This article mentions the following:

Hit to lead optimization of (5R)-5-hexyl-3-phenyl-1,3-oxazolidin-2-one as a pos. allosteric modulator of mGluR2 is described. Improvements in potency and metabolic stability were achieved through SAR on both ends of the oxazolidinone. The optimized lead compound 34 (I) was found to be brain penetrant and active in a rat ketamine-induced hyperlocomotion model for antipsychotic activity. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An efficient protocol for multicomponent synthesis of 1H-chromeno[4,3-b]pyridin-5(4H)-ones derivatives was written by Chen, Zhiwei;Gu, Jinying;Su, Weike. And the article was included in Journal of Chemical Research in 2013.Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate This article mentions the following:

A series of 1H-chromeno[4,3-b]pyridin-5(4H)-one derivatives, e.g., I, were synthesized via a three-component condensation of 4-aminocoumarin, aldehydes and Et benzoylacetates, under simple mild reaction conditions. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics