Author: Jessica.F

Reference of 3196-15-4, The chemical industry reduces the impact on the environment during synthesis 3196-15-4, name is Methyl 2-bromobutyrate, I believe this compound will play a more active role in future production and life.

5-Ethyl-2-pyrazin-2-yl-thiazol-4-ol: A solution of pyrazine-2-carbothioamide (1 g, 7.19 mmol) in ethanol (20 ml) was treated with methyl 2-bromobutyrate (1.56 g, 992 mul, 8.62 mmol) an pyridine (853 mg, 872 mul, 10.8 mmol) and heated to reflux for 2 hours. The reaction mixture was cooled and concentrated to dryness under reduced pressure, and the resulting solid was filtered and washed with diethyl ether to provide 5-ethyl-2-pyrazin-2-yl-thiazol-4-ol (0.740 g, 50%) which was used directly without further purification. MS (M+H)=208.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromobutyrate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hoffmann-La Roche Inc; Bhagirath, Niala; Brameld, Kenneth Albert; Kennedy-Smith, Joshua; US2013/90334; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 37466-90-3, name is Ethyl 3,4-diaminobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37466-90-3, name: Ethyl 3,4-diaminobenzoate

General procedure: Ethyl-3-amino-4-(2-substituted amino)benzoate, 3 (1 mmol) and various sodium bisulfite adducts, 4 (1.5 mmol) were dissolved in DMF (5 mL). The reaction mixture was stirred at 90 C under N2 atmosphere for 24-48 h. After completion of reaction (evident by TLC), the reaction mixture was diluted in ethyl acetate (25 mL) and washed with water (10 mL×3). The organic layer was collected, dried over Na2SO4 and evaporated under reduced pressure to afford crude products. Final compounds 5-7 were obtained in 38-90% yields after recrystallization from ethanol or column purification.

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Reference:
Article; Yoon, Yeong Keng; Ali, Mohamed Ashraf; Wei, Ang Chee; Choon, Tan Soo; Ismail, Rusli; European Journal of Medicinal Chemistry; vol. 93; (2015); p. 614 – 624;,
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Adding a certain compound to certain chemical reactions, such as: 619-45-4, name is Methyl 4-aminobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 619-45-4, Product Details of 619-45-4

To a stirred solution of compound I (1.51 g) in acetic acid Br2 (1.59 g) was added at 0 C. A large quantity of white solid was obtained. TCL result showed that no starting material remained. The solid was purified by column chromatography on silica gel (DCM:CH3OH = 20:1) to afford a white solid compound II (1.4g). The subsequent reaction followed the procedure outlined in Section 4.2.1.Total yield 0.7%, brownish yellow, 1H NMR (400 MHz, DMSO-d6): delta 7.034 (s, 3H), 7.731 (dd, J1 = 11.4 Hz, J2 = 1.60 Hz, 1H), 7.955 (d, J = 1.60 Hz, 1H), 8.647 (d, J = 8.80 Hz, 1H), 9.556 (s, 1H); 13C NMR (100 MHz, DMSO-d6): delta 179.38, 178.73, 159.26, 138.54, 128.52, 124.86, 123.93, 121.62, 116.51; HRMS (ESI) found: 345.9439, [C9H8N5S2BrO + H]+ calcd: 345.9432.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-aminobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sun, Ying; Wang, Wei; Sun, Yuanyuan; Han, Mei; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 2930 – 2936;,
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These common heterocyclic compound, 175278-29-2, name is Methyl 5-fluoro-2-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: esters-buliding-blocks

A mixture of methyl 5-fluoro-2-methylbenzoate (0.5 g, 3.0 mmol),NBS (0.18 g, 3.0 mmol), and di-benzoyl peroxide (BPO) (36 mg, 0.15 mmol) in 1,2-dichloroethane (5 mL) was heated at 80 C for 12 huntil all starting material was consumed. The reaction was cooled to room temperature, and the precipitated solid was removed by filtration and washed with ethers (10 mL). The filtrate was concentrated in vacuo and the residue was partitioned between 2 N NaHCO3 (15 mL) and ethers (15 mL). The organic layer was separated, dried over MgSO4, filtered and concentrated to give a crude product (0.65 g, 89%), which was used in the next step reaction without further purification.

The synthetic route of Methyl 5-fluoro-2-methylbenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Huang, Junli; Deng, Xiaoyan; Zhou, Siru; Wang, Na; Qin, Yujun; Meng, Liuwei; Li, Guobao; Xiong, Yuhua; Fan, Yating; Guo, Ling; Lan, Danni; Xing, Junhao; Jiang, Weizhe; Li, Qing; Bioorganic and Medicinal Chemistry; vol. 27; 4; (2019); p. 644 – 654;,
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Electric Literature of 69812-51-7,Some common heterocyclic compound, 69812-51-7, name is Methyl 4-chlorosulfonylbenzoate, molecular formula is C8H7ClO4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To an oven-dried Schlenk tube equipped with a magnetic stir bar was charged with tris(2,2′-bipyridyl)ruthenium(II) chloride (3 mol%), arenesulfonyl chloride (1.0 equiv.), heteroarene (1.0 equiv.), Na2CO3 (1.0 equiv.) and dry acetonitrile. The mixture was degassed by the freeze pump-thaw procedure, and then the Schlenk tube was irradiated under a 3W Blue LED bulb at a distance of 5 cm. After stirring at 25 C for 12 h, the solvent was removed under reduced pressure and the residue was then diluted with water. The aqueous solution was extracted (3 times) with ethyl acetate. The combined organic phases were dried over Na2SO4 and filtered. The filtrate was evaporated under reduced pressure to get the crude product, which was purified by column chromatography using hexane-ethyl acetate mixtures.

The synthetic route of 69812-51-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Natarajan, Palani; Bala, Anu; Mehta; Bhasin; Tetrahedron; vol. 72; 19; (2016); p. 2521 – 2526;,
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These common heterocyclic compound, 25415-67-2, name is Ethyl 4-methylpentanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H16O2

Under inert atmosphere, lithium diisopropylamide (4.457 g, 32 mmol) was dissolved in THF (250 ml.) and cooled to -78 C. Ethyl-4-methylvalerate (5.000 g, 35 mmol) was added dropwise and stirred at -78 C for 2 h. Benzyl bromide (7.1 16 g, 41.6 mmol) was added dropwise, stirred at – 78 C for 1 h and subsequently for 2 h at 25 C. Aq. sat. NH4CI solution was added and the or- ganic phase was extracted with MTBE, washed with water and brine, dried over MgS04, and evaporated. Column chromatography (S1O2; cyclohexane/ethyl acetate 2:1 ) yielded ethyl 2-ben- zyl-4-methyl-pentanoate (8.100 g, quant.) as colorless powder.

The synthetic route of Ethyl 4-methylpentanoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; SEET, Michael; WOLF, Antje; MUELLER, Bernd; RIEDIGER, Nadine; FEHR, Marcus; MENTZEL, Tobias; GROTE, Thomas; RUDOLF, Georg Christoph; LOHMANN, Jan Klaas; WINTER, Christian; GRAMMENOS, Wassilios; WIEBE, Christine; TERTERYAN-SEISER, Violeta; ESCRIBANO CUESTA, Ana; (200 pag.)WO2019/154663; (2019); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14062-29-4, name is Ethyl 2-(3-chlorophenyl)acetate, A new synthetic method of this compound is introduced below., Formula: C10H11ClO2

EXAMPLE 19 6-(3-Chlorobenzyl)-1-(2-trifluoromethylphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one In analogy to the preparation of Example 9, 157 mg (70% of theory) of the desired product are obtained as a colourless solid starting from 0.15 g (0.56 mmol) of 5-amino-1-(2-trifluoromethylphenyl)-1H-pyrazole-4-carboxamide (Example 27A), 0.339 g (1.67 mmol) of ethyl (3-chlorophenyl)acetate and 0.111 g (2.78 mmol) of 60% sodium hydride. m.p.: 152 C. MS (ESI pos): m/z=405 (M+H)+ 1H-NMR (300 MHz, DMSO-d6): delta=3.9 (s, 2H), 7.15-7.5 (m, 4H), 7.6-8.05 (m, 4H), 8.3 (s, 1H), 12.5 (s, 1H) ppm.

The synthetic route of 14062-29-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer HealthCare AG; US2007/161662; (2007); A1;,
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Application of 18595-14-7,Some common heterocyclic compound, 18595-14-7, name is Methyl 4-amino-3-methylbenzoate, molecular formula is C9H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Methyl 4-amino-3-methylbenzoate (6) (10.00g, 60.58mmol) was acylated with alkyl acyl chloride (90.87mmol) and triethylamine (16.79mL, 121.16mmol) in DCM at 0C. The resulting amide was reacted with fuming nitric acid in sulfuric acid (60%) at-20C. The resulting nitro-compound was reduced with hydrogen (5bar) and Raney Ni (0.79g, 13.34mmol) in methanol at 100C. The resulting amino compound was dissolved in glacial acetic acid and heated under reflux for 1h. After evaporation of the acetic acid, water was added and the pH was adjusted to 9 by addition of concentrated ammonia. This solution was extracted with ethyl acetate (3×100mL). The combined organic layers were washed with aqueous NaHCO3 solution and dried over MgSO4. After filtration, the solvent was removed under reduced pressure.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 4-amino-3-methylbenzoate, its application will become more common.

Reference:
Article; Zhu, Weibo; Bao, Xiaolu; Ren, He; Da, Yajing; Wu, Dan; Li, Fuming; Yan, Yijia; Wang, Li; Chen, Zhilong; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 161 – 178;,
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These common heterocyclic compound, 57486-69-8, name is Methyl 2-(2-bromophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: esters-buliding-blocks

Example 1 Step 1 While stirring under a nitrogen atmosphere, methyl 2-(2- bromophenyl)acetate (2g), 4,4,4,,4,,5,5,5,,5,-octamethyl-2,2,-Bi-(1 ,3,2- dioxaborolane) (2.44g), and potassium acetate (0.98g) were added to a three- neck flask containing dioxane (25 mL). The resulting mixture was degassed with nitrogen for 15 minutes followed by addition of [1 ,1 – bis(diphenylphosphino)ferrocene]dichloropalladium(ll) (0.28g). After degassing with nitrogen for an additional 15 minutes, the mixture was stirred at 80C for 8 hr. After cooling to room temperature, the solvent was removed under vacuum and the crude residue was purified by silica gel chromatography. The mass spectrum of the resulting material was consistent with methyl 2-(2-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)phenyl)acetate (2.41 g).

The synthetic route of Methyl 2-(2-bromophenyl)acetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TRANSITIONS OPTICAL, INC.; DENG, Jun; STEPP, Brian, R.; SPITLER, Eric; XIAO, Wenjing; TAMASULO, Massimiliano; WALTERS, Robert, W.; (140 pag.)WO2016/144324; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 6627-89-0, name is tert-Butyl phenyl carbonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6627-89-0, SDS of cas: 6627-89-0

Preparation of 1-(-N-Boc-aminomethyl)-4-(aminomethyl)benzene [0178] [0179] Tert-butylphenyl carbonate (2.7 mL, 14.7 mmol) was added dropwise to a solution of p-xylylenediamine (2 g, 14.7 mmol) in ethanol (20 mL) at 80 C. The reaction mixture was refluxed overnight. The solution was then cooled to room temperature and any solids were removed, which leaves a yellow solution. The solution was then concentrated to 10 mL and diluted with water (60 mL). The solution pH was adjusted to 3 with 2M HCl followed by an extraction with dichloromethane (3×75 mL). The water solution pH was then adjusted to pH 12 followed by extraction with dichloromethane (3×75 mL). The organic solutions were combined and washed with sodium bicarbonate (2×75 mL), dried with sodium sulfate, and concentrated down to a white solid. Characterization matches previously published literature (M. A. Ghanem, et al., ?Covalent modification of glassy carbon surface with organic redox probes through diamine linkers using electrochemical and solid-phase synthesis methodologies?, Journal of Materials Chemistry, (2008), 18(41), pg 4917-4927).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl phenyl carbonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; INTERNATIONAL BUSINESS MACHINES CORPORATION; Coady, Daniel Joseph; Engler, Amanda Catherine; Fukushima, Kazuki; Hedrick, James Lupton; Liu, Shaoqiong; Maune, Hareem Tariq; Nelson, Alshakim; Pitera, Jed Walter; Yang, Yi Yan; US2013/281515; (2013); A1;,
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