Author: Jessica.F

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42726-73-8, name is tert-Butyl methyl malonate, This compound has unique chemical properties. The synthetic route is as follows., name: tert-Butyl methyl malonate

Sodium hydride (3.04 g of a 50percent oil dispersion, 127 mmol) is suspended in dimethylformamide (300 ml) and the suspension is cooled to 0° C. t-Butyl methyl malonate (20.08 g, 115 mmol) is added dropwise slowly and the reaction mixture is warmed to room temperature. 1,7-Dibromoheptane (29.75 g, 115 mmol) is added dropwise and the mixture is stirred for 3 hours. The mixture is partitioned between diethyl ether (500 ml) and water (1000 ml). The organic layer is washed with water (3*500 ml), brine (1*500 ml), dried (MgSO4) and the solvent is evaporated. The product is purified by silica gel chromatography (10percent ethyl acetate/hexane) to give t-butyl methyl 7-bromoheptylmalonate as an oil.

According to the analysis of related databases, 42726-73-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ciba-Geigy Corporation; US5244889; (1993); A;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2435-36-1 as follows. Recommanded Product: Dimethyl cyclopentane-1,3-dicarboxylate

Diisopropylamine (210.0g, 201.0mmol), tetrahydrofuran (5.0L) was added to a 10L four-necked flask with mechanical stirring and thermometer. 80.0ml / 2.5M, 200.0mmol), keep -10 -60 and stir for 15min, add hexamethylphosphonic acid triamine (370.0g, 207.0mmol), control temperature -10 -60 , add cyclopentane dropwise -1,3-Dicarboxylic acid methyl ester (150.0g, 80.6mmol), after incubation and stirring for half an hour, dropwise add diiodomethane (210.0g, 80.6mmol), return to room temperature for 20min, dropwise add acetic acid (50ml) to quench After the reaction, 2.0L of 2N hydrochloric acid was added, the liquid was stirred and separated, and the organic phase was collected and concentrated to obtain the crude product, which was distilled under reduced pressure with an oil pump. Fractions around 100 C to 105 C were collected to obtain 95.0g of dicyclohexane [2.1.1] hexane- Dimethyl 1,4-dicarboxylate is a light yellow liquid with a purity of 98% and a yield of 59%.

According to the analysis of related databases, 2435-36-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suzhou Laikeshide Pharmaceutical Co., Ltd.; Zhou Miao; Yu Jurong; (5 pag.)CN110878019; (2020); A;,
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Reference of 4630-80-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4630-80-2 name is Methyl cyclopentanecarboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

n-Butyllithium (2.5 M in hexanes) (1.24 ml, 3.09 mmol) was addeddropwise to a -78 oc solution of diisopropylamine (0.440 ml, 3.09 mmol) in tetrahydrofuran(THF) (13 ml). The mixture was allowed to warm to room temperature and stirred for 15minutes. The mixture was cooled to -78 oc before methyl cyclopentanecarboxylate (0.355ml, 2.81 mmol) was added dropwise. The mixture was warmed to 0 oc and stirred for 30minutes before being cooled again to -78 C. A solution of 2-(benzyloxy)-4-(bromomethyl)-1-methoxybenzene (1.035 g, 3.37 mmol) in tetrahydrofuran (THF) (5 ml) was addeddropwise. The mixture was stirred an additional 15 minutes at -78 oc and then allowed towarm to room temperature and stirred overnight. The mixture was diluted with ethylacetate, washed with saturated ammonium chloride, washed with brine, and concentrated.The residue was purified by medium pressure reverse phase chromatography (C18 Iacetonitrile I water I 0.1% formic acid I 10% to 100% gradient). Fractions wereconcentrated. The residue was dissolved in acetonitrile and the mixture concentrated in order to azeotrope remaining water. Drying under vacuum gave methyl 1-(3-(benzyloxy)-4-methoxybenzyl)cyclopentane-1-carboxylate (716 mg, 2.02 mmol, 72 % yield) as a clear oil.LCMS (ESI) mlz: 377.3 (M+Nat.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl cyclopentanecarboxylate, and friends who are interested can also refer to it.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CATALANO, John G.; DICKSON, Hamilton D.; KAZMIERSKI, Wieslaw Mieczyslaw; LEIVERS, Martin R.; WEATHERHEAD, John Gordon; (389 pag.)WO2018/154466; (2018); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 103-25-3, name is Methyl 3-phenylpropionate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H12O2

Several other esters, whose structure and names are described in Table 3, were hydro genated under the conditions described above using preformed RuCl2(L-I). Isolated yield are given in Table 4.Table 3: Structure and names of substrates usedTable 4: Hydrogenation of esters using RuCl2(L-I) EPO Sub.: Substrate as described in Table 3.Conv.: Conversion (in %, analysed by GC after silylation) of ester to alcohol after 2h30min.Reaction conditions: Substrate (20 mmol), H2 gas (50 bars), RuCl2(L-I) 0.05 mol%,NaOMe 10 mol%, THF (14 mL) at 1000C during 2h 30min.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 103-25-3.

Reference:
Patent; FIRMENICH SA; WO2006/106484; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 87661-20-9, The chemical industry reduces the impact on the environment during synthesis 87661-20-9, name is tert-Butyl cyclopropanecarboxylate, I believe this compound will play a more active role in future production and life.

tert-Butyl 1-allylcyclopropanecarboxylate STR11 A solution of 34.1 g (0.24 mol) of tert-butyl cyclopropanecarboxylate in 25 ml of tetrahydrofuran was added dropwise at -70 C. to a mixture of 33.6 ml (0.24 mol) of diisopropylamine, 150 ml of a 1.5 molar solution of n-butyllithium in n-hexane (=0.24 mol of butyllithium) and 100 ml of tetrahydrofuran. Stirring was carried out for 3 hours at -70 C., after which a solution of 27.8 g (0.23 mol) of allyl bromide in 25 ml of tetrahydrofuran was added dropwise. Thereafter, the reaction mixture was stirred for a further 2 hours at -70 C. and then for 12 hours at 20 C. After hydrolysis with 50 ml of saturated aqueous ammonium chloride solution and after phase separation, the organic phase was worked up in a conventional manner to obtain the product. The crude product was purified by distillation. Yield: 61%, bp.: 86-88 C. at 30 mbar; colorless oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl cyclopropanecarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BASF Aktiengesellschaft; US5371268; (1994); A;,
Ester – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40876-98-0, name is Sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H11NaO5

General procedure: A mixture of malononitrile(2) (0.01 mol) and aromatic aldehyde (3) (0.01 mol) in EtOH was heated for 1 h. Next, a mixture of the sodium salt of diethyloxaloacetate (0.01 mol) (1)and hydrazine hydrate (4) in AcOH was added. The solution was heatedat 120omicronC for 15-30 min. After cooling, the precipitated solid was filtered,and recrystallized from EtOH.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 40876-98-0.

Reference:
Article; Gein; Zamaraeva; Slepukhin; Tetrahedron Letters; vol. 55; 33; (2014); p. 4525 – 4528;,
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Synthetic Route of 65868-63-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 65868-63-5, name is tert-Butyl 6-bromohexanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a suspension of t-butyl 6-bromohexanoate (500 mg, 1.99 mmol) in hexamethylphosphoramide (10 ml) was added sodium acetate (180 mg, 2.19 mmol). The reaction mixture was stirred overnight, diluted with ether, and washed with 1N aqueous hydrochloric acid (3*100 ml) and water and dried over magnesium sulfate to yield the desired diester (660 mg, 80% yield) whose structure was confirmed by NMR. The diester prepared above (1.52 g, 6.6 mmol) and ethylenediamine (539 mg, 3.82 mmol) were combined and heated to 100 C. for 2 hours. Additional ethylenediamine was added (1 equivalent) and the reaction was stirred at 100 C. for another 5 hours. The reaction mixture was then cooled to room temperature, diluted with dichloromethane (75 ml), washed with water, saturated aqueous sodium bicarbonate, 10% aqueous citric acid, and water, and dried over magnesium sulfate to yield a clear oil (560 mg). NMR analysis indicated that about 20% of the diester remained. The oil was treated with additional ethylenediamine (600 mul) at 100 C. for 2 hours and at room temperature for 48 hours. The reaction mixture was diluted with dichloromethane (100 ml), washed with saturated aqueous sodium bicarbonate, 10% aqueous citric acid, and water, dried over magnesium sulfate, and concentrated in vacuo to yield the desired t-butyl 6-hydroxyhexanoate (640 mg) in 52% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 6-bromohexanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Affymax Technologies N.V.; US5607691; (1997); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 756525-95-8,Some common heterocyclic compound, 756525-95-8, name is tert-Butyl 9-Amino-4,7-dioxanonanoate, molecular formula is C11H23NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound II-2a (4.50 g, 11.68 mmol) and Compound II-2b (3.27 g, 14.01 mmol) were dissolved in dichloromethane (250 mL), and then I- (3-dimethylaminopropyl)-at 0 C to room temperature. 3-ethylcarbodiimide hydrochloride (4.47 g, 23.35 mmol), hydroxybenzotriazole (3.15 g, 23.35 mmol) and diisopropylamine (5.96 mL, 35.03 mmol) were added. The reaction mixture was stirred at room temperature overnight. After completion of the reaction and extracted with distilled water and brine, the organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The concentrated residue was purified by silica gel column chromatography (dichloromethane: methanol = 30: 1 volume ratio) to obtain the title compound II-2c (6.55 g, 93%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 9-Amino-4,7-dioxanonanoate, its application will become more common.

Reference:
Patent; Selteurion Co., Ltd.; Park Yeong-jun; Song Hyeon-nam; Park Seong-jun; Jeong Jin-gyo; Ryu Hyeon; Cha Ji-hyeon; Choi Jun-heon; Seo Won-il; Kim Min-cheol; Park So-jin; Hyun Jae-gyeong; (61 pag.)KR2019/143246; (2019); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14273-90-6, name is Methyl 6-bromohexanoate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

General procedure: Imidazole (2.0 equiv) in THF was treated with NaH (2.0 equiv). After 3 h at rt, the respective bromoalkanoic acid ester (1.0 equiv) was added and stirring was continued for the given time. Then, the reaction solution was filtered, evaporated, and purified by CC.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Hack, Silke; Wo?rlein, Babette; Ho?fner, Georg; Pabel, Jo?rg; Wanner, Klaus T.; European Journal of Medicinal Chemistry; vol. 46; 5; (2011); p. 1483 – 1498;,
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Electric Literature of 14062-18-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14062-18-1 name is Ethyl 2-(4-methoxyphenyl)acetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To the stirred solution propargyl alpha-(4-methoxyphenyl)acetate 6a (2.04 g, 10 mmol) in 15 mL acetonitrile was added 4-acetamidobenzenesulfonyl azide (2.88 g, 12 mmol) and DBU (2.24 mL, 15 mmol) at ambient temperature under inert atmosphere. The reaction mixture was stirred for 16 h at room temperature. The reaction was quenched with saturated NH4Cl and the product was extracted with diethyl ether (30 mL x 3). The combined organic layers were washed with brine and dried over anhydrous Na2SO4. The extract was filtered and the filtrate was evaporated under vacuum. The crude product was purified using column chromatography over silica gel to afford propargyl alpha-(4-methoxyphenyl)-alpha-diazoacetate 1a as orange solid (1.934 g, 84% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-(4-methoxyphenyl)acetate, and friends who are interested can also refer to it.

Reference:
Article; Navale, Balu S.; Laha, Debasish; Bhat, Ramakrishna G.; Tetrahedron Letters; vol. 60; 29; (2019); p. 1899 – 1903;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics