Author: Jessica.F

Metabolome-Based Analysis of Herbal Cough Preparations Via Headspace Solid-Phase Microextraction GC/MS and Multivariate Data Analyses: A Prospect for Its Essential Oil Equivalency was written by Baky, Mostafa H.;Farag, Mohamed A.;Rasheed, Dalia M.. And the article was included in ACS Omega in 2020.Name: Ethyl 2-hydroxybenzoate This article mentions the following:

Liquid cough preparations containing essential oils pose a challenge for isolating and quantifying their volatile components from such a complex matrix enriched with nonvolatile constituents and excipients. This study aims to develop a strategy integrating QC anal. of seven natural cough preparations in the Egyptian market and to assess volatile variation among the preparations using multivariate data analyses. Cough preparations were subjected to headspace solid-phase microextraction (HS-SPME) for determination of their essential oil composition mediating for their actions and to assess volatile differences among them. HS-SPME is a suitable technique for sample preparation that allows for extraction and enrichment of volatiles from complex nonvolatile matrixes and their direct desorption into the gas chromatog. anal. system. A total of 88 volatile components were identified belonging to seven classes, viz. aromatics, aliphatic hydrocarbons, mono/sesquiterpene hydrocarbons, and oxygenated mono/sesquiterpenes. Oxygenated monoterpenes, viz., menthol, cineole, thymol, and (E)-anethole, were the major volatiles identified in five cough preparations (79.5-98.6%), whereas aromatics, chiefly cinnamate derivatives, constituted the second class amounting for 50.5 and 27.4% in the other two cough preparations Meaningful results regarding the products’ efficacy and safety were extrapolated from this anal. procedure, where artificial preservatives (parabens) were detected in five cough preparations This study established an efficient strategy for exploring volatile profiling and defining different markers among the different cough preparations Addnl., authenticity of listed herbal ingredients in the cough preparations was also confirmed in certain preparations, while other formulations failed to show representative volatile components. Volatile variation among preparations was assessed using multivariate data analyses in an attempt to prioritize cough preparations for usage, suggesting the preference of Bronchicum and Babetone among examined cough products. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Name: Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: Ethyl 2-hydroxybenzoate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Study of the N⁷ Regioselective Glycosylation of 6-Chloropurine and 2,6-Dichloropurine with Tin and Titanium Tetrachloride was written by Tranova, Lenka;Styskala, Jakub. And the article was included in Journal of Organic Chemistry in 2021.Reference of 4163-60-4 This article mentions the following:

6-Chloropurine and 2,6-dichloropurine were regioselectively glycosylated at position 7 to give the corresponding peracetylated N⁷-nucleosides, which can be suitable for other purine transformations. In this work, we study the distribution of N⁷/N⁹-isomers produced via the Vorbruggen method under different conditions, using an N-trimethylsilylated purine derivative and SnCl₄ or TiCl₄ as a catalyst. The main effort is devoted to reversing the disadvantageous predominant selectivity of most glycosylation reactions at the N⁹ position and thus to determining conditions that maximize the regioselectivity of glycosylation toward the desired N⁷-isomer. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Reference of 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Enolizability of S-alkyl esters of thioacetoacetic and thiomalonic acids was written by Kurgane, B.;Grinvalde, A.;Stradins, J.;Brakmane, M.;Hillers, S.. And the article was included in Zhurnal Organicheskoi Khimii in 1974.Recommanded Product: malonic acid dibutyl ester This article mentions the following:

MeCOCH2CO2R (I), MeCOCH2COSR (II), RO2CCH2CO2R (III), and RSCOCH2COSR (IV), (R = Et, CH2CH2Cl, Me2CH, PhCH2, Ph), were prepared; 6-11% I and 19-28% II were in the enol form, but III and IV existed completely in the diketo form. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Recommanded Product: malonic acid dibutyl ester).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: malonic acid dibutyl ester

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pd-Catalyzed Regioselective Alkoxycarbonylation of 1-Alkenes Using a Lewis Acid [SnCl₂ or Ti(OⁱPr)₄] and a Phosphine was written by Amezquita-Valencia, Manuel;Achonduh, George;Alper, Howard. And the article was included in Journal of Organic Chemistry in 2015.Safety of Dimethyl decanedioate This article mentions the following:

The phosphine ligand mediated palladium catalyzed alkoxycarbonylation of alkenes was investigated with the objective of attaining good linear selectivity for the ester. The effect of various parameters such as solvents, additives, palladium precursors, CO pressures, and alkenes of various structural complexities were examined The results revealed the importance of using a Lewis acid such as SnCl₂ or Ti(OⁱPr)₄ in combination with a monodentate ligand such CYTOP 292 or P(p-anisyl)₃ to enhance the regioselectivity for the linear isomers in the range of 70-96%. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Safety of Dimethyl decanedioate).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Dimethyl decanedioate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fabrication of Pb²⁺ ion selective electrode based on 1-((3-((2-hydroxynaphthalen-1-yl)methyleneamino)-2,2-dimethylpropylimino) methyl) naphthalen-2-ol as new neutral ionophore was written by Ghaedi, M.;Montazerozohori, M.;Andikaey, Z.;Shokrollahi, A.;Khodadoust, S.;Behfar, M.;Sharifi, S.. And the article was included in International Journal of Electrochemical Science in 2011.Electric Literature of C12H22O4 This article mentions the following:

The potentiometric study of complexation of 1-((3-((2-hydroxynaphthalen-1-yl)methyleneamino)-2,2-dimethylpropylimino)Me) naphthalen-2-ol (HMDMN) show strong interaction between HMDMN and Pb²⁺ ion while their formation constant was evaluated using potentiometric data. The suitability of the HMDMN for construction of new Pb²⁺ ion PVC membrane electrode and its potentiometric determination was studied. The influence of variables including pH, membrane ingredients was optimized and set as PVC:DBP:carrier:NaTPB:NaTPB/carrier mole ratio with the percent mass ratio of 28.9:57.8:8.0:5.33:0.83. At optimum values of all variables the electrode response is linear in the concentration range of 1.0 鑴?10^-6 to 0.1M with detection limit 4.0 鑴?10^-7 M with Nernstian slop of 25.79 mV/decade over the pH range of 5.0-7.2. This electrode with appropriate response time 閳?0s and suitable reproducibility (relative standard deviation), can be used for at least 2 mo without any measurable divergence in response properties. The proposed sensor reveals good selectivity toward Pb²⁺ ion with respect to many alkali, alk. earth, transition and heavy metal ions. It was applied to the determination of Pb²⁺ in water and soil samples. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Electric Literature of C12H22O4).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C12H22O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Studies directed toward the preparation of key intermediates for the synthesis of trisporic acids and cassiol was written by Colombo, Maria I.;Zinczuk, Juan;Mischne, Mirta P.;Ruveda, Edmundo A.. And the article was included in Pure and Applied Chemistry in 2001.COA of Formula: C9H16O4 This article mentions the following:

An enantioselective synthesis and resolution of the key White intermediate I for the synthesis of trisporic acids are described. Attempts to develop a synthetic route toward the antiulcerogenic compound cassiol (II) by an olefination reaction of I and an alternative sequence involving a Michael addition followed by an aldol condensation of an open substrate, are also reported. In the experiment, the researchers used many compounds, for example, Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7COA of Formula: C9H16O4).

Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C9H16O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Janus glycosides of next generation: Synthesis of 4-(3-chloropropoxy)phenyl and 4-(3-azidopropoxy)phenyl glycosides was written by Stepanova, Elena V.;Abronina, Polina I.;Zinin, Alexander I.;Chizhov, Alexander O.;Kononov, Leonid O.. And the article was included in Carbohydrate Research in 2019.Product Details of 4163-60-4 This article mentions the following:

Efficient procedures for the preparative synthesis of per-O-acyl derivatives of 4-(3-chloropropoxy)phenyl (CPP) glycosides of a series of common mono- and disaccharides (D-glucose, D-galactose, D-mannose, L-rhamnose, D-arabinofuranose, D-glucosamine, lactose) are described. The CPP glycosides obtained were transformed in almost quant. yields to the corresponding unprotected 4-(3-azidopropoxy)phenyl (APP) glycosides, which could become next-generation Janus glycosides with cleavable spacer aglycon, ready for conjugation or further transformation. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Product Details of 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phenyl bioisosteres in medicinal chemistry: discovery of novel 绾?secretase modulators as a potential treatment for Alzheimer閳ョ灚 disease was written by Ratni, H.;Baumann, K.;Bellotti, P.;Cook, X. A.;Green, L. G.;Luebbers, T.;Reutlinger, M.;Stepan, A. F.;Vifian, W.. And the article was included in RSC Medicinal Chemistry in 2021.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate This article mentions the following:

Ph rings are one of the most prevalent structural moieties in active pharmaceutical ingredients, even if they often contribute to poor physico-chem. properties. Herein, we propose the use of a bridged piperidine (BP) moiety as a Ph bioisostere, which could also be seen as a superior Ph alternative as it led to strongly improved drug like properties, in terms of solubility and lipophilicity. Addnl., this BP moiety compares favorably to the recently reported saturated Ph bioisosteres. We applied this concept to our 绾?secretase modulator (GSM) project for the potential treatment of Alzheimer閳ョ灚 disease delivering clin. candidates. In the experiment, the researchers used many compounds, for example, Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate).

Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine was written by Huang, Wei;Ma, Jing-Yi;Yuan, Mu;Xu, Long-Fei;Wei, Bang-Guo. And the article was included in Tetrahedron in 2011.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

An efficient approach to trans-4-hydroxylpyrrolidine lactams, e.g. I [R¹ = t-Bu, PhCH₂; R² = H, Me; Me₂CH, etc.; R³ = H, TBSO], starting from an amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride and antiangiogenic streptopyrrolidine. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aminopyrazine Pathway to the Moco Metabolite Dephospho Form A was written by Klewe, Anne;Kruse, Tobias;Lindel, Thomas. And the article was included in Chemistry – A European Journal in 2017.Category: esters-buliding-blocks This article mentions the following:

An efficient synthesis of the molybdopterin/molybdenum cofactor (Moco) oxidation product dephospho Form A I is described that assembles the pteridinone system starting from an iodinated aminopyrazine. The sodium salt of dephospho Form A could be purified by precipitation from methanol, which paved the way to the title compound in the 100 mg range. By HPLC, the synthetic material was compared with a sample isolated from a recombinant Moco containing protein. Anal. of dephospho Form A is the only method that allows the quantification of the Moco content of crude cell extracts and recombinant protein preparations In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Category: esters-buliding-blocks).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics