Ohanessian, Jacqueline; Caron, Michel published the artcile< A spectrophotometric study of the carbohydrate binding site of peanut lectin>, Application In Synthesis of 112-63-0, the main research area is peanut lectin carbohydrate binding; structure activity carbohydrate binding lectin.
The difference spectra spectrophotometric method (spectra recorded between 260 and 300 nm, determined at 10°) was used to determine the binding constants for specific binding of sugars (16 mono-and oligosaccharides) to peanut lectin. For C(6), an extracyclic chain is needed for lectin interaction, and orientation of the -OH group on C(6) is essential; substitution of the hydroxymethyl group decreases the strength of the association A free axial -OH on C(4) is needed for binding. A C(2) equatorial hydroxyl group is not essential for interaction, but the axial position of this group decreases the binding. Methylation of C(1) favors association; there seems to be a slight preference for the α-anomer configuration. For the glycosidic bonds, compounds with the β(1→4) linkage bind more strongly to the lectin than those with the α(1→6) linkage. Overall, these results show that the sequence C(4)-O(4), C(5), C(6)-O(6) of the galactopyranosyl ring is involved in the interactions in the carbohydrate binding site of peanut lectin as postulated previously (Lotan, R., et al, 1975), and that for di- and oligosaccharides, it appears that the configuration of C(1), the nature of the osidic bond and of the 2nd residue may influence the strength of the association
Lectins: Biology, Biochemistry, Clinical Biochemistry published new progress about Agglutinins and Lectins Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
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