Buchi, J.; Enezian, O.; Eichenberger, H.; Lieberherr, R. published the artcile< Synthesis and pharmacological action of some dialkylmalonic acid derivatives. Dialkylaminoethyl amides and esters of dialkylaminoethanols>, Quality Control of 112-63-0, the main research area is .
Heating 1 mol RR’C(CO2Et)2 in 150 mL. EtOH with 70 g. KOH in 150 mL. EtOH 2 h., evaporating the EtOH, ice-cooling, extracting with ether, HCl addition, and distillation give EtOCOCRR’CO2H (I) [R,R’, b.p., and yields (%)]: Me, Me, b0.5 93-5°, 87.5%; Et, Et, b0.4 92°, 50; Et, Pr, b0.15 118°, 72; Et, Bu, b2 133°, 96; and Pr, iso-Pr, b0.45 107°, 42.I and SOCl2 give EtOCOCRR’COCl(II): Me, Me, b1666°, 96; Et, Et, b20 93-5°, 96; Et, Pr, b15 107°, 93; Et, Bu, b20 123°, 86; and Pr, iso-Pr, b16 112°, 70. II (1 mol) in C6H6, 0.5 mol Na2CO3, and 1 mol R”R”’NCH2CH2NH2 give after heating and filtering RR’C(CO2Et)CONH(CH2)2 NR”R”’-(R, R’, R”, R”’, b.p., yield (%), and m.p. of HCl salt): Et, Et, Me, Me, b0.3 102-3°, 40, 105.5°; Me, Me, Et, Et, b0.35 108°, 80, 76-7°; Et, Et, Et, Et, b0.5 119°, 80, 104-5°; Et, Pr, Et, Et, b0.6 124°, 94, 39°; Et, Bu, Et, Et, b0.6 130°, 70; -; iso-Pr, Pr, Et, Et, b0.5 134°, 77, -. R”R”’NCH2CH2OH and II give RR’C(CO2Et)CO2(CH2)2NR”R”’: Et, Et, Me, Me, b0.2 112-14°, 49, 90.5°, Et, Et, Et, Et, b0.7 113.5°, 78-80, 105°; Et, Bu, Et, Et, b0.45 120°, 80, 93°; Et, Et, Bu, Bu, b0.4 130°, 83, -. The following Et2C(COR)2 derivatives are given (R, b.p., m.p., yield (%), and m.p. of di-HCl salt); NH(CH2)2NMe2, b0.2 159°, 32°, 48, 154°; NH(CH2)2NEt2, b0.7 174°, 47°, 88, 155°; O(CH2)2NEt2, b0.3 142°, -, 55, 162°. Pharmacol. data of these compounds are presented.
Helvetica Chimica Acta published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
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Ester – Wikipedia,
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