Yang, Shenshen; Zhang, Xinyue; Dong, Yaqian; Sun, Guijiang; Jiang, Aili; Li, Yubo published the artcile< Cleavage rules of mass spectrometry fragments and rapid identification of chemical components of Radix Paeoniae Alba using UHPLC-Q-TOF-MS>, Reference of 112-63-0, the main research area is Radix Paeoniae Alba mass spectrometry fragment; Radix Paeoniae Alba; UHPLC-Q-TOF-MS; characteristic fragment; cleavage rules; neutral loss.
Radix Paeoniae Alba (RPA) presents several pharmacol. effects, including analgesia, liver protection, and toxicity reduction RPA consists mostly of monoterpenes and their glycosides, tannins, flavonoids, and organic acids, with monoterpenes being the main active pharmaceutical ingredients. To establish an effective method for rapid classification and identification of the main monoterpenes, flavonoids, and organic acids in RPA. We used ultrahigh-performance liquid chromatog. quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) and data post-processing technol. to rapidly classify and identify the monoterpenoids, flavonoids, and organic acids in RPA. We also summarised the diagnostic product ions and neutral losses of monoterpenoids, flavonoids, and organic acids in RPA reported in the literature. We identified 24 components, namely 18 monoterpenoids, one flavonoid, and five organic acids. In this study, we analyzed the chem. active pharmaceutical ingredients and assessed the quality of RPA. In addition, we demonstrated that UHPLC-Q-TOF-MS can be used to qual. classify and identify the variety of chem. components of traditional Chinese medicines (TCMs) to a certain extent. Moreover, we confirmed that mass spectrometry can be used to identify the components of TCMs.
Phytochemical Analysis published new progress about Analgesia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
Referemce:
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