Rohrbacher, Florian; Zwicky, Andre; Bode, Jeffrey W. published the artcile< Chemical synthesis of a homoserine-mutant of the antibacterial, head-to-tail cyclized protein AS-48 by α-ketoacid-hydroxylamine (KAHA) ligation>, COA of Formula: C9H9NO4, the main research area is alphaketoacid hydroxylamine ligation antibacterial protein homoserine mutant.
An antibacterial cyclic AS-48 protein was chem. synthesized by α-ketoacid-hydroxylamine (KAHA) ligation. Initial challenges associated with the exceptionally hydrophobic segments arising from the amphiphilic nature of the protein were resolved by the development of bespoke reaction conditions for hydrophobic segments, using hexafluoroisopropanol (HFIP) as a co-solvent. The synthetic protein displays similar biol. activity and properties to those of the native protein. To support the current understanding of its antibacterial mode of action, we demonstrate the ability of AS-48 to be incorporated into synthetic multilamellar vesicles (MLVs).
Chemical Science published new progress about Antibacterial agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, COA of Formula: C9H9NO4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics