Hu, Jingyan; Ji, Xiaoming; Hao, Shuai; Zhao, Mingqin; Lai, Miao; Ren, Tianbao; Xi, Gaolei; Wang, Erbin; Wang, Juanjuan; Wu, Zhiyong published the artcile< Regioselective C-H sulfenylation of N-sulfonyl protected 7-azaindoles promoted by TBAI: a rapid synthesis of 3-thio-7-azaindoles>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is thioazaindole regioselective preparation; chloride sulfonyl protected azaindole TBAI CH sulfenylation.
This paper described the synthesis of 3-thio-7-azaindoles I [R1 = H, 2-Me, 5-Cl, 5-Br, 2-I; R2 = Ph, 4-FC6H4, 4-MeC6H4, etc.] via regioselective C-3 sulfenylation of N-sulfonyl protected 7-azaindoles with sulfonyl chlorides. In this transformation, dual roles of TBAI served as both promoter and desulfonylation reagent was demonstrated. The reaction proceeded smoothly under simple conditions to afford 3-thio-7-azaindoles I in moderate to good yields with broad substrate scopes. This protocol refrained from the use of transition-metal catalysts, strong oxidants or bases and showed its practical synthetic value in organic synthesis.
RSC Advances published new progress about Arenesulfonyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics