Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, A new synthetic method of this compound is introduced below., COA of Formula: C9H9BrO2
Dissolve NaH (140mg, 3.50mmol, 60mass%) under nitrogen protectionN,N-dimethylformamide (10 mL) was added to it under ice bathMethyl 2-(4-bromophenyl)acetate (200 mg, 0.87 mmol),After stirring for 30 min, iodomethane (0.33 mL, 5.2 mmol) was added.The reaction was allowed to warm to room temperature and stirred for 12 h.The reaction was quenched with water (20 mL), EtOAc (EtOAc)Wash with saturated brine (50 mL), dryThe title compound was obtained as a colorless oil (150 mg, 67%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Liu Xinchang; Huang Jianzhou; Zhang Yingjun; S ¡¤geerdeman; (267 pag.)CN109111451; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics