Kantzanou, Maria; Karalexi, Maria A.; Zivinaki, Anduela; Riza, Elena; Papachristou, Helen; Vasilakis, Alexis; Kontogiorgis, Christos; Linos, Athina published the artcile< Concordance of genotypic resistance interpretation algorithms in HIV-1 infected patients: An exploratory analysis in Greece>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Atazanavir Kaletra Saquinavir Tripranav antiHIV agent HIV1 infection; Antiretroviral drug; Genotypic resistance; HIV; Inter-algorithm interpretation discordances; Protease inhibitors.
Genotypic resistance-related mutations in HIV-1 disease are often difficult to interpret. Different algorithms have been developed to provide meaningful application into clin. context. We aimed to compare, for the first time in Greece, the results of genotypic resistance derived from three interpretation algorithms. The sequences of 120 HIV 1-infected patients were tested for genotypic resistance to 19 antiretroviral (ARV) drugs (n = 2280 sequences). The interpretation results of Rega, ANRS and ViroSeq algorithms were compared. Complete concordance was found for 2/19 ARV drugs, namely lamivudine and emptricitabine. Concordance was high for nucleoside reverse transcriptase inhibitors (NRTIs) and low for protease inhibitors (PIs). In inter-algorithm pairs, agreement was high between Rega and ViroSeq (kappa = 0.701), especially by ARV class, namely NRTIs (k = 0.869) and NNRTIs (k = 0.562). The only exception was noted for rilpivirine, where agreement was higher between ANRS and Rega (k = 0.410) compared to other inter-algorithm pairs (k = 0.018-0.055). By contrast, for PIs all comparisons yielded concordance equivalent to chance (k = 0.000). Our exploratory anal. provided evidence of significant inter-algorithm discordances, especially for PIs and NNRTIs highlighting the importance of matching the results of different algorithms to achieve optimized risk stratification. Ongoing research could assist clin. physicians in interpreting complex genotypic resistance patterns.
Journal of Clinical Virology published new progress about Anti-HIV agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics