Bellucci, Maria Cristina; Sacchetti, Alessandro; Volonterio, Alessandro published the artcile< Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides>, Category: esters-buliding-blocks, the main research area is orotyl aminophenylalanine preparation combinatorial multicomponent reaction regioselective cyclization; dihydroorotic acid amide preparation combinatorial multicomponent reaction regioselective cyclization; carbodiimide; combinatorial chemistry; dihydroorotic acid; domino process; multicomponent reactions.
A process featuring a sequential multicomponent reaction followed by a regioselective postcyclization strategy was implemented for the facile synthesis of N,N’-disubstituted dihydroorotic acid amides under mild conditions. We obtained, for the first time, a library of 29 derivatives, encompassing 19 Nα-substituted-N4-dihydroorotyl-4-aminophenylalanine derivatives, a key residue of gonadotropin-releasing hormone antagonist Degarelix. The corresponding products were prepared from easily accessible starting materials in good to excellent yields with broad substrate scope.
ACS Combinatorial Science published new progress about Combinatorial chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics