Reference of 55666-43-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 55666-43-8 as follows.
Preparation 12; 1,1-Dimethylethyl 3-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl]propan-oate 2-[(1-Methylethyl)oxy]-5-[3-(2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride (Example 3) (70 mg, 0.170 mmol) and caesium carbonate (167 mg, 0.511 mmol) were stirred in dry DMF (5 ml) and treated with 1,1-dimethylethyl 3-bromopropanoate (0.043 ml, 0.256 mmol) then stirred at 60 C. for 2 hours. Further quantities of 1,1-dimethylethyl 3-bromopropanoate (44 mul) were added and the reaction stirred at 60 C. for 3 hours. The reaction was left standing overnight. 1,1-Dimethylethyl 3-bromopropanoate (43 mul) was added and the reaction mixture stirred at 60 C. for 7 hours then left standing overnight. EtOAc (50 ml) was added and the reaction mixture washed with water (2¡Á50 ml), dried over anhydrous MgSO4 and evaporated to yield a clear, colourless oil (100 mg). The oil slowly solidified. Trituration with ether/hexane to yielded the title compound (70 mg) as a white solid. MS (ES) C29H34N4O4 requires 502. found 503.0 (M+H).
According to the analysis of related databases, 55666-43-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; US2010/174065; (2010); A1;,
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