Application of 106-32-1, A common heterocyclic compound, 106-32-1, name is Ethyl octanoate, molecular formula is C10H20O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dissolve 0.155037g (0.00189mol, 0.02eq) of sodium acetate and 0.100161g (0.000945mol, 0.01eq) of sodium carbonate in 5mL of water, add 100mL of ethanol, and add the colorless liquid product obtained in step (a) (containing 0.0945mol of compound 2. Based on 1.0eq), react at 40 C for 2.5 hours. During the reaction, 6.2676g (0.094878mol, 1.004eq) hydroxylamine aqueous solution was added dropwise. After the reaction was completed, it was filtered and distilled under reduced pressure to remove ethanol. After adding 100 mL of water, the temperature was lowered to 0 C, and then slowly added dropwise sulfuric acid to adjust the pH to 3.5 to precipitate a white solid, which was filtered, washed with water, and dried to obtain 14.415 g of a white solid. Based on octanoyl hydroxamic acid, the white The purity of the solid was 99.9%, and the yield was 95.7%.
The synthetic route of 106-32-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Heze Xin Eastern Countries Rihua Technology Co., Ltd.; Xue Tianhui; Chen Xiaohui; Chen Kun; Qin Lijin; (12 pag.)CN110845367; (2020); A;,
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