Authors Fernandez-Rodriguez, P; Legros, F; Maier, T; Weber, A; Mendez, M; Derdau, V; Hessler, G; Kurz, M; Villar-Garea, A; Ruf, S in WILEY-V C H VERLAG GMBH published article about CATALYZED CONJUGATE ADDITION; GRIGNARD-REAGENTS; ACIDS; ESTERS in [Fernandez-Rodriguez, Patricia; Legros, Fabien; Maier, Thomas; Weber, Angelika; Mendez, Maria; Derdau, Volker; Hessler, Gerhard; Kurz, Michael; Villar-Garea, Ana; Ruf, Sven] Sanofi Aventis Deutschland GmbH, R&D, Integrated Drug Discovery Ind Pk Hoechst, D-65926 Frankfurt, Germany in 2021.0, Cited 42.0. Category: esters-buliding-blocks. The Name is Methyl 3-phenyl-2-propenoate. Through research, I have a further understanding and discovery of 103-26-4
Photoredox chemistry has greatly stimulated the application of radical based transformations in medicinal chemistry and early drug discovery in recent years. Carboxylate groups have been identified as traceless leaving groups that can be converted into radical intermediates capable of undergoing 1,4-conjugate addition reactions to Michael acceptors. Herein, we show the successful C-terminal derivatization of small peptide substrates by using this methodology in a parallel synthesis setting. Finally, we outline a general strategy for the gamma-homologation of several drugs derived from alpha-amino acids in a late stage functionalization (LSF) approach.
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Reference:
Article; Weng, Shiue-Shien; Ke, Chih-Shueh; Chen, Fong-Kuang; Lyu, You-Fu; Lin, Guan-Ying; Tetrahedron; vol. 67; 9; (2011); p. 1640 – 1648;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics