Quality Control of Methyl 3-phenylpropionate. Huang, L; Gu, YT; Furstner, A in [Huang, Lin; Gu, Yiting; Fuerstner, Alois] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany published Iron-Catalyzed Reactions of 2-Pyridone Derivatives: 1,6-Addition and Formal Ring Opening/Cross Coupling in 2019.0, Cited 109.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3.
In the presence of simple iron salts, 2-pyridone derivatives react with Grignard reagents under mild conditions to give the corresponding 1,6-addition products; if the reaction medium is supplemented with an aprotic dipolar cosolvent after the actual addition step, the intermediates primarily formed succumb to ring opening, giving rise to non-thermodynamic Z,E-configured dienoic acid amide derivatives which are difficult to make otherwise. Control experiments as well as the isolation and crystallographic characterization of a (tricarbonyl)iron pyridone complex suggest that the active iron catalyst generated in situ exhibits high affinity to the polarized diene system embedded into the heterocyclic ring system of the substrates, which likely serves as the actual recognition element.
Quality Control of Methyl 3-phenylpropionate. About Methyl 3-phenylpropionate, If you have any questions, you can contact Huang, L; Gu, YT; Furstner, A or concate me.
Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
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