An article Synthesis of N ‘-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV) WOS:000480235700065 published article about ACIDS in [Kozlov, Maxim, V; Konduktorov, Konstantin A.; Shcherbakova, Anastasia S.; Kochetkov, Sergey N.] Russian Acad Sci, Engelhardt Inst Mol Biol, Vavilova 32, Moscow 119991, Russia in 2019.0, Cited 23.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3. Name: Methyl 3-phenylpropionate
N’-Propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs), including tubastatin A, vorinostat and belinostat, were synthesized. All prepared compounds inhibited HDAC1/2/3, but not HDAC6, except for one hydrazide analog of HDAC4/5/7 inhibitor that was completely inactive. A novel 4-substituted derivative of N’-propylbenzohydrazide with extremely high anti-HCV activity was discovered.
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Patent; SANOFI; US2011/294788; (2011); A1;,
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