I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for Aedes aegypti L. Control published in 2021.0. Quality Control of Methyl 3-phenyl-2-propenoate, Reprint Addresses de Sousa, DP (corresponding author), Univ Fed Paraiba, Post Grad Program Nat & Synthet Bioact Prod, BR-58051900 Joao Pessoa, Paraiba, Brazil.; de Sousa, DP (corresponding author), Univ Fed Paraiba, Dept Pharmaceut Sci, BR-58051970 Joao Pessoa, Paraiba, Brazil.. The CAS is 103-26-4. Through research, I have a further understanding and discovery of Methyl 3-phenyl-2-propenoate
The mosquito Aedes aegypti transmits the virus that causes dengue, yellow fever, Zika and Chikungunya viruses, and in several regions of the planet represents a vector of great clinical importance. In terms of mortality and morbidity, infections caused by Ae. aegypti are among the most serious arthropod transmitted viral diseases. The present study investigated the larvicidal potential of seventeen cinnamic acid derivatives against fourth stage Ae. aegypti larvae. The larvicide assays were performed using larval mortality rates to determine lethal concentration (LC50). Compounds containing the medium alkyl chains butyl cinnamate (7) and pentyl cinnamate (8) presented excellent larvicidal activity with LC50 values of around 0.21-0.17 mM, respectively. While among the derivatives with aryl substituents, the best LC50 result was 0.55 mM for benzyl cinnamate (13). The tested derivatives were natural compounds and in pharmacology and antiparasitic studies, many have been evaluated using biological models for environmental and toxicological safety. Molecular modeling analyses suggest that the larvicidal activity of these compounds might be due to a multi-target mechanism of action involving inhibition of a carbonic anhydrase (CA), a histone deacetylase (HDAC2), and two sodium-dependent cation-chloride co-transporters (CCC2 e CCC3).
About Methyl 3-phenyl-2-propenoate, If you have any questions, you can contact Araujo, MO; Perez-Castillo, Y; Oliveira, LHG; Nunes, FC; de Sousa, DP or concate me.. Quality Control of Methyl 3-phenyl-2-propenoate
Reference:
Article; Weng, Shiue-Shien; Ke, Chih-Shueh; Chen, Fong-Kuang; Lyu, You-Fu; Lin, Guan-Ying; Tetrahedron; vol. 67; 9; (2011); p. 1640 – 1648;,
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