Extracurricular laboratory: Synthetic route of 103-25-3

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A Rh-III-catalyzed Hiyama cross-coupling reaction has been successfully developed. Cleavage of the less polar C-C bond provides an efficient strategy to enable ketones to be as electrophilic reagents, and the corresponding substituted indoles with diverse functional groups are efficiently synthesized in good to high yields.

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Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics