Synthetic Route of 87-13-8,Some common heterocyclic compound, 87-13-8, name is Diethyl 2-(ethoxymethylene)malonate, molecular formula is C10H16O5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 1a aniline, ethanol and ethoxymethylenemalonic acid diethyl ester were successively added to a 100 mL single-necked flask, heated to 80 C in an oil bath with electromagnetic stirring and nitrogen/inert gas, and refluxed for 8 h (TLC monitoring reaction Process, developing solvent: V petroleum ether: V ethyl acetate = 6:1), after completion of the reaction, it was cooled, and ethanol was evaporated under reduced pressure to give a black oily liquid 2a.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diethyl 2-(ethoxymethylene)malonate, its application will become more common.
Reference:
Patent; Guangxi Normal University; Pan Chengxue; Wang Zengbo; Su Guifa; Liu Qingqing; Li Xiaojuan; (19 pag.)CN109705037; (2019); A;,
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