Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37746-78-4, name is (E)-Ethyl 4-bromobut-2-enoate, This compound has unique chemical properties. The synthetic route is as follows., Safety of (E)-Ethyl 4-bromobut-2-enoate
Intermediate 26 Ethyl (2E)-4-(5-bromo-2-nitrophenoxy)but-2-enoate 5-Bromo-2-nitrophenol (10 g, 45.9 mmol) and K2CO3 (8.24 g, 59.6 mmol) were suspended in NMP (81 mL) (a bright red suspension) and ethyl 4-bromocrotonate (10.26 mL, 59.63 mmol) was added dropwise at room temperature. The reaction was stirred at room temperature over night (20 h). The mixture was poured into ice/water (500 mL) and stirred for 30 min. The precipitate was collected by filtration and washed with water (2*200 mL), air dried for 10 min and then washed with heptane (200 mL). Heptane (200 mL) was added to the solid and stirred for 1 h. The solid was filtered off, washed with heptane (2*50 mL) and dried in vacuo to afford a beige solid. The title compound (15.0 g, 99%) was obtained and was used without further purification. 1H NMR (500 MHz, CDCl3) delta 1.32 (t, 3H), 4.24 (q, 2H), 4.84 (dd, 2H), 6.31 (dt, 1H), 7.04 (dt, 1H), 7.18-7.26 (m, 2H), 7.80 (d, 1H). MS m/z 298 (M-H)-.
According to the analysis of related databases, 37746-78-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; O’MAHONY, Gavin; KOSSENJANS, Michael; EDMAN, Karl; KAJANUS, Johan; HOGNER, Karl Anders; CORNWALL, Philip; TURNER, Andrew; (35 pag.)US2015/376170; (2015); A1;,
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