In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13195-64-7, name is Diisopropyl malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Diisopropyl malonate
(1) 200 mmol of diisopropyl malonate was reacted with 440 mmol of propargyl bromide plus 830 mmol of sodium hydride as a catalystInto 210mL anhydrous acetonitrile in ice water bath, stirring reaction for 8 hours, the product was washed with water, extracted with ethyl acetate, dried under reduced pressure to give the product as a brown solid, namely compound 1.
The synthetic route of 13195-64-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anhui Normal University; Hu Yimin; Fang Bo; (16 pag.)CN106946707; (2017); A;,
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