Synthetic Route of 431-47-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 431-47-0, name is Methyl 2,2,2-trifluoroacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Methyl trifluoroacetate (804 muL, 7.99 mmoles) and triethylamine (928 muL, 6.66 mmoles) were added to a suspension of glycine (500 mg, 6.66 mmoles) in methanol (2.5 mL). After the mixture was stirred vigorously for 18 h, 1 N HCl was added dropwise until the a pH of 2 was obtained. The reaction was added to ethyl acetate (30 mL) was washed with 1 N HCl (2 x 10 mL), dried over MgSO4, and concentrated in vacuo to yield the amide as a white solid (991 mg, 5.79 mmoles, 87%). LRMS: (CI+) calcd for C4H4NO3F3 (M + NH4): 189; found: 189. 1H NMR: spectrum is consistent with the predicted structure.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trifluoroacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Johns Hopkins University School of Medicine; EP1235851; (2006); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics