Synthetic Route of 6091-64-1, The chemical industry reduces the impact on the environment during synthesis 6091-64-1, name is Ethyl 2-bromobenzoate, I believe this compound will play a more active role in future production and life.
A mixture of bromide 2-bromo-benzoic acid ethyl ester (19.3 g, 84 mmol), 2,5-bis-tributylstannanyl-thieno[3,2-b]thiophene (20.2 g, 28 mmol) and anhydrous N,N-dimethylformamide (200 cm3) is degassed by nitrogen for 30 minutes. To the mixture is added bis(triphenylphosphine) palladium(II) chloride (990 mg, 1.4 mmol) and the mixture further degassed for 5 The mixture is then heated at 100 C. for 17 hours. After cooling, the mixture is poured into water (500 cm3), extracted with dichloromethane (3×300 cm3) and the combined organics dried over anhydrous magnesium sulfate, filtered and the solvent removed in vacuo. The crude product is purified by column chromatography (gradient from 40-60 petrol to dichloromethane) to give 1,1?-diethyl ester 2,2?-thieno[3,2-b]thiophene-2,5-diylbis-benzoic acid (9.44 g, 76%). MS (m/e): 436 (M+, 100%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-bromobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK PATENT GMBH; Mitchell, William; D’Lavari, Mansoor; Wang, Changsheng; Tierney, Steven; Sparrowe, David; (59 pag.)US9695190; (2017); B2;,
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