Application of 107317-58-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 107317-58-8 as follows.
To a solution of methyl 4-bromo-3-(trifluoromethyl)benzoate (10 g, 35.33 mmol) in THF (100 mL) under nitrogen was added 2 M lithium borohydride in THF (2.309 g, 106.0 mmol). The mixture was heated at reflux. The mixture was cooled to 0C and carefully quenched with 6 N HC1 (aq) (about 20 mL or less) (vigorous in the beginning 3-5 mL) up to pH 3. The mixture was diluted with water (25 mL) and extracted with EtOAc (2X). The combined organics were dried over anhydrous Na2S04and filtered. The filtrate was concentrated in vacuo to dryness to afford the crude (4-bromo-3- (trifluoromethyl)phenyl)methanol as a brown solid.
According to the analysis of related databases, 107317-58-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; SADEQUE, Abu J.M.; BUZARD, Daniel J.; (82 pag.)WO2020/51378; (2020); A1;,
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