4341-76-8, name is Ethyl 2-butynoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 4341-76-8
General procedure: In a 1 dram vial, methyl non-2-ynoate (88 mg, 1.0 equiv), 4-picoline (2.55 muL, 0.05equiv.), half the amount of bis(pinacolato)diboron (198 mg total, 1.5 equiv), and 1 mL of 1.3mg/mL CuSO4 stock solution (0.01 equiv.) are mixed and stirred vigorously at 50 C. The remaining half of bis(pinacolato)diboron is added over a period of 10 minutes. After 3 hours, 1mL of hexanes is added to quench the reaction. The aqueous layer is extracted 3x with hexanes. The hexanes layer is washed 5x with water, dried over sodium sulfate, filtered, and concentrated in vacuo. Column chromatography is used to purify the product.
The synthetic route of 4341-76-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Peck, Cheryl L.; Calderone, Joseph A.; Santos, Webster L.; Synthesis; vol. 47; 15; (2015); p. 2242 – 2248;,
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