Synthetic Route of 5445-17-0, The chemical industry reduces the impact on the environment during synthesis 5445-17-0, name is Methyl 2-bromopropanoate, I believe this compound will play a more active role in future production and life.
General procedure: In a round-bottomed flask, activated iron dust (168 mg,3 mmol) was added to a solution of alpha-bromo carbonyl compounds (1.0 mmol) and diaryl disulfides (0.5 mmol) in DMF (3.0mL). The reaction mixture was stirred at 90C under N2 atmosphere for 15 h. Then ethyl acetate (20 mL) was added, stirred, and filtered. To filter liquor, the water (15 mL) was added and the mixture was extracted with ethyl acetate (15 mL × 3). The combined organic phase was washed with water (20 mL × 2), dried over anhydrous Na2SO4 , and concentrated under vacuum. The crude product was purified by column chromatography on silica gel (petroleum ether /ethyl acetate = 30:1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromopropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; He, Yun-Hua; Li, Ning-Bo; Chen, Jin-Yang; Qiu, Ren-Hua; Wang, Xie; Xu, Xin-Hua; Synthetic Communications; vol. 45; 15; (2015); p. 1817 – 1822;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics