Application of 2967-66-0, The chemical industry reduces the impact on the environment during synthesis 2967-66-0, name is Methyl 4-(trifluoromethyl)benzoate, I believe this compound will play a more active role in future production and life.
General procedure: In an argon filled glove-box, a ca. 80 ml. Premex stainless steel autocalve fitted with a PTFE in- ner chamber and a PTFE coated magnetic stirring bar was charged with Ru(L)CO (I) (6×10-3 mmol, 4.7 mg), the specified ester (0.6 mmol), degassed, anhydrous 1 ,4-dioxane (6.0 ml.) and degassed anhydrous methanol (0.05 ml_). Hexamethylbenzene (0.15 mmol, as internal stand- ard) was added and the mixture was stirred vigorously at room temperature until full dissolution. A sample (0.1 ml.) was then taken for to-analysis (GC and NMR). After closing the reaction ves- sel was removed from the glove-box. The argon atmosphere in the autoclave was replaced with H2 by twice pressurization to 30 bar, and pressure release at room temperature. The autoclave was then pressurized with H2 gas (60 bar). The solution was heated at 130 C (heating mantel temperature) with stirring for 17 hrs. After cooling to 0 C, the system was vented carefully and purged for 1 minute with argon. A sample of the crude mixture (0.1 ml.) was transferred to a vial and was analyzed as-is by GC on an Agilent Technologies 6890N gas chromatography system equipped with a FID detector and an Agilent Technologies DB-1 capillary column (30 m x 0.250 mm / 1.0 pm). Another sample (0.1 ml.) was diluted with CDCI3 (0.6 ml.) in an NMR tube and analyzed by 1H-NMR. Conversion was determined by comparison to the samples at to (with hex- amethylbenzene as internal standard). NMR yield was determined by the ratio of product to starting material in the crude sample after reaction.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-(trifluoromethyl)benzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BASF SE; SCHAUB, Thomas; ANABY, Aviel; SCHELWIES, Mathias; PACIELLO, Rocco; SCHWABEN, Jonas; HASHMI, A. Stephen K.; (44 pag.)WO2019/138000; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics