Electric Literature of 10047-10-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10047-10-6 as follows.
Glacial AcOH (4.2 mL, 73.4 mmol) was added to a magnetically stirred solution of 2,5-dimethoxytetrahydrofuran (11.5 mL, 88.8 mmol) in H2O (200 mL) maintained under N2 and the ensuing mixture was heated at reflux. After 3 h, the mixture was cooled to r.t. and CH2Cl2 (200 mL), NaOAc (18.2g, 221 mmol) and DL-norvaline methyl ester hydrochloride (S8) (12.22 g, 72.9 mmol, as a ~40 mL solution in H2O) were added; the flask was wrapped in foil to exclude light. After 16 h, the pH of the aqueous phase was adjusted to ~9 with Na2CO3 (saturated aqueous solution). The phases were separated and the aqueous phase was further extracted with CH2Cl2 (3x 50 mL). The combined organic extracts were dried (MgSO4), filtered and concentrated under reduced pressure to a volume of ~25 mL. The ensuing solution was passed through plug of silica gel (7 cm width x 3 cm depth; 20% EtOAc/hexanes elution) to provide pyrrole S9 (12.4 g, 68.6 mmol, 94% yield) as a colourless oil.2
According to the analysis of related databases, 10047-10-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Olivier, Wesley J.; Gardiner, Michael G.; Bissember, Alex C.; Smith, Jason A.; Tetrahedron; vol. 74; 38; (2018); p. 5436 – 5441;,
Ester – Wikipedia,
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