Application of 79669-50-4, The chemical industry reduces the impact on the environment during synthesis 79669-50-4, name is methyl 5-bromo-2-methyl-benzoate, I believe this compound will play a more active role in future production and life.
To a mixture of 13 (1.50 g, 6.60 mmol) and 1, 4-dioxane (25 mL), was added Bis(pinacolato)diboron (1.78 g, 6.90 mmol), Pd(dppf)Cl2 (483.00 mg, 0.66 mmol) and KOAc (1.60 g, 13.20 mmol). The mixture were stirred at 90 oC for 5 h. After cooling to room temperature the mixture were filtered and the solvent was evaporated under reduced pressure. The residue was purification by column chromatography on silica gel to give the yellow solid. Yield 94%. m.p. 80~81 oC. 1H NMR (300 MHz, CDCl3) delta (ppm): 8.36 (s, 1H, ArH), 7.85 (dd, J = 7.60, 1.20 Hz, 1H, ArH), 7.30 (s, 1H, ArH), 3.92 (s, 3H, OCH3), 2.65 (s, 3H, CH3), 1.38 (s, 12H, CH3).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, methyl 5-bromo-2-methyl-benzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ji, Dezhong; Zhang, Lingzhi; Zhu, Qihua; Bai, Ying; Wu, Yaoyao; Xu, Yungen; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 334 – 341;,
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