Synthetic Route of 4891-38-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4891-38-7, name is Methyl Phenylpropiolate, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: A representative procedure of skeleton 1 is as follows: CuI (190 mg, 1.0 mmol), Et3N (200 mg, 2.0 mmol) and different alkynes 6a-h (1.0 mmol) were added to a solution of compound 5a (110 mg, 0.4 mmol) in anhydrous DMF (4 mL) at rt. The reaction mixture was stirred at 80 C for 2 h, then cooled to rt. Saturated NaHCO3(aq) (5 mL) was added to the reaction mixture and the solvent was evaporated under reduced pressure. The residue was extracted with EtOAc (3 x 30 mL). The combined organic layers were washed with brine,dried, filtered and evaporated under reduced pressure to afford crude product. Purification on silica gel (hexanes/EtOAc = 2/1-1/2) afforded compounds 1a-h.
The chemical industry reduces the impact on the environment during synthesis Methyl Phenylpropiolate. I believe this compound will play a more active role in future production and life.
Reference:
Article; Chang, Meng-Yang; Tai, Hang-Yi; Synthetic Communications; vol. 43; 24; (2013); p. 3363 – 3372;,
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