Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3044-06-2, name is Diethyl 2-(1-ethoxyethylidene)malonate, A new synthetic method of this compound is introduced below., name: Diethyl 2-(1-ethoxyethylidene)malonate
4-isopropoxy-3-cyanobenzidine hydrochloride (1 g, 0.0042 mol), M-230 (1.06 g, 0.0046 mol),A fresh methanol solution of sodium ethoxide (3 g of sodium hydride (20%) was added to 100 ml of ethanol at a low temperature) (20 ml), and refluxed for 2 hours. After the reaction was completed by TLC, the reaction mixture was cooled to room temperature, and 6N was gradually added to the reaction mixture. ofThe pH of the mixture was adjusted to 1 with HCl, stirred for 30 min, filtered, filtered, washed with water and dried. The obtained crude product was recrystallized from ethanol to give a white solid, 0.44 g.Yield: 31.1%
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shenyang Hainuowei Pharmaceutical Technology Co., Ltd.; Wang Shaojie; Mao Qing; Zhang Bing; (30 pag.)CN110156698; (2019); A;,
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