Research on new synthetic routes about tert-Butyl 3-bromopropanoate

Reference of 55666-43-8, These common heterocyclic compound, 55666-43-8, name is tert-Butyl 3-bromopropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference of 55666-43-8, These common heterocyclic compound, 55666-43-8, name is tert-Butyl 3-bromopropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

0.3 g of the molecule 5 was dissolved in 5 ml of dry DMF,Cold to 0 degrees,Adding 40 mg of sodium hydride,Reaction for 15 minutes,Adding one equivalent of t-butyl 3-bromopropionate,Reaction for half an hour, warming up to 50 degrees reaction 24 hours,Rotate DMF, add 20 ml of water,Ethyl acetate extraction, combined organic phase,Saturated with salt water, anhydrous sodium sulfate drying, pumping, spin drying, and then silica gel column to get the molecular 6, the yield of 45%

Statistics shows that tert-Butyl 3-bromopropanoate is playing an increasingly important role. we look forward to future research findings about 55666-43-8.

Reference:
Patent; University of Science and Technology of China; Zhang Guoqing; Chen Biao; Xu Cheng; Wang Hao; Du Jiajun; Bi Guoqiang; Luo Yi; (111 pag.)CN107118586; (2017); A;,
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