4897-84-1, A common compound: 4897-84-1, name is Methyl 4-bromobutanoate, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
To a solution of Lambda/-[4-(7-Hydroxy-6-methoxy-quinolin-4-yloxy)-phenyl]-benzamide (170mg, 0.44mmol) in anhydrous DMF (15ml) was added potassium carbonate (121 mg, O.deltadeltammol, 2eq) and methyl-4-bromobutyrate (83mul, 0.66mmol, 1.5eq). The reaction was stirred at room temperature for 48 hours. The DMF was removed under reduced pressure and ethyl acetate was added to the crude residue, washing with water. The ethyl acetate layer was dried over magnesium sulphate and evaporated under reduced pressure. The crude product was isolated as a yellow oil (220mg, >100percent) and was taken forward without further purification. LCMS (254 nm), m/z 487.2 [M+H]+. 1H NMR (300 MHz, CDCI3), delta: 8.32 (1 H, d, J=5.3Hz), 7.90- 7.84 (1 H, m), 7.75 (2H, dd, J=8.2, 1.4Hz), 7.65-7.58 (2H, m), 7.46-7.32 (3H, m), 7.11 (1 H, s), 7.08-7.02 (2H, m), 6.33 (1 H, d, J=5.3Hz), 4.08 (2H, t, J=6.2Hz), 3.87 (3H, s), 3.55 (3H, s), 2.45 (2H1 1, J=7.3Hz), 2.17-2.06 (2H, m).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-bromobutanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CHROMA THERAPEUTICS LTD; WO2006/117570; (2006); A1;,
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