Reference of 6091-64-1, These common heterocyclic compound, 6091-64-1, name is Ethyl 2-bromobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Ethyl 2-bromobenzoate (1g, 4.37mmol) prepared from Step 1 wasdissolved in toluene (20 mL) and ethanol (4mL) mixed solution, and then theretowere added 4-fluorophenyl boronic acid (672mg, 4.80mmol), potassium carbonate(1.21g, 8.73mmol) and tetrakis (triphenylphosphine) palladium (504mg,0.44mmol). The reaction was stirred at 100 deg. C 6 hours, cooled to roomtemperature and filtered through Celite. The reaction was concentrated underreduced pressure to remove the solvent. Then washed with water and extracted ethyl acetate. Theorganic layer was dried over anhydrous magnesium sulfate, filtered andconcentrated. The resulting residue was purified by column chromatography toproduce the title compound (948mg, 89%).
Statistics shows that Ethyl 2-bromobenzoate is playing an increasingly important role. we look forward to future research findings about 6091-64-1.
Reference:
Patent; East Asia ST Corporation; Jin, Shunhui; Ren, Yuanbin; Cao, Zonghuan; Cui, Shangao; Pu, Zhengxiang; Jin, Miyan; Cui, Chenghe; Lee, Mingjing; Zhao, Kangxun; (182 pag.)CN105555761; (2016); A;,
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