Reference of 6836-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6836-21-1, name is Ethyl 2-(7-methoxynaphthalen-1-yl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Ethyl 2-(2-methoxy naphthalen-8-yl)acetate (2.0 g, 8.1 mmol)was dissolved in ethanol (40 mL, 20 vol) and cooled to -78 to-74 C, ammonia gas was purged to reaction mass for 30 minat -78 to -74 C, after purging slowly allowed to 25-30 C and stir for 2 h. The reaction mass stored for 48 h at 25-30 C,then mass was concentrated completely under reduced pressureto obtained crude material which was triturated in toluene (20mL, 10 vol) for 1 h and filtered the solid, then washed withtoluene (10 mL, 5 vol) suck dried the compound to get paleyellow coloured solid (1. 5 g, 87.6 % yield).IR (KBr, numax, cm-1): 3395, 3203, 2939, 2831, 1643, 1401,1259, 1203, 1024, 827 ; 1H NMR (400 MHz, DMSO-d6): delta7.84 (d, J = 8.8 Hz, 1H), 7.73 (d, J = 7.0 Hz, 1H), 7.61 (brs,1H), 7.4 (t, J = 6.8 Hz, 2H), 7.28 (t, J = 7.2 Hz, 1H), 7.19 (dd,J1 = 2.0 Hz, J2 = 9.2 Hz, 1H), 7.02 (brs, 1H), 3.87 (s, 3H), 3.81(s, 2H); 13C NMR (100Hz, DMSO-d6): delta 172.14, 157.22,133.14, 131.67, 129.87, 128.65, 128.20, 126.62, 123.01,117.58, 103.37, 55.11; EI-MS m/z (%): 216 (M + 1, 84), 199(27), 171 (100).
The synthetic route of Ethyl 2-(7-methoxynaphthalen-1-yl)acetate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gurunadham; Raju, R. Madhusudhan; Venkateswarlu; Asian Journal of Chemistry; vol. 28; 6; (2016); p. 1367 – 1370;,
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