Application of 1187318-53-1,Some common heterocyclic compound, 1187318-53-1, name is 3-Bromo-5-fluoro-2-methyl-benzoic acid methyl ester, molecular formula is C9H8BrFO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0517] To a solution of methyl 3-bromo-5-fluoro-2-methylbenzoate (2.0 g, 8.13 mmol) in CCl4 (20 mL) at rt was added NBS (2.2 g, 12.19 mmol) and AIBN ( 533 mg, 3.25 mmol). The suspension was stirred at 90C for 16 hrs, cooled to rt, and filtered. The filtrate was concentrated under vacuum to afford the crude product, which was purified on silica gel with petroleum ether / EA = 50/1 to afford methyl 3-bromo-2-(bromomethyl)-5- fluorobenzoate (2.5 g yield : 96% ) as a yellow oil.
The synthetic route of 1187318-53-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOTHERYX, INC.; CHAN, Kyle, W.H.; FUNG, Leah; SULLIVAN, Robert; ERDMAN, Paul, E.; MERCURIO, Frank; (225 pag.)WO2017/201069; (2017); A1;,
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