Reference of 57486-69-8, These common heterocyclic compound, 57486-69-8, name is Methyl 2-(2-bromophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl 2-bromophenylacetate (3.8 g) in tetrahydrofuran (50 mL) cool to -78 C,1.6 mol / L lithium hexamethyldisilazide(13.3 mL, 21 mmol) was added dropwise and the mixture was stirred for 1 hour. Subsequently, methyl iodide was added, the temperature was raised to room temperature, and the mixture was stirred for 3 hours. Saturated ammonium chloride aqueous solution was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate, After filtration, the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography,The target compound was obtained (3.0 g, 75%).
Statistics shows that Methyl 2-(2-bromophenyl)acetate is playing an increasingly important role. we look forward to future research findings about 57486-69-8.
Reference:
Patent; SUMITOMO DAINIPPON PHARMA COMPANY LIMITED; SUMIYOSHI, TAKAAKI; TAKAHASHI, YOKO; URUNO, YOSHIHARU; TAKAI, KENTARO; SUWA, ATSUSHI; MURATA, YASUKO; (58 pag.)JP2015/83543; (2015); A;,
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