5-Ethyl-5-(2-thienyl)barbituric acid was written by Blicke, F. F.;Zienty, M. F.. And the article was included in Journal of the American Chemical Society in 1941.Safety of Methyl 2-thienylacetate This article mentions the following:
5-Ethyl-5-(2-thienyl)barbituric acid (I), m. 179-80°, was prepared by the following series of reactions: 2-thienyl-magnesium bromide and solid CO2 give 92% of 2-thiophenecarboxylic acid; SOCl2 gives 85% of 2-thenoyl chloride; CH2N2 gives 2-thienyl diazomethyl ketones, m. 67-8°; Ag2O in absolute alc. gives 68% of Et 2-thiopheneacetate, b26 124-9°; Me ester, b23 115-18°; the free acid m. 75-6° (cf. Ger. pat. 650,706, C. A. 32, 595.5); 2-thienylmethyl chloride with NaCN in 50% EtOH gives 60% of 2-thienylmethyl cyanide, b22 115-20°; hydrolysis of 5 g. gives 2 g. of 2-thiopheneacetic acid, m. 75-6°; the Et ester and (CO2Et)2 with EtONa, followed by pyrolysis of the Et α-ethoxalyl-2-thiopheneacetate at 155-60° and 20 mm., give 38% of di-Et 2-thienylmalonate, pale yellow, b5 145-8°; the Na derivative and EtBr give 64% of the Et derivative, b5 148-50°; refluxing with urea and Mg in absolute MeOH for 12 hrs. gives 58% of I. Preliminary results indicate that I is as active as phenobarbital. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Safety of Methyl 2-thienylacetate).
Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of Methyl 2-thienylacetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics