Absolute configuration of in situ crystallized (+)-绾?decalactone was written by Patzer, Michael;Noethling, Nils;Goddard, Richard;Lehmann, Christian W.. And the article was included in Chemistry (Basel, Switzerland) in 2021.Application In Synthesis of 5-Hexyldihydrofuran-2(3H)-one This article mentions the following:
Knowledge about the absolute configuration of small bioactive organic mols. is essential in pharmaceutical research because enantiomers can exhibit considerably different effects on living organisms. X-ray crystallog. enables chemists to determine the absolute configuration of an enantiopure compound due to anomalous dispersion. Here, we present the determination of the absolute configuration of the flavoring agent (+)-绾?decalactone, which is liquid under ambient conditions. Single crystals were grown from the liquid in a glass capillary by in situ cryo-crystallization Diffraction data collection was performed using Cu-K浼?radiation. The absolute configuration was confirmed. The mol. consists of a linear aliphatic non-polar backbone and a polar lactone head. In the solid state, layers of polar and non-polar sections of the mol. alternating along the c-axis of the unit cell are observed In favorable cases, this method of absolute configuration determination of pure liquid (bioactive) agents or liquid products from asym. catalysis is a convenient alternative to conventional methods of absolute structure determination, such as ORD, vibrational CD, UV-visible spectroscopy, use of chiral shift reagents in proton NMR and Coulomb explosion imaging. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Application In Synthesis of 5-Hexyldihydrofuran-2(3H)-one).
5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of 5-Hexyldihydrofuran-2(3H)-one
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics