Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor was written by Melancon, Bruce J.;Gogliotti, Rocco D.;Tarr, James C.;Saleh, Sam A.;Chauder, Brian A.;Lebois, Evan P.;Cho, Hyekyung P.;Utley, Thomas J.;Sheffler, Douglas J.;Bridges, Thomas M.;Morrison, Ryan D.;Daniels, J. Scott;Niswender, Colleen M.;Conn, P. Jeffrey;Lindsley, Craig W.;Wood, Michael R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate This article mentions the following:
This Letter describes the continued optimization of the MLPCN probe mol. ML071 (I). After introducing numerous cyclic constraints and novel substitutions throughout the parent structure, we produced a number of more highly potent agonists of the M1 mACh receptor, e.g., II. While many novel agonists demonstrated a promising ability to increase soluble APP浼?release, further characterization indicated they may be functioning as bitopic agonists. These results and the implications of a bitopic mode of action are presented. In the experiment, the researchers used many compounds, for example, Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate).
Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics